公开(公告)号：US20180078575A1

公开(公告)日：2018-03-22

申请号：US15562149

申请日：2016-03-25

申请人： THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK

发明人： George B. Stefano ,  Richard M. Kream ,  Kirk J. Mantione

IPC分类号： A61K31/718 ,  A61K9/20 ,  A61K31/385 ,  A61K31/355 ,  A61K36/81

CPC分类号： A61K31/718 ,  A61K9/0053 ,  A61K9/08 ,  A61K9/20 ,  A61K31/355 ,  A61K31/385 ,  A61K36/81 ,  A61P25/28

摘要： This document provides methods and materials for reducing amyloid beta levels within a mammal (e.g. a mammal having Alzheimer's disease). For example, this document provides methods for using compositions containing a potato polysaccharide preparation to reduce one or more symptoms of Alzheimer's disease. In some cases, a composition containing a potato polysaccharide preparation provided herein can be used to increase binding, sequestration, and/or degradation of CNS-derived amyloid beta polypeptides, thereby inhibiting the formation of neurofibrillary plaques.

公开(公告)号：US11253538B2

公开(公告)日：2022-02-22

申请号：US16866366

申请日：2020-05-04

申请人： THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK

发明人： George B. Stefano ,  Richard M. Kream ,  Kirk J. Mantione

IPC分类号： A61K31/718 ,  A61K36/81 ,  A61K9/00 ,  A61K9/08 ,  A61P25/28 ,  A61K9/20 ,  A61K31/355 ,  A61K31/385

摘要： This document provides methods and materials for reducing amyloid beta levels within a mammal (e.g. a mammal having Alzheimer's disease). For example, this document provides methods for using compositions containing a potato polysaccharide preparation to reduce one or more symptoms of Alzheimer's disease. In some cases, a composition containing a potato polysaccharide preparation provided herein can be used to increase binding, sequestration, and/or degradation of CNS-derived amyloid beta polypeptides, thereby inhibiting the formation of neurofibrillary plaques.

公开(公告)号：US20180078599A1

公开(公告)日：2018-03-22

申请号：US15562136

申请日：2016-03-25

申请人： THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK

发明人： George B. Stefano ,  Richard M. Kream ,  Kirk J. Mantione

IPC分类号： A61K36/81 ,  A61K31/715 ,  A61K45/06 ,  A61K9/20 ,  A61K31/385 ,  A61K31/355

CPC分类号： A61K36/81 ,  A61K9/20 ,  A61K31/355 ,  A61K31/385 ,  A61K31/715 ,  A61K45/06 ,  C08B37/00

摘要： This document provides methods and materials for treating cancer. For example, this document provides methods for using compositions containing a potato polysaccharide preparation to reduce the number of cancer cells in a mammal. In some cases, a composition containing a potato polysaccharide preparation provided herein can be used to reduce the number of cancer cells in a mammal, wherein the cancer cells express a KRAS polypeptide.

公开(公告)号：US09474749B2

公开(公告)日：2016-10-25

申请号：US14460809

申请日：2014-08-15

申请人： The Research Foundation for the State University of New York

发明人： George B. Stefano ,  Patrick Cadet ,  Kirk J. Mantione ,  Wei Zhu

IPC分类号： A61K31/44 ,  A61K31/485 ,  A23L1/30 ,  A61K31/198 ,  A61K31/7052 ,  A61K33/04 ,  A61K33/06 ,  A61K31/194 ,  A61K31/472 ,  A61K45/06

CPC分类号： A61K31/485 ,  A23L33/10 ,  A23V2002/00 ,  A61K31/194 ,  A61K31/198 ,  A61K31/472 ,  A61K31/7052 ,  A61K33/04 ,  A61K33/06 ,  A61K45/06 ,  A61K2300/00 ,  A23V2200/322 ,  A23V2250/30 ,  A23V2250/0606 ,  A23V2250/1626

摘要： Methods and materials related to the use of morphine, morphine precursors (e.g., reticuline), and inhibitors of morphine synthesis or activity to treat diseases, to reduce inflammation, or to restore normal function are provided.

公开(公告)号：US20200268787A1

公开(公告)日：2020-08-27

申请号：US16866366

申请日：2020-05-04

申请人： THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK

发明人： George B. Stefano ,  Richard M. Kream ,  Kirk J. Mantione

IPC分类号： A61K31/718 ,  A61K36/81 ,  A61K9/00 ,  A61K9/08 ,  A61P25/28 ,  A61K9/20 ,  A61K31/355 ,  A61K31/385

摘要： This document provides methods and materials for reducing amyloid beta levels within a mammal (e.g. a mammal having Alzheimer's disease). For example, this document provides methods for using compositions containing a potato polysaccharide preparation to reduce one or more symptoms of Alzheimer's disease. In some cases, a composition containing a potato polysaccharide preparation provided herein can be used to increase binding, sequestration, and/or degradation of CNS-derived amyloid beta polypeptides, thereby inhibiting the formation of neurofibrillary plaques.

公开(公告)号：US08865696B2

公开(公告)日：2014-10-21

申请号：US13924211

申请日：2013-06-21

申请人： The Research Foundation for the State University of New York

发明人： George B. Stefano ,  Patrick Cadet ,  Kirk J. Mantione ,  Wei Zhu

IPC分类号： A61K31/555 ,  A61K31/44

CPC分类号： A61K31/485 ,  A23L33/10 ,  A23V2002/00 ,  A61K31/194 ,  A61K31/198 ,  A61K31/472 ,  A61K31/7052 ,  A61K33/04 ,  A61K33/06 ,  A61K45/06 ,  A61K2300/00 ,  A23V2200/322 ,  A23V2250/30 ,  A23V2250/0606 ,  A23V2250/1626

摘要： Methods and materials related to the use of morphine, morphine precursors (e.g., reticuline), and inhibitors of morphine synthesis or activity to treat diseases, to reduce inflammation, or to restore normal function are provided.

摘要翻译： 提供了与使用吗啡，吗啡前体（如网状丝氨酸）以及吗啡合成抑制剂或治疗疾病，降低炎症或恢复正常功能有关的方法和材料。