公开(公告)号：US20030013911A1

公开(公告)日：2003-01-16

申请号：US09992167

申请日：2001-11-06

Applicant: Sumika Fine Chemicals Co., Ltd.

Inventor： Tetsuya Ikemoto ,  Wei-Guo Gao ,  Mitsuhiro Takeda ,  Masami Igi

IPC: C07C059/54

CPC classification number: C07C69/732 ,  C07C51/09 ,  C07C51/36 ,  C07C67/303 ,  C07C67/343 ,  C07C59/54

Abstract: The present invention relates to production of 2-cyclohexyl-2-hydroxy-2-phenylacetic acid useful as an intermediate for pharmaceutical products, by an industrial means, economically, safely in a good yield. Novel 2-(2null-cyclohexen-1null-yl)-2-hydroxy-2-phenylacetic acid ester obtained by reacting cyclohexene and benzoylformic acid ester in the presence of a Lewis acid is hydrolyzed and reduced to give 2-cyclohexyl-2-hydroxy-2-phenylacetic acid.

Abstract translation: 本发明涉及通过工业方式生产可用作药物产品中间体的2-环己基-2-羟基-2-苯乙酸，经济地，安全地以良好的收率产生。 在路易斯酸存在下，通过环己烯和苯甲酰甲酸酯反应得到的2-（2'-环己烯-1'-基）-2-羟基-2-苯基乙酸酯水解并还原，得到2-环己基-2 - 羟基-2-苯基乙酸。