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公开(公告)号：US20120101571A1
公开(公告)日：2012-04-26
申请号：US13130180
申请日：2009-11-20
IPC分类号： A61F2/24
CPC分类号： A61B17/0057 , A61B2017/00575 , A61B2017/0061 , A61F2/2418 , A61F2/2436 , A61F2/2457 , A61F2002/8486 , A61F2220/0008 , A61F2220/0016 , A61F2230/0054 , A61F2230/0078 , A61F2230/008 , A61F2250/006
摘要： A heart valve prosthesis (100) comprises a housing component (110) and a valve component (130). The housing component (110) comprises a housing body (111) having a housing passage (112) extending therethrough. The housing body (111) is configured to be located in, or adjacent to and communicating with, a native valve orifice (16) of a heart (10) and to engage structure of the heart (10) to fix the housing body (111) in relation to the valve orifice (161). The housing component (111) is collapsible for delivery via catheter (2). The valve component (130) comprises a valve body (131) having a valve passage (132) extending therethrough. The valve body (131) is configured to be fixed within the housing passage (112) with the valve passage (132) extending along the housing passage (112). One or more flexible valve elements (131) is/are secured to the valve body and extend across the valve passage (132) for blocking blood flow in a first direction through the valve passage (132) whilst allowing blood flow in the opposing direction. The valve component (130) is collapsible for delivery via catheter (2) separate to the housing component (110). An associated method of replacing a failed or failing heart valve utilising the heart valve prosthesis (100) is also disclosed.
摘要翻译： 心脏瓣膜假体（100）包括壳体部件（110）和阀部件（130）。 壳体部件（110）包括具有延伸穿过其的壳体通道（112）的壳体（111）。 壳体（111）构造成位于心脏（10）的天然瓣膜（16）中或邻近并连通，并与心脏（10）的结构接合以固定壳体（111） ）相对于阀孔（161）。 壳体部件（111）可折叠以便经由导管（2）输送。 阀部件（130）包括具有延伸穿过其中的阀通道（132）的阀体（131）。 阀体（131）构造成固定在壳体通道（112）内，阀通道（132）沿壳体通道（112）延伸。 一个或多个柔性阀元件（131）被固定到阀体并延伸穿过阀通道（132），用于阻止通过阀通道（132）的第一方向的血流，同时允许血液沿相反方向流动。 阀部件（130）可折叠以便通过分离到壳体部件（110）的导管（2）输送。 还公开了利用心脏瓣膜假体（100）代替故障或故障心脏瓣膜的相关方法。
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公开(公告)号：US20080243245A1
公开(公告)日：2008-10-02
申请号：US10598716
申请日：2005-03-11
IPC分类号： A61F2/24
CPC分类号： A61F2/2427 , A61F2/2409 , A61F2/2418 , A61F2/2436 , A61F2/2487 , A61F2002/8486 , A61F2220/0016 , A61F2220/0058 , A61F2220/0075 , A61F2230/005 , A61F2230/0054 , A61F2230/0067
摘要： A percutaneous heart valve prosthesis (1) has a valve body (2) with a passage (9) extending between the first and second ends (7, 8) of the valve body (2). The valve body (2) is collapsible about a longitudinal axis (10) of the passage (9) for delivery of the valve body (2) via a catheter (18). One or more flexible valve leaflets (3, 4) are secured to the valve body (2) and extend across the passage (9) for blocking bloodflow in one direction through the passage (9). An anchor device (5), which is also collapsible for delivery via catheter (18), is secured to the valve body (2) by way of an anchor line (6). A failed or failing mitral heart valve (101) is treated by percutaneously locating the valve body (2) in the mitral valve orifice (102) with the anchor device (5) located in the right atrium (107) and engaging the inter-atrial septum (103), such that the taught anchor line (6) acts to secure the valve body (2) within the mitral valve orifice (102).
