公开(公告)号：US20150250687A1

公开(公告)日：2015-09-10

申请号：US14640809

申请日：2015-03-06

申请人： THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

发明人： CHRISTOPHER N. BOWMAN ,  WEIXIAN XI ,  SHUNSUKE CHATANI ,  TAO GONG ,  DEVATHA P. NAIR ,  MACIEJ PODGORSKI

IPC分类号： A61K6/087 ,  C08G75/20 ,  C08G18/38 ,  C08G18/73 ,  C08G18/67

CPC分类号： A61K6/087 ,  A61K6/0079 ,  C08G18/3876 ,  C08G18/677 ,  C08G18/73

摘要： The invention includes a composition comprising a vinyl sulfone monomer, a thiol monomer, and optionally an isocyanate monomer. The invention further includes a composition comprising a composition comprising the tetra(2-mercapto)silane (SiTSH) monomer and at least one selected from the group consisting of (a) a Michael acceptor, optionally an isocyanate monomer, and optionally at least one catalyst selected from the group consisting of a base, nucleophile, photolabile base, photolabile nucleophile, and mixtures thereof; (b) an ene monomer, and optionally a polymerization photoinitiator. In certain embodiments, once the composition is polymerized, the polymerized system is suitable for use as a dental composite system. In other embodiments, the polymerized system is stable to acidic and basic conditions. In yet other embodiments, the polymerized system forms microparticles. The invention further includes a method of generating a dental polymeric material.

摘要翻译： 本发明包括包含乙烯基砜单体，硫醇单体和任选的异氰酸酯单体的组合物。 本发明还包括一种组合物，其包含包含四（2-巯基）硅烷（SiTSH）单体和至少一种选自（a）迈克尔受体，任选的异氰酸酯单体和任选的至少一种催化剂 选自碱基，亲核试剂，光不稳定碱，光不稳定亲核试剂及其混合物; （b）烯单体和任选的聚合光引发剂。 在某些实施方案中，一旦组合物聚合，聚合体系适合用作牙科复合体系。 在其它实施方案中，聚合体系对酸性和碱性条件是稳定的。 在其它实施方案中，聚合体系形成微粒。 本发明还包括产生牙科聚合物材料的方法。