公开(公告)号：US20050220822A1

公开(公告)日：2005-10-06

申请号：US11133963

申请日：2005-05-20

Applicant: Stephen Hoffman ,  Thomas Luke

Inventor： Stephen Hoffman ,  Thomas Luke

IPC: A61K39/015

CPC classification number: A61K39/015 ,  A61K2039/51 ,  A61K2039/523 ,  A61K2039/5256 ,  A61K2039/53 ,  A61K2039/54 ,  Y02A50/412

Abstract: The invention comprises novel compositions and methods for protecting subjects against malaria. The compositions of the invention include aseptic, live attenuated Plasmodium sporozoites, and the methods include the inoculation of subjects with these compositions by means of parenteral, non-intravenous inoculation, in particular, but not limited to subcutaneous, intramuscular, intradermal, mucosal, submucosal, and cutaneous administration.

Abstract translation: 本发明包括用于保护受试者免受疟疾的新型组合物和方法。 本发明的组合物包括无菌的活减毒疟原虫子孢子，并且所述方法包括通过肠胃外，非静脉内接种，特别是但不限于皮下，肌内，皮内，粘膜，粘膜下的接种具有这些组合物的受试者 ，皮肤给药。

公开(公告)号：US20050100532A1

公开(公告)日：2005-05-12

申请号：US10958163

申请日：2004-10-04

Applicant: Stephen Hoffman ,  Thomas Luke

Inventor： Stephen Hoffman ,  Thomas Luke

IPC: A01K67/00 ,  A01K67/033 ,  A61B17/20 ,  A61K39/015 ,  A61P33/06 ,  A01N63/04 ,  C12N1/10

CPC classification number: A01K67/033

Abstract: Disclosed are apparatuses and methods for the production of attenuated aseptic parasites in haematophagous insects generally, and production of Plasmodium species sporozoites in Anopheles species mosquitoes specifically; apparatuses and methods for the production of strains of haematophagous insects with desired properties such as hypoallergenicity or hyperinfectivity; methods of producing a parasite strain that is capable of withstanding cyropreservation at temperatures close to freezing; apparatuses and methods for the injection of an attenuated parasite vaccine; production of parasites and haematophagous insects that are free from contamination by unwanted biological agents; apparatuses for the reconstruction of complex parasitic life cycles aseptically to avoid the contamination of the parasite or the insect vector host with unwanted biological agents.

Abstract translation: 公开了通常在血虫中生产减毒无菌寄生虫的装置和方法，特别是在按蚊种中产生疟原虫种子孢子; 用于生产具有所需性质如低致敏性或超感染性的血液昆虫菌株的装置和方法; 生产能够在接近冷冻的温度下耐受静脉保存的寄生虫菌株的方法; 用于注射减毒寄生虫疫苗的装置和方法; 生产不受不需要的生物制剂污染的寄生虫和血液昆虫; 用于无菌地重建复杂寄生生命周期的装置，以避免寄生虫或昆虫载体宿主与不想要的生物制剂的污染。

公开(公告)号：US20070169209A1

公开(公告)日：2007-07-19

申请号：US11726622

申请日：2007-03-21

Applicant: Stephen Hoffman ,  Thomas Luke

Inventor： Stephen Hoffman ,  Thomas Luke

IPC: A01K67/033 ,  C12N1/10

CPC classification number: A01K67/033

Abstract: Disclosed are apparatuses and methods for the production of attenuated aseptic parasites in haematophagous insects generally, and production of Plasmodium species sporozoites in Anopheles species mosquitoes specifically; apparatuses and methods for the production of strains of haematophagous insects with desired properties such as hypoallergenicity or hyperinfectivity; methods of producing a parasite strain that is capable of withstanding cyropreservation at temperatures close to freezing; apparatuses and methods for the injection of an attenuated parasite vaccine; production of parasites and haematophagous insects that are free from contamination by unwanted biological agents; apparatuses for the reconstruction of complex parasitic life cycles aseptically to avoid the contamination of the parasite or the insect vector host with unwanted biological agents.

