公开(公告)号：US11331272B2

公开(公告)日：2022-05-17

申请号：US16478278

申请日：2018-01-17

Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITED

Inventor： Chang Zhi Adrian Ng ,  Shen-Yi Ian Cheong

IPC: A61K9/127 ,  A61P35/00 ,  A61K31/517 ,  A61K31/519 ,  A61K47/02 ,  A61K47/12

Abstract: Hyperstable liposome comprising an anti-mitotic agent, one or more anions and one or more cations entrapped in the inner milieu, wherein the entrapped anti-mitotic drug is released at a slow rate that is less than 0.6% in 12 hours or less than 5% in 8 hours when the liposomes are suspended in 600 mM sucrose. These liposomes are useful in the treatment of cancer. In particular, HEPC:Chol:DSPE-PEG2000 (50:45:5) liposomes comprising BI 2536 and citrate:phosphate in a ratio of 1:3.