PROCESS FOR THE PRODUCTION OF AMIDES
    3.
    发明申请
    PROCESS FOR THE PRODUCTION OF AMIDES 有权
    生产助剂的方法

    公开(公告)号:US20130253225A1

    公开(公告)日:2013-09-26

    申请号:US13889041

    申请日:2013-05-07

    摘要: The present invention relates to a process for the preparation of compounds of formula I wherein R1 and R2 are each independently of the other hydrogen or C1-C5alkyl and R3 is CF3 or CF2H, by a) reaction of a compound of formula II wherein R1 and R2 are as defined for formula I, with at least one reducing agent to form a compound of formula III wherein R1 and R2 are as defined for formula I, and b) reaction of that compound with at least one reducing agent to form a compound of formula IV wherein R1 and R2 are as defined for formula I, and (c) reaction of that compound with a compound of formula V wherein Q is chlorine, fluorine, bromine, iodine, hydroxy or C1-C6alkoxy and R3 is as defined for formula I, to form the compound of formula I; and to novel intermediates for use in that process.

    摘要翻译: 本发明涉及一种制备式Ⅰ化合物的方法,其中R1和R2分别独立地为氢或C1-C5烷基,R3为CF3或CF2H,通过a)式II化合物的反应其中R 1和 R 2如式I所定义,与至少一种还原剂形成式III化合物,其中R 1和R 2如式I所定义,和b)该化合物与至少一种还原剂的反应形成式 式IV其中R1和R2如式I所定义,和(c)该化合物与式V化合物的反应,其中Q是氯,氟,溴,碘,羟基或C 1 -C 6烷氧基,R 3如式 I,形成式I化合物; 以及用于该过程的新型中间体。

    PROCESS FOR THE PREPARATION OF BENZONORBORNENES
    10.
    发明申请
    PROCESS FOR THE PREPARATION OF BENZONORBORNENES 有权
    制备苯并噻唑的方法

    公开(公告)号:US20150141712A1

    公开(公告)日:2015-05-21

    申请号:US14603857

    申请日:2015-01-23

    IPC分类号: C07C17/32 C07C205/12

    摘要: The present invention relates to a novel a process for the preparation of 9-dichloromethylene-1,2,3,4-tetrahydro-1,4-methano-naphthalen-5-ylamine which process comprises a) reacting cyclopentadiene in the presence of a radical initiator and CXCl3, wherein X is chloro or bromo, to a compound of formula I1, or aa) reacting cyclopentadiene with CXCl3, wherein X is chloro, in the presence of a metal catalyst to a compound of formula I1, wherein X is chloro, b) reacting the compound of formula I1 with a base in the presence of an appropriate solvent to the compound of formula III, c) and converting the compound of formula III in the presence of 1,2-dehydro-6-nitrobenzene to the compound of formula IV, and d) hydrogenating the compound of formula IV in the presence of a metal catalyst.

    摘要翻译: 本发明涉及一种制备9-二氯亚甲基-1,2,3,4-四氢-1,4-亚甲基 - 萘-5-基胺的新方法,该方法包括:a)使环戊二烯在 自由基引发剂和其中X是氯或溴的CXCl 3,或aa)在金属催化剂存在下将环戊二烯与CXCl 3(其中X是氯)与式II化合物反应,其中X是氯 b)使式I1化合物与碱在适当的溶剂存在下反应,得到式III化合物,c)并在1,2-脱氢-6-硝基苯存在下将式III化合物转化为 式Ⅳ化合物,和d)在金属催化剂存在下氢化式Ⅳ化合物。