摘要翻译： 经皮心脏瓣膜假体（1）具有在阀体（2）的第一和第二端（7,8）之间延伸的通道（9）的阀体（2）。 阀体（2）围绕通道（9）的纵向轴线（10）可折叠，用于经由导管（18）输送阀体（2）。 一个或多个柔性瓣叶（3,4）固定到阀体（2）上，并延伸穿过通道（9），以阻止通过通道（9）的一个方向的血流。 还可以通过导管（18）进行输送的锚定装置（5）通过锚定线（6）固定到阀体（2）。 通过将锚定装置（5）定位在右心房（107）中并经由心室内（II）经心脏定位于二尖瓣孔（102）中的阀体（2）来治疗失败或失败的二尖瓣心脏瓣膜（101） 隔膜（103），使得教导的锚线（6）用于将阀体（2）固定在二尖瓣孔口（102）内。
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公开(公告)号：US08979922B2
公开(公告)日：2015-03-17
申请号：US10598716
申请日：2005-03-11
CPC分类号： A61F2/2427 , A61F2/2409 , A61F2/2418 , A61F2/2436 , A61F2/2487 , A61F2002/8486 , A61F2220/0016 , A61F2220/0058 , A61F2220/0075 , A61F2230/005 , A61F2230/0054 , A61F2230/0067
摘要： A percutaneous heart valve prosthesis (1) has a valve body (2) with a passage (9) extending between the first and second ends (7, 8) of the valve body (2). The valve body (2) is collapsible about a longitudinal axis (10) of the passage (9) for delivery of the valve body (2) via a catheter (18). One or more flexible valve leaflets (3, 4) are secured to the valve body (2) and extend across the passage (9) for blocking bloodflow in one direction through the passage (9). An anchor device (5), which is also collapsible for delivery via catheter (18), is secured to the valve body (2) by way of an anchor line (6). A failed or failing mitral heart valve (101) is treated by percutaneously locating the valve body (2) in the mitral valve orifice (102) with the anchor device (5) located in the right atrium (107) and engaging the inter-atrial septum (103), such that the taught anchor line (6) acts to secure the valve body (2) within the mitral valve orifice (102).
摘要翻译： 经皮心脏瓣膜假体（1）具有在阀体（2）的第一和第二端（7,8）之间延伸的通道（9）的阀体（2）。 阀体（2）围绕通道（9）的纵向轴线（10）可折叠，用于经由导管（18）输送阀体（2）。 一个或多个柔性瓣叶（3,4）固定到阀体（2）上，并延伸穿过通道（9），以阻止通过通道（9）的一个方向的血流。 还可以通过导管（18）进行输送的锚定装置（5）通过锚定线（6）固定到阀体（2）。 通过将锚固装置（5）定位在右心房（107）中并经由心室内（102）经由皮瓣将瓣膜体（2）定位在二尖瓣孔（102）中来治疗失败或失败的二尖瓣心脏瓣膜（101） 隔膜（103），使得教导的锚线（6）用于将阀体（2）固定在二尖瓣孔口（102）内。
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公开(公告)号：US10166014B2
公开(公告)日：2019-01-01
申请号：US13130180
申请日：2009-11-20
摘要： A heart valve prosthesis (100) comprises a housing component (110) and a valve component (130). The housing component (110) comprises a housing body (111) having a housing passage (112) extending therethrough. The housing body (111) is configured to be located in, or adjacent to and communicating with, a native valve orifice (16) of a heart (10) and to engage structure of the heart (10) to fix the housing body (111) in relation to the valve orifice (161). The housing component (111) is collapsible for delivery via catheter (2). The valve component (130) comprises a valve body (131) having a valve passage (132) extending therethrough. The valve body (131) is configured to be fixed within the housing passage (112) with the valve passage (132) extending along the housing passage (112). One or more flexible valve elements (131) is/are secured to the valve body and extend across the valve passage (132) for blocking blood flow in a first direction through the valve passage (132) whilst allowing blood flow in the opposing direction. The valve component (130) is collapsible for delivery via catheter (2) separate to the housing component (110). An associated method of replacing a failed or failing heart valve utilising the heart valve prosthesis (100) is also disclosed.
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