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    Use of inhibitors of toll-like receptors in the prevention and treatment of hypercholesterolemia and hyperlipidemia and diseases related thereto
    1.
    发明授权
    Use of inhibitors of toll-like receptors in the prevention and treatment of hypercholesterolemia and hyperlipidemia and diseases related thereto 有权
    使用粪便样受体抑制剂预防和治疗高胆固醇血症和高脂血症及其相关疾病

    公开(公告)号：US08853177B2

    公开(公告)日：2014-10-07

    申请号：US12574576

    申请日：2009-10-06

    申请人： Fu-Gang Zhu ,  Ekambar Kandimalla ,  Sudhir Agrawal

    发明人： Fu-Gang Zhu ,  Ekambar Kandimalla ,  Sudhir Agrawal

    IPC分类号： A61K48/00 ,  C07H21/02 ,  C07H21/04

    CPC分类号： A61K31/4706 ,  A61K31/7088

    摘要： The invention provides the use of TLR inhibitors or a pharmaceutically acceptable derivative thereof, optionally in combination with one or more lipid lowering composition, cholesterol lowering composition, diuretics, non-steroidal anti-inflammatory compounds (NSAIDs), antibodies, antisense oligonucleotides, TLR agonists, TLR antagonists, peptides, proteins or gene therapy vectors or combinations thereof for the prevention or treatment of hypercholesterolemia and/or hyperlipidemia and/or diseases associated therewith.

    摘要翻译： 本发明提供TLR抑制剂或其药学上可接受的衍生物的用途，任选地与一种或多种降脂组合物，降胆固醇组合物，利尿剂，非甾体抗炎化合物（NSAID），抗体，反义寡核苷酸，TLR激动剂组合 ，TLR拮抗剂，肽，蛋白质或基因治疗载体或其组合，用于预防或治疗高胆固醇血症和/或高脂血症和/或与之相关的疾病。

    Agonists of toll-like receptor 3 and methods of their use
    2.
    发明授权
    Agonists of toll-like receptor 3 and methods of their use 有权
    通畅型受体3的激动剂及其使用方法

    公开(公告)号：US08492358B2

    公开(公告)日：2013-07-23

    申请号：US13168494

    申请日：2011-06-24

    申请人： Ekambar Kandimalla ,  Tao Lan ,  Victoria Jane Philbin ,  Sudhir Agrawal

    发明人： Ekambar Kandimalla ,  Tao Lan ,  Victoria Jane Philbin ,  Sudhir Agrawal

    IPC分类号： C12N15/11 ,  A61K49/00

    CPC分类号： A61K39/39 ,  A61K2039/55561 ,  C12N15/117 ,  C12N2310/17 ,  C12N2310/315

    摘要： TLR3 agonist compounds, compositions and methods are provided for stimulating the activity of TLR3. The compositions comprise oligonucleotide-based compounds that bind to and activate TLR3. The compositions may also comprise oligonucleotide-based compounds that bind to and activate TLR3 in combination with other therapeutic and/or prophylactic compounds and/or compositions. Methods of using these compounds and compositions for stimulation of TLR3 activity and for prevention or treatment of diseases wherein modulation of TLR3 activity would be beneficial are provided.

    摘要翻译： 提供TLR3激动剂化合物，组合物和方法用于刺激TLR3的活性。 组合物包含与TLR3结合并激活TLR3的基于寡核苷酸的化合物。 组合物还可以包含与其它治疗和/或预防化合物和/或组合物组合结合并活化TLR3的基于寡核苷酸的化合物。 提供了使用这些化合物和组合物刺激TLR3活性和预防或治疗TLR3活性调节有益的疾病的方法。

    Immunostimulatory properties of oligonucleotide-based compounds comprising modified immunostimulatory dinucleotides
    7.
    发明授权
    Immunostimulatory properties of oligonucleotide-based compounds comprising modified immunostimulatory dinucleotides 失效
    包含修饰的免疫刺激二核苷酸的基于寡核苷酸的化合物的免疫刺激性质

    公开(公告)号：US07776834B2

    公开(公告)日：2010-08-17

    申请号：US11268714

    申请日：2005-11-07

    申请人： Sudhir Agrawal ,  Dong Yu ,  Ekambar Kandimalla

    发明人： Sudhir Agrawal ,  Dong Yu ,  Ekambar Kandimalla

    IPC分类号： A61K31/70 ,  A61K38/00 ,  A61K37/18 ,  A61K39/00 ,  A61K39/35 ,  A61K39/36 ,  A01N43/04 ,  C07H21/02 ,  C07H21/04

    CPC分类号： A61K31/70

    摘要： The invention relates to the therapeutic use of oligonucleotides as immunostimulatory agents in immunotherapy applications. More particularly, the invention provides an immunostimulatory oligonucleotides for use in methods for generating an immune response or for treating a patient in need of immunostimulation. The immunostimulatory oligonucleotides of the invention preferably comprise novel purines. The immunostimulatory oligonucleotides according to the invention further comprise at least two oligonucleotides linked at their 3′ ends, internucleoside linkages or functionalized nucleobase or sugar to a non-nucleotidic linker, at least one of the oligonucleotides being an immunostimulatory oligonucleotide and having an accessible 5′ end.

    摘要翻译： 本发明涉及在免疫治疗应用中寡核苷酸作为免疫刺激剂的治疗用途。 更具体地，本发明提供了用于产生免疫应答的方法或用于治疗需要免疫刺激的患者的免疫刺激性寡核苷酸。 本发明的免疫刺激性寡核苷酸优选包含新的嘌呤。 根据本发明的免疫刺激性寡核苷酸还包含至少两个在其3'末端连接的寡核苷酸，核苷间键或官能化核碱基或糖与非核酸连接体，至少一个寡核苷酸是免疫刺激性寡核苷酸并具有可接近的5' 结束。