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Patent Agency Ranking
1.发明申请Production method of 2-cyclohexyl- 2-hydroxy-2-phenylacetic acid intermediate therefor and production method thereof 失效2-环己基-2-羟基-2-苯乙酸中间体的制备方法及其制备方法公开(公告)号：US20030013911A1
公开(公告)日：2003-01-16
申请号：US09992167
申请日：2001-11-06
Applicant: Sumika Fine Chemicals Co., Ltd.
Inventor： Tetsuya Ikemoto , Wei-Guo Gao , Mitsuhiro Takeda , Masami Igi
IPC: C07C059/54
CPC classification number: C07C69/732 , C07C51/09 , C07C51/36 , C07C67/303 , C07C67/343 , C07C59/54
Abstract: The present invention relates to production of 2-cyclohexyl-2-hydroxy-2-phenylacetic acid useful as an intermediate for pharmaceutical products, by an industrial means, economically, safely in a good yield. Novel 2-(2null-cyclohexen-1null-yl)-2-hydroxy-2-phenylacetic acid ester obtained by reacting cyclohexene and benzoylformic acid ester in the presence of a Lewis acid is hydrolyzed and reduced to give 2-cyclohexyl-2-hydroxy-2-phenylacetic acid.
Abstract translation: 本发明涉及通过工业方式生产可用作药物产品中间体的2-环己基-2-羟基-2-苯乙酸，经济地，安全地以良好的收率产生。 在路易斯酸存在下，通过环己烯和苯甲酰甲酸酯反应得到的2-（2'-环己烯-1'-基）-2-羟基-2-苯基乙酸酯水解并还原，得到2-环己基-2 - 羟基-2-苯基乙酸。
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2.发明申请Production method of citalopram, intermediate therefor and production method of the intermediate 失效西酞普兰的生产方法，中间体和中间体的生产方法公开(公告)号：US20040138497A1
公开(公告)日：2004-07-15
申请号：US10744734
申请日：2003-12-23
Applicant: Sumika Fine Chemicals Co., Ltd.
Inventor： Tetsuya Ikemoto , Wei-Guo Gao , Masami Igi
IPC: C07C062/38
CPC classification number: C07D307/87 , C07C29/40 , C07C33/46 , C07C51/265 , C07C51/373 , C07C65/34
Abstract: Citalopram can be industrially and economically produced and at a high yield by reacting a compound of the following formula nullVInull with 3-(dimethylamino)propyl chloride in the presence of at least one of N,N,Nnull,Nnull-tetramethylethylenediamine and 1,3-dimethyl-2-imidazolidinone and a condensing agent. The compound of the following formula nullIIInull, which is a key compound for the production of citalopram, can be easily produced by subjecting the compound of the following formula nullIInull to reduction and cyclization. 1
Abstract translation: 通过在N，N，N'，N'-四甲基乙二胺中的至少一种的存在下使下式[Ⅵ]化合物与3-（二甲基氨基）丙基氯反应，可以工业和经济地制备，并以高收率 和1,3-二甲基-2-咪唑啉酮和缩合剂。 通过使下式[Ⅱ]的化合物还原和环化，可以容易地制备作为西酞普兰生产的关键化合物的下式[III]的化合物。
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3.发明申请公开(公告)号：US20040230066A1
公开(公告)日：2004-11-18
申请号：US10867350
申请日：2004-06-14
Applicant: Sumika Fine Chemicals Co., Ltd.
Inventor： Tetsuya Ikemoto , Wei-Guo Gao , Masami Igi
IPC: C07C051/16 , C07D307/02 , C07C033/36
CPC classification number: C07D307/87 , C07C29/40 , C07C33/46 , C07C51/265 , C07C51/373 , C07C65/34
Abstract: Citalopram can be industrially and economically produced and at a high yield by reacting a compound of the following formula nullVInull with 3-(dimethylamino)propyl chloride in the presence of at least one of N,N,Nnull,Nnull-tetramethylethylenediamine and 1,3-dimethyl-2-imidazolidinone and a condensing agent. The compound of the following formula nullIIInull, which is a key compound for the production of citalopram, can be easily produced by subjecting the compound of the following formula nullIInull to reduction and cyclization. 1
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4.发明申请公开(公告)号：US20020095051A1
公开(公告)日：2002-07-18
申请号：US10086076
申请日：2002-02-28
Applicant: Sumika Fine Chemicals Co., Ltd.
Inventor： Tetsuya Ikemoto , Wei-Guo Gao , Nobuhiro Arai , Masami Igi
IPC: C07C051/16 , C07C033/18
CPC classification number: C07D307/87 , C07C29/40 , C07C33/46 , C07C51/265 , C07C51/373 , C07C65/34
Abstract: Citalopram can be industrially and economically produced and at a high yield by reacting a compound of the following formula nullVInull with 3-(dimethylamino)propyl chloride in the presence of at least one of N,N,Nnull,Nnull-tetramethylethylenediamine and 1,3-dimethyl-2-imidazolidinone and a condensing agent. The compound of the following formula nullIIInull, which is a key compound for the production of citalopram, can be easily produced by subjecting the compound of the following formula nullIInull to reduction and cyclization. 1
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5.发明申请PRODUCTION METHOD OF CITALOPRAM, INTERMMEDIATE THEREFOR AND PRODUCTION METHOD OF THE INTERMEDIATE 失效CITALOPRAM的生产方法，其间接方法和中间件的生产方法公开(公告)号：US20020062040A1
公开(公告)日：2002-05-23
申请号：US09996134
申请日：2001-11-28
Applicant: Sumika Fine Chemicals Co., Ltd.
Inventor： Tetsuya Ikemoto , Wei-Guo Gao , Nobuhiro Arai , Masami Igi
IPC: C07C065/32 , C07C033/28
CPC classification number: C07D307/87 , C07C29/40 , C07C33/46 , C07C51/265 , C07C51/373 , C07C65/34
Abstract: Citalopram can be industrially and economically produced and at a high yield by reacting a compound of the following formula nullVInull with 3-(dimethylamino)propyl chloride in the presence of at least one of N,N,Nnull,Nnull-tetramethylethylenediamine and 1,3-dimethyl-2-imidazolidinone and a condensing agent. The compound of the following formula nullIIInull, which is a key compound for the production of citalopram, can be easily produced by subjecting the compound of the following formula nullIInull to reduction and cyclization. 1
Abstract translation: 通过在N，N，N'，N'-四甲基乙二胺中的至少一种的存在下使下式[Ⅵ]化合物与3-（二甲基氨基）丙基氯反应，可以工业和经济地制备，并以高收率 和1,3-二甲基-2-咪唑啉酮和缩合剂。 通过使下式[Ⅱ]的化合物还原和环化，可以容易地制备作为西酞普兰生产的关键化合物的下式[III]的化合物。
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