- 专利标题: NOVEL GLP-1 ANALOGUES
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申请号: US17816577申请日: 2022-08-01
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公开(公告)号: US20220402991A1公开(公告)日: 2022-12-22
- 发明人: Rajamannar Thennati , Nishith Chaturvedi , Vinod Sampatrao Burade , Pradeep Dinesh Shahi , Muthukumaran Natarajan , Ravishankara Madavati Nagaraja , Rishit Mansukhlal Zalawadia , Vipulkumar Shankarbhai Patel , Kunal Pandya , Brijeshkumar Patel , Dhiren Rameshchandra Joshi , Krunal Harishbhai Soni , Abhishek Tiwari
- 申请人: Sun Pharmaceutical Industries Limited
- 申请人地址: IN Mumbai
- 专利权人: Sun Pharmaceutical Industries Limited
- 当前专利权人: Sun Pharmaceutical Industries Limited
- 当前专利权人地址: IN Mumbai
- 优先权: IN201821013109 20180405,IN201821040468 20181026,IN201821040474 20181026
- 主分类号: C07K14/605
- IPC分类号: C07K14/605 ; A61K9/00 ; A61P3/10 ; A61P3/04
摘要:
The present disclosure pertains to novel Glucagon like Peptide-1 (GLP-1) (7-37) analogs having an amino acid sequence with Leu or Ile at the C-terminal. The new analogs are potent GLP-1 agonists with reduced adverse effect and improved duration of action. The present disclosure further relates to acylated derivatives of the new analogs which have further improved potency and duration of action and are suitable for oral administration. The analogs of present disclosure may be useful in treatment of diabetes and obesity.
公开/授权文献
- US11873328B2 GLP-1 analogues 公开/授权日:2024-01-16
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