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公开(公告)号：US20190183558A1
公开(公告)日：2019-06-20
申请号：US16327266
申请日：2017-08-29
IPC分类号： A61B18/02
CPC分类号： A61B18/0218 , A61B18/02 , A61B2018/00101 , A61B2018/00166 , A61B2018/00452 , A61B2018/00559 , A61B2018/00577 , A61B2018/00672 , A61B2018/00678 , A61B2018/00714 , A61B2018/00791 , A61B2018/0262 , A61B2018/0293
摘要： Systems and methods for the use of cooling to trigger desirable effects of increased vasculature and/or development of new collagen in biological tissue are provided. In particular, the systems and methods provide a cooling treatment system configured to provide bulk or fractionated cooling at either at ablative temperatures or intermediary remodeling temperatures to promote tissue remodeling by inducing increased vasculature and/or the formation of new collagen.
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公开(公告)号：US20170274011A1
公开(公告)日：2017-09-28
申请号：US15505042
申请日：2015-08-27
IPC分类号： A61K33/00 , A61K47/10 , A61K47/18 , A61K47/28 , A61K31/137 , A61K31/045 , A61K31/167 , A61K31/445 , A61K31/245 , A61K9/00 , A61K45/06
摘要： One aspect of the invention provides a slurry comprising: a plurality of sterile ice particles having a largest cross-sectional dimension less than about 1.5 mm; and a biocompatible surfactant. Another aspect of the invention provides a slurry including: a plurality of sterile ice particles having a largest cross-sectional dimension less than about 1.5 mm; a biocompatible surfactant; and a foam comprising a plurality of gas bubbles. Another aspect of the invention provides a slurry including: a plurality of sterile ice particles having a largest cross-sectional dimension less than about 1.5 mm; and a biocompatible excipient. Another aspect of the invention provides a slurry including: a plurality of sterile ice particles having a largest cross-sectional dimension less than about 1.5 mm; and a lipolytic agent.
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公开(公告)号：US11938188B2
公开(公告)日：2024-03-26
申请号：US17188359
申请日：2021-03-01
IPC分类号： A61K45/06 , A61K9/00 , A61K31/045 , A61K31/047 , A61K31/137 , A61K31/167 , A61K31/245 , A61K31/445 , A61K31/7004 , A61K31/718 , A61K31/765 , A61K33/00 , A61K47/02 , A61K47/10 , A61K47/18 , A61K47/26 , A61K47/28
CPC分类号： A61K45/06 , A61K9/0019 , A61K9/0024 , A61K31/045 , A61K31/047 , A61K31/137 , A61K31/167 , A61K31/245 , A61K31/445 , A61K31/7004 , A61K31/718 , A61K31/765 , A61K33/00 , A61K47/02 , A61K47/10 , A61K47/18 , A61K47/26 , A61K47/28 , A61K33/00 , A61K2300/00 , A61K31/7004 , A61K2300/00 , A61K31/718 , A61K2300/00 , A61K31/047 , A61K2300/00 , A61K31/765 , A61K2300/00 , A61K31/137 , A61K2300/00 , A61K31/045 , A61K2300/00
摘要： One aspect of the invention provides a slurry comprising: a plurality of sterile ice particles having a largest cross-sectional dimension less than about 1.5 mm; and a biocompatible surfactant. Another aspect of the invention provides a slurry including: a plurality of sterile ice particles having a largest cross-sectional dimension less than about 1.5 mm; a biocompatible surfactant; and a foam comprising a plurality of gas bubbles. Another aspect of the invention provides a slurry including: a plurality of sterile ice particles having a largest cross-sectional dimension less than about 1.5 mm; and a biocompatible excipient. Another aspect of the invention provides a slurry including: a plurality of sterile ice particles having a largest cross-sectional dimension less than about 1.5 mm; and a lipolytic agent.
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公开(公告)号：US20240042034A1
公开(公告)日：2024-02-08
申请号：US18487887
申请日：2023-10-16
IPC分类号： A61K45/06 , A61K9/00 , A61K47/02 , A61K47/10 , A61K47/26 , A61K33/00 , A61K31/045 , A61K31/047 , A61K31/137 , A61K31/7004 , A61K31/718 , A61K31/765 , A61K31/167 , A61K31/245 , A61K31/445 , A61K47/18 , A61K47/28
CPC分类号： A61K45/06 , A61K9/0019 , A61K47/02 , A61K47/10 , A61K47/26 , A61K33/00 , A61K31/045 , A61K31/047 , A61K31/137 , A61K31/7004 , A61K31/718 , A61K31/765 , A61K9/0024 , A61K31/167 , A61K31/245 , A61K31/445 , A61K47/18 , A61K47/28
摘要： Described herein are compositions comprising, and methods for using, biocompatible cold slurries and methods of administering the same to provide reversible inhibition of peripheral nerves in a subject in need thereof.
