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公开(公告)号：US11485766B2
公开(公告)日：2022-11-01
申请号：US17134982
申请日：2020-12-28
发明人： Rajamannar Thennati , Nishith Chaturvedi , Vinod Sampatrao Burade , Pradeep Dinesh Shahi , Muthukumaran Natarajan , Ravishankara Madavati Nagaraja , Rishit Mansukhlal Zalawadia , Vipulkumar Shankarbhai Patel , Kunal Pandya , Brijeshkumar Patel , Dhiren Rameshchandra Joshi , Krunal Harishbhai Soni , Abhishek Tiwari
IPC分类号： C07K14/605 , A61K9/00 , A61P3/10 , A61P3/04 , A61K38/00
摘要： The present disclosure pertains to novel Glucagon like Peptide-1 (GLP-1) (7-37) analogs having an amino acid sequence with Leu or Ile at the C-terminal. The new analogs are potent GLP-1 agonists with reduced adverse effect and improved duration of action. The present disclosure further relates to acylated derivatives of the new analogs which have further improved potency and duration of action and are suitable for oral administration. The analogs of present disclosure may be useful in treatment of diabetes and obesity.
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公开(公告)号：US20190309040A1
公开(公告)日：2019-10-10
申请号：US16376190
申请日：2019-04-05
发明人： Rajamannar Thennati , Nishith Chaturvedi , Vinod Sampatrao Burade , Pradeep Dinesh Shahi , Muthukumaran Natarajan , Ravishankara Madavati Nagaraja , Rishit Mansukhlal Zalawadia , Vipulkumar Shankarbhai Patel , Kunal Pandya , Brijeshkumar Patel , Dhiren Rameshchandra Joshi , Krunal Harishbhai Soni , Abhishek Tiwari
IPC分类号： C07K14/605 , A61P3/04 , A61P3/10 , A61K9/00
摘要： The present disclosure pertains to novel Glucagon like Peptide-1 (GLP-1) (7-37) analogs having an amino acid sequence with Leu or Ile at the C-terminal. The new analogs are potent GLP-1 agonists with reduced adverse effect and improved duration of action. The present disclosure further relates to acylated derivatives of the new analogs which have further improved potency and duration of action and are suitable for oral administration. The analogs of present disclosure may be useful in treatment of diabetes and obesity.
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公开(公告)号：US11873328B2
公开(公告)日：2024-01-16
申请号：US17816577
申请日：2022-08-01
发明人： Rajamannar Thennati , Nishith Chaturvedi , Vinod Sampatrao Burade , Pradeep Dinesh Shahi , Muthukumaran Natarajan , Ravishankara Madavati Nagaraja , Rishit Mansukhlal Zalawadia , Vipulkumar Shankarbhai Patel , Kunal Pandya , Brijeshkumar Patel , Dhiren Rameshchandra Joshi , Krunal Harishbhai Soni , Abhishek Tiwari
IPC分类号： C07K14/605 , A61K9/00 , A61P3/10 , A61P3/04 , A61K38/00
CPC分类号： C07K14/605 , A61K9/0053 , A61P3/04 , A61P3/10 , A61K38/00
摘要： The present disclosure pertains to novel Glucagon like Peptide-1 (GLP-1) (7-37) analogs having an amino acid sequence with Leu or Ile at the C-terminal. The new analogs are potent GLP-1 agonists with reduced adverse effect and improved duration of action. The present disclosure further relates to acylated derivatives of the new analogs which have further improved potency and duration of action and are suitable for oral administration. The analogs of present disclosure may be useful in treatment of diabetes and obesity.
