公开(公告)号：US12130219B2

公开(公告)日：2024-10-29

申请号：US16967033

申请日：2019-01-30

申请人： TECHNOLOGY INNOVATION MOMENTUM FUND (ISRAEL) LIMITED PARTNERSHIP

发明人： Itay Barnea ,  Natan Tzvi Shaked ,  Lidor Karako ,  Michal Balberg ,  Alon Shalev

IPC分类号： G01N15/0205 ,  G01N33/487 ,  G02B21/00

CPC分类号： G01N15/0205 ,  G01N33/48735 ,  G02B21/0056 ,  G02B21/0076

摘要： Methods and systems for evaluating fertility potential of a living sperm cell are presented and involve providing a predetermined classification function correlating between one or more physio spatial parameters of sperm cells and DNA fragmentation distribution in sperm cells, providing data indicative of the one or more physio spatial parameters of the living sperm cell, and applying the classification function to the one or more physio spatial parameters of the living sperm cell to thereby determine a DNA fragmentation level, inside the DNA fragmentation distribution, in the living sperm cell, the DNA fragmentation level being indicative of the fertility potential of the living sperm cell.

公开(公告)号：US10996214B2

公开(公告)日：2021-05-04

申请号：US15420445

申请日：2017-01-31

申请人： Technology Innovation Momentum Fund (Israel) Limited Partnership

发明人： Natan Tzvi Shaked ,  Pinhas Girshovitz ,  Itay Barnea ,  Michal Balberg ,  Simcha Mirsky ,  Pinkie Jacob Eravuchira

IPC分类号： G01N33/487 ,  G01N15/14 ,  G01N21/45 ,  B01L3/00 ,  G01B9/02 ,  G01B11/24 ,  G01N15/10 ,  G01N21/23

摘要： Methods and systems for use in sperm analysis are described. A method for processing measured data comprising at least interferometric phase data of label-free sperm cell(s), the processing comprising determining topographic optical phase delay map of the label-free sperm, determining at least one physical parameter of the label-free sperm, and generating data indicative of sperm quality for the label-free sperm. A device comprising a flow channel comprising an inlet for receiving fluid containing cells, a selection zone and at least two outlets at said selection zone; and a flow-driving mechanism comprising a flow-driving unit configured and operable to generate flow of said fluid from said inlet towards at least first of said at least two outlets, and a collecting driving unit selectively operating along the direction of a second outlet of said at least two outlets to direct a portion of interest of said fluid towards said second outlet.