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公开(公告)号：US20210244817A1
公开(公告)日：2021-08-12
申请号：US17188359
申请日：2021-03-01
IPC分类号： A61K45/06 , A61K9/00 , A61K47/02 , A61K47/10 , A61K47/26 , A61K33/00 , A61K31/045 , A61K31/047 , A61K31/137 , A61K31/7004 , A61K31/718 , A61K31/765 , A61K31/167 , A61K31/245 , A61K31/445 , A61K47/18 , A61K47/28
摘要： One aspect of the invention provides a slurry comprising: a plurality of sterile ice particles having a largest cross-sectional dimension less than about 1.5 mm; and a biocompatible surfactant. Another aspect of the invention provides a slurry including: a plurality of sterile ice particles having a largest cross-sectional dimension less than about 1.5 mm; a biocompatible surfactant; and a foam comprising a plurality of gas bubbles. Another aspect of the invention provides a slurry including: a plurality of sterile ice particles having a largest cross-sectional dimension less than about 1.5 mm; and a biocompatible excipient. Another aspect of the invention provides a slurry including: a plurality of sterile ice particles having a largest cross-sectional dimension less than about 1.5 mm; and a lipolytic agent.
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公开(公告)号：US12097282B2
公开(公告)日：2024-09-24
申请号：US17966668
申请日：2022-10-14
CPC分类号： A61K9/0019 , A61K33/00 , A61K47/10 , A61P9/00
摘要： A method for treating vascular diseases is provided. The method includes fabricating a sterile ice slurry including water and ice particles, cooling the sterile ice slurry to a predetermined temperature, and injecting the sterile ice slurry into a desired tissue region. The desired tissue region includes perivascular adipose tissue.
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公开(公告)号：US20220346852A1
公开(公告)日：2022-11-03
申请号：US17861138
申请日：2022-07-08
IPC分类号： A61B18/02
摘要： Systems and methods for the use of cooling to trigger desirable effects of increased vasculature and/or development of new collagen in biological tissue are provided. In particular, the systems and methods provide a cooling treatment system configured to provide bulk or fractionated cooling at either at ablative temperatures or intermediary remodeling temperatures to promote tissue remodeling by inducing increased vasculature and/or the formation of new collagen.
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公开(公告)号：US20170274078A1
公开(公告)日：2017-09-28
申请号：US15505039
申请日：2015-08-27
IPC分类号： A61K45/06 , A61K31/765 , A61K31/7004 , A61K31/718 , A61K31/047 , A61K31/137
CPC分类号： A61K45/06 , A61K9/0019 , A61K9/0024 , A61K31/045 , A61K31/047 , A61K31/137 , A61K31/167 , A61K31/245 , A61K31/445 , A61K31/7004 , A61K31/718 , A61K31/765 , A61K33/00 , A61K47/02 , A61K47/10 , A61K47/18 , A61K47/26 , A61K47/28 , A61K2300/00
摘要： Described herein are compositions comprising, and methods for using, biocompatible cold slurries and methods of administering the same to provide reversible inhibition of peripheral nerves in a subject in need thereof.
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公开(公告)号：US20230363940A1
公开(公告)日：2023-11-16
申请号：US18083427
申请日：2022-12-16
CPC分类号： A61F7/0085 , F25C1/12 , A61M5/158 , A61F2007/0063 , F25C2301/002 , A61M5/142
摘要： The present disclosure provides systems and method for medical ice slurry production. In particular, systems and methods are provided for medical ice slurry production that enable an end user to produce and deliver a sterile medical ice slurry at the point of care.
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公开(公告)号：US20230338276A1
公开(公告)日：2023-10-26
申请号：US17966668
申请日：2022-10-14
CPC分类号： A61K9/0019 , A61K33/00 , A61K47/10 , A61P9/00
摘要： A method for treating vascular diseases is provided. The method includes fabricating a sterile ice slurry including water and ice particles, cooling the sterile ice slurry to a predetermined temperature, and injecting the sterile ice slurry into a desired tissue region. The desired tissue region includes perivascular adipose tissue.
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