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公开(公告)号：US20220402992A1
公开(公告)日：2022-12-22
申请号：US17819466
申请日：2022-08-12
发明人： Rajamannar Thennati , Nishith Chaturvedi , Vinod Sampatrao Burade , Pradeep Dinesh Shahi , Muthukumaran Natarajan , Ravishankara Madavati Nagaraja , Rishit Mansukhlal Zalawadia , Vipulkumar Shankarbhai Patel , Kunal Pandya , Brijeshkumar Patel , Dhiren Rameshchandra Joshi , Krunal Harishbhai Soni , Abhishek Tiwari
IPC分类号： C07K14/605 , A61K9/00 , A61P3/10 , A61P3/04
摘要： The present disclosure pertains to novel Glucagon like Peptide-1 (GLP-1) (7-37) analogs having an amino acid sequence with Leu or Ile at the C-terminal. The new analogs are potent GLP-1 agonists with reduced adverse effect and improved duration of action. The present disclosure further relates to acylated derivatives of the new analogs which have further improved potency and duration of action and are suitable for oral administration. The analogs of present disclosure may be useful in treatment of diabetes and obesity.
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公开(公告)号：US20240199718A1
公开(公告)日：2024-06-20
申请号：US18515712
申请日：2023-11-21
发明人： Rajamannar Thennati , Nishith Chaturvedi , Vinod Sampatrao Burade , Pradeep Dinesh Shahi , Muthukumaran Natarajan , Ravishankara Madavati Nagaraja , Rishit Mansukhlal Zalawadia , Vipulkumar Shankarbhai Patel , Kunal Pandya , Brijeshkumar Patel , Dhiren Rameshchandra Joshi , Krunal Harishbhai Soni , Abhishek Tiwari
IPC分类号： C07K14/605 , A61K9/00 , A61K38/00 , A61P3/04 , A61P3/10
CPC分类号： C07K14/605 , A61K9/0053 , A61P3/04 , A61P3/10 , A61K38/00
摘要： The present disclosure pertains to novel Glucagon like Peptide-1 (GLP-1) (7-37) analogs having an amino acid sequence with Leu or Ile at the C-terminal. The new analogs are potent GLP-1 agonists with reduced adverse effect and improved duration of action. The present disclosure further relates to acylated derivatives of the new analogs which have further improved potency and duration of action and are suitable for oral administration. The analogs of present disclosure may be useful in treatment of diabetes and obesity.
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公开(公告)号：US11866477B2
公开(公告)日：2024-01-09
申请号：US17819466
申请日：2022-08-12
发明人： Rajamannar Thennati , Nishith Chaturvedi , Vinod Sampatrao Burade , Pradeep Dinesh Shahi , Muthukumaran Natarajan , Ravishankara Madavati Nagaraja , Rishit Mansukhlal Zalawadia , Vipulkumar Shankarbhai Patel , Kunal Pandya , Brijeshkumar Patel , Dhiren Rameshchandra Joshi , Krunal Harishbhai Soni , Abhishek Tiwari
IPC分类号： C07K14/605 , A61K9/00 , A61P3/10 , A61P3/04 , A61K38/00
CPC分类号： C07K14/605 , A61K9/0053 , A61P3/04 , A61P3/10 , A61K38/00
摘要： The present disclosure pertains to novel Glucagon like Peptide-1 (GLP-1) (7-37) analogs having an amino acid sequence with Leu or Ile at the C-terminal. The new analogs are potent GLP-1 agonists with reduced adverse effect and improved duration of action. The present disclosure further relates to acylated derivatives of the new analogs which have further improved potency and duration of action and are suitable for oral administration. The analogs of present disclosure may be useful in treatment of diabetes and obesity.
