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公开(公告)号：US12122815B2
公开(公告)日：2024-10-22
申请号：US17279266
申请日：2019-09-24
发明人： Hiroshi Imoto , Mari Adachi , Yoko Kanematsu , Taiji Asami , Ayumu Niida , Naoki Nishizawa , Derek Cecil Cole , Mack Flinspach , Nick Scorah , Abhijit Suresh Bhat
CPC分类号： C07K14/575 , A61K9/0019 , A61K9/08 , A61K9/2013 , A61K9/2018 , A61K9/2059 , A61K47/02 , A61P1/08 , A61K38/00
摘要： The present disclosure provides GIP receptor agonist peptide compounds having an activating action on GIP receptors and use of the GIP receptor agonist peptide as a medicament for the treatment and/or prevention of diabetes, obesity, emesis, or a symptom or condition associated with diabetes, obesity, or emesis. Specifically, a GIP receptor agonist peptide containing a sequence represented by the formula (I) or a salt thereof, and a medicament comprising the same are provided. Formula I: P1-A1-A2-A3-A4-A5-A6-A7-A8-A9-A10-A11-A12-A13-A14-A15-A16-A17-A18-A19-A20-A21-A22-A23-A24-A25-A26-A27-A28-A29-A30-A31-A32-A33-A34-A35-A36-A37-A38-A39-A40-A41-P2 (SEQ ID NO: 4), or a salt thereof, wherein each symbol is as defined herein, with the proviso that the GIP receptor agonist peptide does not have an amino acid sequence as provided in SEQ ID NOs: 328-893.
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公开(公告)号：US20220227830A1
公开(公告)日：2022-07-21
申请号：US17554539
申请日：2021-12-17
IPC分类号： C07K14/605 , A61K9/20 , A61K9/08 , A61K9/00 , A61P1/08
摘要： The present disclosure provides GIP receptor agonist peptide compounds suitable for once per day dosing (QD), said peptide compounds having an activating action on GIP receptors and use of the GIP receptor agonist peptide as a medicament for the treatment and/or prevention of emesis, or a symptom or condition associated with emesis. Specifically, a GIP receptor agonist peptide containing a sequence represented by any of the formulas (I)-(V) or a salt thereof, and a medicament comprising the same are provided.
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