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    NANOPARTICLE VACCINES WITH NOVEL STRUCTURAL COMPONENTS
    2.
    发明申请
    NANOPARTICLE VACCINES WITH NOVEL STRUCTURAL COMPONENTS 有权

    公开(公告)号：US20220031835A1

    公开(公告)日：2022-02-03

    申请号：US17386289

    申请日：2021-07-27

    申请人： The Scripps Research Institute

    发明人： Linling He ,  Jiang Zhu

    IPC分类号： A61K39/21 ,  C12N15/86 ,  A61P31/18

    摘要： The present invention provides novel nanoparticle presented vaccine compositions that are stabilized with a locking domain. Various immunogens can be employed in the preparation of the vaccine compositions, including viral immunogens such as HIV-1 and Ebola viral immunogens, and non-viral immunogens such as immunogens derived from bacteria, parasites and mammalian species. The invention also provides methods of using such vaccine compositions in various therapeutic applications, e.g., for preventing or treating viral infections.

    Scaffolded HIV-1 Env GP140 trimer immunogen
    5.
    发明授权
    Scaffolded HIV-1 Env GP140 trimer immunogen 有权

    公开(公告)号：US11452771B2

    公开(公告)日：2022-09-27

    申请号：US17021821

    申请日：2020-09-15

    申请人： The Scripps Research Institute

    发明人： Jiang Zhu ,  Linling He

    IPC分类号： A61K39/12 ,  A61K47/64 ,  A61P31/18 ,  A61K39/21 ,  A61K9/51 ,  C07K14/16 ,  A61K38/16 ,  C07K14/005 ,  A61K47/69 ,  A61K39/00

    摘要： The present invention provides novel scaffolded HIV-1 vaccine immunogens. Some of the scaffolded immunogens contain a soluble gp140 trimer linked to the N-terminus of the nanoparticle subunit and a T-helper epitope that is fused via a short peptide spacer to the C-terminus of the nanoparticle subunit. Some other immunogens of the invention contain a soluble gp140 trimer protein that is linked to a stable nanoparticle via a short peptide spacer that is a T-helper epitope. Some of the scaffolded immunogens contain a gp140 trimer immunogen presented on a nanoparticle platform formed with I3-01 protein, E2p, or variants of protein 1VLW. Also provided in the invention are nucleic acids that encode the various vaccine immunogens described herein, and expression vectors and host cells harboring the nucleic acids. The invention further provides methods of using the scaffolded HIV-1 vaccine immunogens for preventing or treating HIV infections.

    SCAFFOLDED HIV-1 VACCINE IMMUNOGENS
    8.
    发明公开
    SCAFFOLDED HIV-1 VACCINE IMMUNOGENS 审中-公开

    公开(公告)号：US20230190910A1

    公开(公告)日：2023-06-22

    申请号：US17896799

    申请日：2022-08-26

    申请人： THE SCRIPPS RESEARCH INSTITUTE

    发明人： Jiang Zhu ,  Linling He

    IPC分类号： A61K39/12 ,  A61K47/64 ,  A61P31/18 ,  A61K39/21 ,  A61K9/51 ,  C07K14/16 ,  A61K38/16 ,  C07K14/005

    CPC分类号： A61K39/12 ,  A61K47/646 ,  A61P31/18 ,  A61K39/21 ,  A61K9/51 ,  C07K14/162 ,  A61K38/162 ,  C07K14/005 ,  A61K47/69

    摘要： The present invention provides novel scaffolded HIV-1 vaccine immunogens. Some of the scaffolded immunogens contain a soluble gp140 trimer linked to the N-terminus of the nanoparticle subunit and a T-helper epitope that is fused via a short peptide spacer to the C-terminus of the nanoparticle subunit. Some other immunogens of the invention contain a soluble gp140 trimer protein that is linked to a stable nanoparticle via a short peptide spacer that is a T-helper epitope. Some of the scaffolded immunogens contain a gp140 trimer immunogen presented on a nanoparticle platform formed with I3-01 protein, E2p, or variants of protein 1VLW. Also provided in the invention are nucleic acids that encode the various vaccine immunogens described herein, and expression vectors and host cells harboring the nucleic acids. The invention further provides methods of using the scaffolded HIV-1 vaccine immunogens for preventing or treating HIV infections.

    Scaffolded HIV-1 vaccine immunogens
    10.
    发明授权
    Scaffolded HIV-1 vaccine immunogens 有权

    公开(公告)号：US10780178B2

    公开(公告)日：2020-09-22

    申请号：US16177165

    申请日：2018-10-31

    申请人： The Scripps Research Institute

    发明人： Jiang Zhu ,  Linling He

    IPC分类号： A61K39/21 ,  A61K47/64 ,  A61P31/18 ,  A61K9/51 ,  C07K14/16 ,  A61K47/69 ,  A61K38/16 ,  C07K14/005 ,  A61K39/12 ,  A61K39/00

    摘要： The present invention provides novel scaffolded HIV-1 vaccine immunogens. Some of the scaffolded immunogens contain a soluble gp140 trimer linked to the N-terminus of the nanoparticle subunit and a T-helper epitope that is fused via a short peptide spacer to the C-terminus of the nanoparticle subunit. Some other immunogens of the invention contain a soluble gp140 trimer protein that is linked to a stable nanoparticle via a short peptide spacer that is a T-helper epitope. Some of the scaffolded immunogens contain a gp140 trimer immunogen presented on a nanoparticle platform formed with I3-01 protein, E2p, or variants of protein 1VLW. Also provided in the invention are nucleic acids that encode the various vaccine immunogens described herein, and expression vectors and host cells harboring the nucleic acids. The invention further provides methods of using the scaffolded HIV-1 vaccine immunogens for preventing or treating HIV infections.