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公开(公告)号：US20220402991A1
公开(公告)日：2022-12-22
申请号：US17816577
申请日：2022-08-01
发明人： Rajamannar Thennati , Nishith Chaturvedi , Vinod Sampatrao Burade , Pradeep Dinesh Shahi , Muthukumaran Natarajan , Ravishankara Madavati Nagaraja , Rishit Mansukhlal Zalawadia , Vipulkumar Shankarbhai Patel , Kunal Pandya , Brijeshkumar Patel , Dhiren Rameshchandra Joshi , Krunal Harishbhai Soni , Abhishek Tiwari
IPC分类号： C07K14/605 , A61K9/00 , A61P3/10 , A61P3/04
摘要： The present disclosure pertains to novel Glucagon like Peptide-1 (GLP-1) (7-37) analogs having an amino acid sequence with Leu or Ile at the C-terminal. The new analogs are potent GLP-1 agonists with reduced adverse effect and improved duration of action. The present disclosure further relates to acylated derivatives of the new analogs which have further improved potency and duration of action and are suitable for oral administration. The analogs of present disclosure may be useful in treatment of diabetes and obesity.
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公开(公告)号：US11447535B2
公开(公告)日：2022-09-20
申请号：US16376190
申请日：2019-04-05
发明人： Rajamannar Thennati , Nishith Chaturvedi , Vinod Sampatrao Burade , Pradeep Dinesh Shahi , Muthukumaran Natarajan , Ravishankara Madavati Nagaraja , Rishit Mansukhlal Zalawadia , Vipulkumar Shankarbhai Patel , Kunal Pandya , Brijeshkumar Patel , Dhiren Rameshchandra Joshi , Krunal Harishbhai Soni , Abhishek Tiwari
IPC分类号： C07K14/605 , A61K9/00 , A61P3/10 , A61P3/04 , A61K38/00
摘要： The present disclosure pertains to novel Glucagon like Peptide-1 (GLP-1) (7-37) analogs having an amino acid sequence with Leu or Ile at the C-terminal. The new analogs are potent GLP-1 agonists with reduced adverse effect and improved duration of action. The present disclosure further relates to acylated derivatives of the new analogs which have further improved potency and duration of action and are suitable for oral administration. The analogs of present disclosure may be useful in treatment of diabetes and obesity.
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公开(公告)号：US11242373B2
公开(公告)日：2022-02-08
申请号：US16985207
申请日：2020-08-04
发明人： Rajamannar Thennati , Nishith Chaturvedi , Vinod Sampatrao Burade , Pradeep Dinesh Shahi , Muthukumaran Natarajan , Ravishankara Madavati Nagaraja , Rishit Mansukhlal Zalawadia , Vipulkumar Shankarbhai Patel , Kunal Pandya , Brijeshkumar Patel , Dhiren Rameshchandra Joshi , Krunal Harishbhai Soni , Abhishek Tiwari
摘要： The present disclosure pertains to novel Glucagon like Peptide-1 (GLP-1) (7-37) analogs having an amino acid sequence with Leu or Ile at the C-terminal. The new analogs are potent GLP-1 agonists with reduced adverse effect and improved duration of action. The present disclosure further relates to acylated derivatives of the new analogs which have further improved potency and duration of action and are suitable for oral administration. The analogs of present disclosure may be useful in treatment of diabetes and obesity.
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公开(公告)号：US20210206823A1
公开(公告)日：2021-07-08
申请号：US17134982
申请日：2020-12-28
发明人： Rajamannar Thennati , Nishith Chaturvedi , Vinod Sampatrao Burade , Pradeep Dinesh Shahi , Muthukumaran Natarajan , Ravishankara Madavati Nagaraja , Rishit Mansukhlal Zalawadia , Vipulkumar Shankarbhai Patel , Kunal Pandya , Brijeshkumar Patel , Dhiren Rameshchandra Joshi , Krunal Harishbhai Soni , Abhishek Tiwari
IPC分类号： C07K14/605 , A61K9/00 , A61P3/10 , A61P3/04
摘要： The present disclosure pertains to novel Glucagon like Peptide-1 (GLP-1) (7-37) analogs having an amino acid sequence with Leu or Ile at the C-terminal. The new analogs are potent GLP-1 agonists with reduced adverse effect and improved duration of action. The present disclosure further relates to acylated derivatives of the new analogs which have further improved potency and duration of action and are suitable for oral administration. The analogs of present disclosure may be useful in treatment of diabetes and obesity.
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