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公开(公告)号：US20220032074A1
公开(公告)日：2022-02-03
申请号：US17277616
申请日：2019-09-23
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Yama Akbari , Robert H. Wilson , Christian Crouzet , Bernard Choi , Bruce J. Tromberg
Abstract: Electrophysiologic biomarkers for prognostication of neurological outcome are described herein. An inverse correlation was found between timing of a cortical spreading depolarization (SD) wave and neurological outcome as tested at 24 hours post-CPR. Additionally, a minor image of this SD was identified as a “repolarization (RP) wave.” Quantifying features of SD and RP during cardiac arrest and cardiopulmonary resuscitation (CPR) provide important metrics for diagnosis and prognosis of neurological injury from hypoxia-ischemia and can serve as an early prognostication tool for predicting outcome at subsequent days after successful CPR. This discovery may also allow for novel therapeutic interventions to improve neurological recovery after hypoxia-ischemia insults.
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公开(公告)号：US10438346B2
公开(公告)日：2019-10-08
申请号：US15108279
申请日：2015-01-06
Applicant: The Regents of the University of California
Inventor： Kyle Nadeau , Anthony J. Durkin , Bruce J. Tromberg
Abstract: The present invention relates to methods and devices that may be used to extract spatial frequency information. In one embodiment, the invention provides an instrument configured to extract data using a two-dimensional (2D) Hilbert transform technique, and providing spatial frequency information from a sample. In another embodiment, the invention provides a spatial frequency domain imaging (SFDI) device adapted for demodulation using two or less imaging frames.
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3.发明申请公开(公告)号：US20180296168A1
公开(公告)日：2018-10-18
申请号：US15488263
申请日：2017-04-14
Inventor： Tyler Bywaters Rice , Michael Ghijsen , Bruce J. Tromberg , Bruce Yee Yang , Sean Michael White
Abstract: Systems and methods are disclosed for determining physiological information in a subject. The system includes: a light source positionable along a first location outside of the subject; a photo-sensitive detector positionable along a second location outside of the subject and configured to detect scattered light and generate a signal; a processor having a program and a memory, wherein the processor is operably coupled to the detector and configured to receive and store the signals generated over a period of time; wherein the processor is programmed to derive contrast metrics from the stored signals, calculate a waveform from the contrast metrics, decompose the waveform into basis functions and respective amplitudes, and compare the basis function amplitudes to determine the physiological information.
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公开(公告)号：US20160345858A1
公开(公告)日：2016-12-01
申请号：US15169426
申请日：2016-05-31
Applicant: The Regents of the University of California
Inventor： Bruce J. Tromberg , Kyle Cutler , Chris Van Wagenen , Seung-ha Lee , Thomas O'Sullivan , Gopi Meenakshisundaram , Aditi Majumder , Albert Cerussi
CPC classification number: A61B5/067 , A61B5/0075 , A61B5/062 , A61B5/064 , A61B5/065 , A61B5/1127 , A61B5/1128 , A61B2560/0223 , A61B2562/0219 , A61B2562/0223
Abstract: In accordance with various embodiments herein, disclosed herein is an apparatus comprising an imaging probe-based device operably linked to an automated tracking system. Furthermore, in various embodiments, the apparatus may be used to track the position and movement of a handheld imaging probe, including with respect to a subject's 3D surface profile. In one embodiment, a device may be used to track the position and movement of a handheld imaging probe with respect to a subject's 3D surface profile, while simultaneously acquiring optical data.
Abstract translation: 根据本文的各种实施例，本文公开了一种包括可操作地连接到自动跟踪系统的基于成像探针的装置的装置。 此外，在各种实施例中，该装置可以用于跟踪手持式成像探针的位置和移动，包括相对于受试者的3D表面轮廓。 在一个实施例中，可以使用装置来跟踪手持成像探针相对于被摄体的3D表面轮廓的位置和移动，同时获取光学数据。
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公开(公告)号：US20220192919A1
公开(公告)日：2022-06-23
申请号：US17690866
申请日：2022-03-09
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Robert H. Wilson , Christian Crouzet , Yama Akbari , Bernard Choi , Bruce J. Tromberg
IPC: A61H31/00 , A61B5/1455 , A61B5/0205 , A61B5/026
Abstract: A multimodal optical imaging platform is used to obtain cerebral perfusion-metabolism mismatch metrics for rapid assessment of acute brain injury, ongoing (real-time) feedback to optimize cardiopulmonary resuscitation to improve neurological outcome, and rapid prognosis of recovery. Light of several wavelengths and types is delivered to the tissue, which is then absorbed and scattered by tissue components such as blood and cellular components. Some of this light scatters back to the surface, where it is captured by a detector. The resulting data are processed to obtain blood flow and oxygenation parameters, as well as tissue scattering. These parameters are then combined to calculate metabolism and flow-metabolism coupling/decoupling metrics, which are used to determine ischemic damage, ongoing need for optimal blood flow and oxygenation, and to predict cerebral recovery in patients with acute brain injury during and immediately after cardiac arrest, stroke, traumatic brain injury, etc.