Abstract translation: 公开了通常在血虫中生产减毒无菌寄生虫的装置和方法，特别是在按蚊种中产生疟原虫种子孢子; 用于生产具有所需性质如低致敏性或超感染性的血液昆虫菌株的装置和方法; 生产能够在接近冷冻的温度下耐受静脉保存的寄生虫菌株的方法; 用于注射减毒寄生虫疫苗的装置和方法; 生产不受不需要的生物制剂污染的寄生虫和血液昆虫; 用于无菌地重建复杂寄生生命周期的装置，以避免寄生虫或昆虫载体宿主与不想要的生物制剂的污染。

公开(公告)号：US20050208078A1

公开(公告)日：2005-09-22

申请号：US11112358

申请日：2005-04-22

Applicant: Stephen Hoffman ,  Thomas Luke

Inventor： Stephen Hoffman ,  Thomas Luke

IPC: A61K39/015

CPC classification number: A61K39/015 ,  A61K2039/51 ,  A61K2039/523 ,  A61K2039/5256 ,  A61K2039/53 ,  A61K2039/54 ,  Y02A50/412

Abstract: The invention comprises a novel method for protecting subjects against malaria. The method of the invention involves inoculation with attenuated sporozoites, and in particular, but not limited to subcutaneous, intramuscular, intradermal, mucosal, submucosal, and cutaneous administration.

Abstract translation: 本发明包括一种保护受试者免受疟疾的新方法。 本发明的方法包括接种减毒的子孢子，特别是但不限于皮下，肌内，皮内，粘膜，粘膜下和皮肤给药。

公开(公告)号：US20060052980A1

公开(公告)日：2006-03-09

申请号：US10934839

申请日：2004-09-03

Applicant: Gary LaFollette ,  Carey Howard ,  Eric Ruud ,  Jon Ketelsen ,  Phyllis Vaughn ,  Thomas Luke ,  James Havers ,  Richard Desrochers ,  John Smith ,  Douglas Roberts

Inventor： Gary LaFollette ,  Carey Howard ,  Eric Ruud ,  Jon Ketelsen ,  Phyllis Vaughn ,  Thomas Luke ,  James Havers ,  Richard Desrochers ,  John Smith ,  Douglas Roberts

IPC: G01G19/14

CPC classification number: G01G19/02

Abstract: A remotely attended scale system for providing certified weighing services for a vehicle. The system having a plurality of weigh sites located remotely from one another and a weighmaster located at a central location. The weighmaster verifies proper placement of the vehicle upon the scale, may facilitate a normal weighing process, and may interact with the driver before issuing a certificate of weight. The method of the present invention includes steps of initiating a weigh cycle, delegating a weighmaster located at a central location for the weigh cycle, establishing communication between a driver and the weighmaster, weighing the vehicle, downloading weight information to the central location, and dispensing a certificate of weight at the weigh site.

Abstract translation: 一种用于为车辆提供认证称重服务的远程参与规模系统。 该系统具有彼此远离的多个称重站和位于中心位置的称重站。 称重师验证车辆在秤上的正确位置，可以促进正常的称重过程，并且可以在发出重量证书之前与驾驶员进行交互。 本发明的方法包括启动称重周期的步骤，委托位于权重周期的中心位置的衡器，建立驾驶员和称重师之间的通信，称重车辆，将重量信息下载到中心位置，以及分配 称重地点的重量证书。

公开(公告)号：US07432456B2

公开(公告)日：2008-10-07

申请号：US10934839

申请日：2004-09-03

Applicant: Gary D. LaFollette ,  Carey W. Howard ,  Eric J. Ruud ,  Jon R. Ketelsen ,  Phyllis J. Vaughn ,  Thomas Luke ,  James Havers ,  Richard Desrochers ,  John Smith ,  Douglas Roberts

Inventor： Gary D. LaFollette ,  Carey W. Howard ,  Eric J. Ruud ,  Jon R. Ketelsen ,  Phyllis J. Vaughn ,  Thomas Luke ,  James Havers ,  Richard Desrochers ,  John Smith ,  Douglas Roberts

IPC: G01G19/02

CPC classification number: G01G19/02

Abstract: A remotely attended scale system for providing certified weighing services for a vehicle. The system having a plurality of weigh sites located remotely from one another and a weighmaster located at a central location. The weighmaster verifies proper placement of the vehicle upon the scale, may facilitate a normal weighing process, and may interact with the driver before issuing a certificate of weight. The method of the present invention includes steps of initiating a weigh cycle, delegating a weighmaster located at a central location for the weigh cycle, establishing communication between a driver and the weighmaster, weighing the vehicle, downloading weight information to the central location, and dispensing a certificate of weight at the weigh site.

Abstract translation: 一种用于为车辆提供认证称重服务的远程参与规模系统。 该系统具有彼此远离的多个称重站和位于中心位置的称重站。 称重师验证车辆在秤上的正确位置，可以促进正常的称重过程，并且可以在发出重量证书之前与驾驶员进行交互。 本发明的方法包括启动称重周期的步骤，委托位于权重周期的中心位置的衡器，建立驾驶员和称重师之间的通信，称重车辆，将重量信息下载到中心位置，以及分配 称重地点的重量证书。