公开(公告)号：US20190049708A1

公开(公告)日：2019-02-14

申请号：US16041922

申请日：2018-07-23

Applicant: TECAN TRADING AG

Inventor： Andreas ERLBACHER ,  Markus SCHÜRF ,  Josef GRASSL ,  Alexander KASER

IPC: G02B21/00 ,  G02B21/24 ,  G02B21/06 ,  G02B21/36

Abstract: A system 100 and method are provided for imaging a sample in a sample holder. For providing autofocus, a 2D pattern is projected onto the sample holder 050 via an astigmatic optical element 120. Image data 172 of the sample is acquired by an image sensor 140 via magnification optics 150. A difference in sharpness of the two-dimensional pattern in the image data is measured along a first axis and a second axis. Based on the difference, a magnitude and direction of defocus of the camera subsystem is determined with respect to the sample holder. This enables the sample holder, and thereby the sample, to be brought into focus in a fast and reliable manner.

公开(公告)号：US20180376048A1

公开(公告)日：2018-12-27

申请号：US16015363

申请日：2018-06-22

Applicant: TECAN TRADING AG

Inventor： Markus SCHÜRF ,  Frank MÜNCHOW ,  Christian OBERDANNER ,  Alexander KASER

IPC: H04N5/235 ,  H04N5/232 ,  H04N5/265

Abstract: An imaging system and method are provided in which a well of a microplate 050 is imaged by a camera 110 comprising magnification optics 112. The camera is controlled to acquire a series of images of the well with different exposures. The series of images comprise a base image with a base exposure and at least one further image with a larger exposure than the base exposure. The series of images are then merged into an output image which comprises in a center region of the well image content from the base image and at a peripheral region of the well image content from the at least one further image. Advantageously, the output image may allow for better assaying or analysis of the samples in the well than any of the individual images.

公开(公告)号：US20230147653A1

公开(公告)日：2023-05-11

申请号：US17982282

申请日：2022-11-07

Applicant: TECAN TRADING AG

Inventor： Volfgang VILAJ ,  Alexander KASER

IPC: G06T3/00 ,  G06T7/33 ,  G06T7/00 ,  G06T7/10

CPC classification number: G06T3/0068 ,  G06T7/10 ,  G06T7/0012 ,  G06T7/337 ,  G06T2207/20132 ,  G06T2207/20224

Abstract: Some embodiments are directed to image registration. A rotation angle is determined and subsequently a translation vector. The rotation angle and translation vector together defining an alignment transformation between a first image and a second image. Determining the rotation angle may include iterating over multiple potential rotation angles, and determining alignment.