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Patent Agency Ranking
公开(公告)号：US10827974B2
公开(公告)日：2020-11-10
申请号：US15411674
申请日：2017-01-20
Applicant: The Regents of the University of California
Inventor： Robert Warren , Goutham Ganesan , Thomas O'Sullivan , Shaista Malik , Bruce J. Tromberg , Pietro Galassetti
IPC: A61B5/00 , A61B5/1455 , A61B5/145 , G16H50/20
Abstract: A quantitative, non-invasive optical spectroscopy technique for measuring dynamic changes in adipose tissue structure and metabolism in vivo. The technique requires multiple wavelengths of light in the near-infrared (650-1000 nm). Using these wavelengths of light, adipose tissue is illuminated and light that returns to a photodetector is analyzed. From the return signals, the absorption and reduced scattering coefficients (μa and μs′) at each wavelength are calculated. The obtained μa and μs′ values allow for quantification of biomarkers and indices which allow for measurement of fat composition and metabolism. The concentration of oxy- and deoxy-hemoglobin, the fractional water and lipid content, and information about the size distribution of light scatterers in the adipose tissue are also determined. A detailed and quantitative understanding of fat composition and metabolism is thereby provided which describes the effectiveness of interventions to improve the health of a patient.
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公开(公告)号：US10813597B2
公开(公告)日：2020-10-27
申请号：US15488263
申请日：2017-04-14
Applicant: The Regents of the University of California , Covidien LP
Inventor： Tyler Bywaters Rice , Michael Ghijsen , Bruce J. Tromberg , Bruce Yee Yang , Sean Michael White
Abstract: Systems and methods are disclosed for determining physiological information in a subject. The system includes: a light source positionable along a first location outside of the subject; a photo-sensitive detector positionable along a second location outside of the subject and configured to detect scattered light and generate a signal; a processor having a program and a memory, wherein the processor is operably coupled to the detector and configured to receive and store the signals generated over a period of time; wherein the processor is programmed to derive contrast metrics from the stored signals, calculate a waveform from the contrast metrics, decompose the waveform into basis functions and respective amplitudes, and compare the basis function amplitudes to determine the physiological information.
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公开(公告)号：US20170209083A1
公开(公告)日：2017-07-27
申请号：US15416942
申请日：2017-01-26
Applicant: The Regents of the University of California
Inventor： Soroush Mohammad Mirzaei Zarandi , Bruce J. Tromberg , Thomas D. O'Sullivan , Siavash Sedighzadeh Yazdi , Albert Cerussi
IPC: A61B5/1455 , A61B5/00 , A61B5/08 , A61B5/145 , A61B5/024
CPC classification number: A61B5/14551 , A61B5/02416 , A61B5/0816 , A61B5/14546 , A61B5/7278
Abstract: A low cost portable high speed quantitative system for diffuse optical spectroscopic imaging of human tissue. The hybrid system (CWFD) can measure absolute optical properties from 660 nm to 980 nm and recover all tissue chromophore concentrations. The standalone FD module can be utilized to measure scattering at every measurement and recover deoxygenated and oxygenated hemoglobin concentrations. The CW module can operate concurrently with the FD module to also measure water and lipid. The high temporal resolution and large signal-to-noise ratio of the CWFD system may be used to explore tissue oximetry, vascular occlusion, and paced breathing models to measure and analyze tissue hemodynamics response to changes in blood flow. Continuous monitoring of vasculature response to various modified blood perfusion conditions can provide information about local tissue metabolism and physiological state (dysfunction).
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公开(公告)号：US11160470B2
公开(公告)日：2021-11-02
申请号：US15169426
申请日：2016-05-31
Applicant: The Regents of the University of California
Inventor： Bruce J. Tromberg , Kyle Cutler , Chris Van Wagenen , Seung-ha Lee , Thomas O'Sullivan , Gopi Meenakshisundaram , Aditi Majumder , Albert Cerussi
Abstract: In accordance with various embodiments herein, disclosed herein is an apparatus comprising an imaging probe-based device operably linked to an automated tracking system. Furthermore, in various embodiments, the apparatus may be used to track the position and movement of a handheld imaging probe, including with respect to a subject's 3D surface profile. In one embodiment, a device may be used to track the position and movement of a handheld imaging probe with respect to a subject's 3D surface profile, while simultaneously acquiring optical data.
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公开(公告)号：US10653346B2
公开(公告)日：2020-05-19
申请号：US15416942
申请日：2017-01-26
Applicant: The Regents of the University of California
Inventor： Soroush Mohammad Mirzaei Zarandi , Bruce J. Tromberg , Thomas D. O'Sullivan , Siavash Sedighzadeh Yazdi , Albert Cerussi
IPC: A61B5/1455 , A61B5/145 , A61B5/024 , A61B5/08 , A61B5/00
Abstract: A low cost portable high speed quantitative system for diffuse optical spectroscopic imaging of human tissue. The hybrid system (CWFD) can measure absolute optical properties from 660 nm to 980 nm and recover all tissue chromophore concentrations. The standalone FD module can be utilized to measure scattering at every measurement and recover deoxygenated and oxygenated hemoglobin concentrations. The CW module can operate concurrently with the FD module to also measure water and lipid. The high temporal resolution and large signal-to-noise ratio of the CWFD system may be used to explore tissue oximetry, vascular occlusion, and paced breathing models to measure and analyze tissue hemodynamics response to changes in blood flow. Continuous monitoring of vasculature response to various modified blood perfusion conditions can provide information about local tissue metabolism and physiological state (dysfunction).
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