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公开(公告)号：US20100098632A1
公开(公告)日：2010-04-22
申请号：US12373485
申请日：2007-07-12
申请人： Stephen J. Russell , Kah-Whye Peng , Hooi Tin Ong
发明人： Stephen J. Russell , Kah-Whye Peng , Hooi Tin Ong
IPC分类号： A61K51/04 , C07F5/00 , C07K16/00 , A61P35/00 , A61K31/663
CPC分类号： A61K51/0489 , A61F2/28 , A61F2310/00293 , A61K51/1027 , A61K51/1244
摘要： This document provides methods and materials related to hydroxyapatite particles. For example, hydroxyapatite particles, methods for making hydroxyapatite particles, and methods for using hydroxyapatite particles are provided herein.
摘要翻译： 本文件提供了与羟基磷灰石颗粒相关的方法和材料。 例如，提供羟基磷灰石颗粒，制备羟基磷灰石颗粒的方法，以及使用羟基磷灰石颗粒的方法。
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公开(公告)号：US07670598B2
公开(公告)日：2010-03-02
申请号：US12135721
申请日：2008-06-09
CPC分类号： A61K35/768 , C12N2760/18432
摘要： A method for treating cancer cells is provided comprising directly or systemically administering a therapeutically effective dose of an attenuated measles virus. In one embodiment, the therapeutically effective dose is from about 103 pfus to about 1012 pfus and is delivered by direct injection into a group of cancer cells or via intravenous injection.
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3.发明授权Method for limiting the growth of cancer cells using an attenuated measles virus 有权使用减毒麻疹病毒来限制癌细胞生长的方法公开(公告)号：US07854928B2
公开(公告)日：2010-12-21
申请号：US12688623
申请日：2010-01-15
CPC分类号： A61K35/768 , C12N2760/18432
摘要： A method for treating cancer cells is provided comprising directly or systemically administering a therapeutically effective dose of an attenuated measles virus. In one embodiment, the therapeutically effective dose is from about 103 pfus to about 1012 pfus and is delivered by direct injection into a group of cancer cells or via intravenous injection.
摘要翻译： 提供了治疗癌细胞的方法，其包括直接或全身施用治疗有效剂量的减毒麻疹病毒。 在一个实施方案中，治疗有效剂量为约103pfus至约1012pfus，并通过直接注射递送至一组癌细胞或通过静脉内注射。
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4.发明授权Method for limiting the growth of cancer cells using an attenuated measles virus 有权使用减毒麻疹病毒来限制癌细胞生长的方法公开(公告)号：US07393527B2
公开(公告)日：2008-07-01
申请号：US11532879
申请日：2006-09-18
CPC分类号： A61K35/768 , C12N2760/18432
摘要： A method for treating cancer cells is provided comprising directly or systemically administering a therapeutically effective dose of an attenuated measles virus. In one embodiment, the therapeutically effective dose is from about 103 pfus to about 1012 pfus and is delivered by direct injection into a group of cancer cells or via intravenous injection.
摘要翻译： 提供了治疗癌细胞的方法，其包括直接或全身施用治疗有效剂量的减毒麻疹病毒。 在一个实施方案中，治疗有效剂量为约10 3 pfus至约10 12 pfus，并通过直接注射递送至一组癌细胞或通过静脉内注射。
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5.发明申请公开(公告)号：US20050214218A1
公开(公告)日：2005-09-29
申请号：US11125940
申请日：2005-05-09
CPC分类号： C07K16/2896 , A61K2039/505 , C07K14/485 , C07K14/5434 , C07K14/65 , C07K16/3007 , C07K2317/622 , C07K2319/00
摘要： The invention relates to compositions and methods for treating a patient having a tumor in order to reduce tumor size, comprising administering to the patient a replication-competent Paramyxoviridae virus comprising two or more of a) a nucleic acid sequence encoding a heterologous polypeptide, wherein upon administration the heterologous polypeptide is detectable in a biological fluid of the patient, and detection of the heterologous polypeptide is indicative of Paramyxoviridae virus growth in the patient and reduction in tumor size; b) a recombinant F protein, H protein, or M protein of Paramyxoviridae virus that increases fusogenicity of virus with cells; c) a nucleic acid sequence encoding a cytokine; and d) a Paramyxoviridae virus that is specific for cells of the tumor.
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6.发明申请METHOD FOR LIMITING THE GROWTH OF CANCER CELLS USING AN ATTENUATED MEASLES VIRUS 有权使用衰减的测量病毒限制癌细胞生长的方法公开(公告)号：US20100119548A1
公开(公告)日：2010-05-13
申请号：US12688623
申请日：2010-01-15
IPC分类号： A61K39/295 , A61K45/00 , A61K39/165 , A61P37/04 , A61P35/00
CPC分类号： A61K35/768 , C12N2760/18432
摘要： A method for treating cancer cells is provided comprising directly or systemically administering a therapeutically effective dose of an attenuated measles virus. In one embodiment, the therapeutically effective dose is from about 103 pfus to about 1012 pfus and is delivered by direct injection into a group of cancer cells or via intravenous injection.
摘要翻译： 提供了治疗癌细胞的方法，其包括直接或全身施用治疗有效剂量的减毒麻疹病毒。 在一个实施方案中，治疗有效剂量为约103pfus至约1012pfus，并通过直接注射递送至一组癌细胞或通过静脉内注射。
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7.发明申请METHOD FOR LIMITING THE GROWTH OF CANCER CELLS USING AN ATTENUATED MEASLES VIRUS 有权使用衰减的测量病毒限制癌细胞生长的方法公开(公告)号：US20090004149A1
公开(公告)日：2009-01-01
申请号：US12135721
申请日：2008-06-09
CPC分类号： A61K35/768 , C12N2760/18432
摘要： A method for treating cancer cells is provided comprising directly or systemically administering a therapeutically effective dose of an attenuated measles virus. In one embodiment, the therapeutically effective dose is from about 103 pfus to about 1012 pfus and is delivered by direct injection into a group of cancer cells or via intravenous injection.
摘要翻译： 提供了治疗癌细胞的方法，其包括直接或全身施用治疗有效剂量的减毒麻疹病毒。 在一个实施方案中，治疗有效剂量为约103pfus至约1012pfus，并通过直接注射递送至一组癌细胞或通过静脉内注射。
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8.发明申请METHOD FOR LIMITING THE GROWTH OF CANCER CELLS USING AN ATTENUATED MEASLES VIRUS 有权使用衰减的测量病毒限制癌细胞生长的方法公开(公告)号：US20070071771A1
公开(公告)日：2007-03-29
申请号：US11532879
申请日：2006-09-18
申请人： Stephen Russell , Adele Fielding , Kah-Whye Peng , Deanna Grote
发明人： Stephen Russell , Adele Fielding , Kah-Whye Peng , Deanna Grote
IPC分类号： A61K39/165
CPC分类号： A61K35/768 , C12N2760/18432
摘要： A method for treating cancer cells is provided comprising directly or systemically administering a therapeutically effective dose of an attenuated measles virus. In one embodiment, the therapeutically effective dose is from about 103 pfus to about 1012 pfus and is delivered by direct injection into a group of cancer cells or via intravenous injection.
摘要翻译： 提供了治疗癌细胞的方法，其包括直接或全身施用治疗有效剂量的减毒麻疹病毒。 在一个实施方案中，治疗有效剂量为约10 3 pfus至约10 12 pfus，并通过直接注射递送至一组癌细胞或通过静脉内注射。
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9.发明授权Method for limiting the growth of cancer cells using an attenuated measles virus 有权使用减毒麻疹病毒来限制癌细胞生长的方法公开(公告)号：US07118740B1
公开(公告)日：2006-10-10
申请号：US09668196
申请日：2000-09-22
CPC分类号： A61K35/768 , C12N2760/18432
摘要： A method for treating cancer cells is provided comprising directly or systemically administering a therapeutically effective dose of an attenuated measles virus. In one embodiment, the therapeutically effective dose is from about 103 pfus to about 1012 pfus and is delivered by direct injection into a group of cancer cells or via intravenous injection.
摘要翻译： 提供了治疗癌细胞的方法，其包括直接或全身施用治疗有效剂量的减毒麻疹病毒。 在一个实施方案中，治疗有效剂量为约10 3 pfus至约10 12 pfus，并通过直接注射递送至一组癌细胞或通过静脉内注射。
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10.发明授权Therapeutic methods and compositions using viruses of the recombinant paramyxoviridae family 有权使用重组副粘病毒科的病毒的治疗方法和组合物公开(公告)号：US06896881B1
公开(公告)日：2005-05-24
申请号：US09667947
申请日：2000-09-22
IPC分类号： C07K14/485 , C07K14/54 , C07K14/65 , C07K16/28 , C07K16/30 , A01N63/00 , A61K39/00 , A61K39/165 , C12N15/00 , C12Q1/68
CPC分类号： C07K16/2896 , A61K2039/505 , C07K14/485 , C07K14/5434 , C07K14/65 , C07K16/3007 , C07K2317/622 , C07K2319/00
摘要： The invention relates to compositions and methods for treating a patient having a tumor in order to reduce tumor size, comprising administering to the patient a replication-competent Paramyxoviridae virus comprising two or more of a) a nucleic acid sequence encoding a heterologous polypeptide, wherein upon administration the heterologous polypeptide is detectable in a biological fluid of the patient, and detection of the heterologous polypeptide is indicative of Paramyxoviridae virus growth in the patient and reduction in tumor size; b) a recombinant F protein, H protein, or M protein of Paramyxoviridae virus that increases fusogenicity of virus with cells; c) a nucleic acid sequence encoding a cytokine; and d) a Paramyxoviridae virus that is specific for cells of the tumor.
摘要翻译： 本发明涉及用于治疗具有肿瘤的患者以减少肿瘤大小的组合物和方法，包括向患者施用包含两个或更多个a）编码异源多肽的核酸序列的可复制的副粘病毒科病毒，其中在 施用异源多肽在患者的生物流体中是可检测的，并且异源多肽的检测指示患者中副粘病毒病毒生长并减少肿瘤大小; b）副细菌病毒的重组F蛋白，H蛋白或M蛋白，其增加病毒与细胞的融合性; c）编码细胞因子的核酸序列; 和d）对于肿瘤细胞特异的副粘病毒科病毒。
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