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公开(公告)号：US20180196055A1
公开(公告)日：2018-07-12
申请号：US15851513
申请日：2017-12-21
IPC分类号： G01N33/574 , C07K16/28
摘要： Provided herein are PD-L1 antibodies and methods for using the same for detecting human PD-L1 protein in biological samples. The PD-L1 antibodies and methods may be useful for diagnosing a medical condition associated with elevated PD-L1 levels (e.g., cancer) in subjects in need thereof and in evaluating the efficacy of a particular therapeutic regime in a subject diagnosed as having a PD-L1-related medical condition, among other uses.
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公开(公告)号：US20170073416A1
公开(公告)日：2017-03-16
申请号：US15363992
申请日：2016-11-29
IPC分类号： C07K16/28 , G01N33/574
CPC分类号： C07K16/2827 , C07K2317/14 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/565 , C07K2317/92 , G01N33/57407 , G01N33/57423 , G01N33/57438 , G01N33/57492 , G01N2333/70532
摘要： Provided herein are B7-H3 antibodies, fragments of such antibodies, and compositions comprising the same. The antibodies, antibody fragments and compositions are useful in a number of analytical methods, including immunohistochemical and immunocytochemical detection and analysis of B7-H3. Also provided herein are isolated peptides, compositions, and fusion proteins containing immunogenic determinants for said B7-H3 antibodies, animals immunized with the peptides and fusion proteins, isolated B cells obtained from the animals, and hybridomas made from the isolated B cells.
摘要翻译： 本文提供了B7-H3抗体，这种抗体的片段和包含其的组合物。 抗体，抗体片段和组合物可用于许多分析方法，包括B7-H3的免疫组织化学和免疫细胞化学检测和分析。 本文还提供了分离的肽，组合物和融合蛋白，其含有所述B7-H3抗体的免疫原性决定簇，用肽和融合蛋白免疫的动物，从动物获得的分离的B细胞，以及由分离的B细胞制成的杂交瘤。
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公开(公告)号：US20180208655A1
公开(公告)日：2018-07-26
申请号：US15920367
申请日：2018-03-13
IPC分类号： C07K16/28 , C07K16/30 , G01N33/68 , G01N33/574
CPC分类号： C07K16/28 , C07K16/30 , C07K2317/20 , G01N33/57411 , G01N33/57423 , G01N33/6893 , G01N2333/705
摘要： The present application discloses anti-GPNMB antibodies and methods of using the same. The antibodies are selected to bind to an epitope located in a C-terminal fragment of the protein and are selected for specificity in immunohistochemical assays. The antibodies are useful in, for example, immunohistochemical methods of detecting GPNMB-positive cells in tumors.
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公开(公告)号：US20170146535A1
公开(公告)日：2017-05-25
申请号：US15363832
申请日：2016-11-29
IPC分类号： G01N33/573 , G01N33/574 , C12N9/96 , C07K16/40 , C12N9/02
CPC分类号： G01N33/573 , C07K16/40 , C07K2317/14 , C07K2317/20 , C07K2317/34 , C07K2317/56 , C07K2317/567 , C12N9/0069 , C12N9/96 , C12Y113/11052 , G01N33/57496 , G01N2333/90241
摘要： The invention provides antibodies that bind specifically to human indoleamine 2,3-dioxygenase 1 (IDO1), and methods of using the same. The antibodies are capable of binding to a sequence comprising SEQ ID NO: 1 and specifically bind to human IDO1 in formalin fixed paraffin embedded tissues. The antibodies are useful in a number of different analytical techniques, including immunohistochemistry (IHC) and immunocytochemistry (ICC).
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公开(公告)号：US20200048353A1
公开(公告)日：2020-02-13
申请号：US16665359
申请日：2019-10-28
IPC分类号： C07K16/28 , G01N33/574
摘要： Provided herein are B7-H3 antibodies, fragments of such antibodies, and compositions comprising the same. The antibodies, antibody fragments and compositions are useful in a number of analytical methods, including immunohistochemical and immunocytochemical detection and analysis of B7-H3. Also provided herein are isolated peptides and fusion proteins containing immunogenic determinants for said B7-H3 antibodies, animals immunized with the peptides and fusion proteins, isolated B cells obtained from the animals, and hybridomas made from the isolated B cells.
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公开(公告)号：US20190376973A1
公开(公告)日：2019-12-12
申请号：US16548756
申请日：2019-08-22
IPC分类号： G01N33/573 , G01N33/574 , C12N9/96 , C12N9/02 , C07K16/40
摘要： The invention provides antibodies that bind specifically to human indoleamine 2,3-dioxygenase 1 (IDO1), nucleic acids encoding the same, and methods of using the same. The antibodies are capable of binding to a sequence comprising SEQ ID NO: 1 and specifically bind to human IDO1 in formalin fixed paraffin embedded tissues. The antibodies are useful in a number of different analytical techniques, including immunohistochemistry (IHC) and immunocytochemistry (ICC).
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7.发明申请公开(公告)号：US20180196057A1
公开(公告)日：2018-07-12
申请号：US15851502
申请日：2017-12-21
发明人： Fernando Jose Rebelo do Couto , Zhiming Liao , Andrea Muranyi , Kandavel Shanmugam , Shalini Singh , Yifei Zhu
IPC分类号： G01N33/574 , C07K16/22 , C07K16/30
CPC分类号： G01N33/57496 , C07K16/22 , C07K16/30 , C07K2317/20 , C07K2317/34 , C07K2317/92 , G01N2333/485
摘要： The invention provides anti-human pro-epiregulin and anti-human amphiregulin antibodies and methods of using the same. Anti-EREG antibodies raised against amino acids 148-169 and 156-169 of the human EREG protein, and anti-AREG antibodies raised against amino acids 238-252 of the human AREG protein are disclosed. Methods of using these antibodies to detect EREG and AREG and kits and other products for performing such methods are also disclosed.
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公开(公告)号：US09885721B2
公开(公告)日：2018-02-06
申请号：US14725953
申请日：2015-05-29
IPC分类号： C07K16/28 , C07K16/30 , G01N33/574
CPC分类号： G01N33/57492 , C07K16/2827 , C07K16/2896 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/92 , G01N2333/70596
摘要： Provided herein are PD-L1 antibodies and methods for using the same for diagnosing a medical condition associated with elevated PD-L1 levels (e.g., cancer) in subjects in need thereof and antigen binding fragments thereof. The PD-L1 antibodies and antigen binding fragments are also useful in evaluating the efficacy of a particular therapeutic regime in a subject diagnosed as having a PD-L1-related medical condition.
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公开(公告)号：US20180031566A1
公开(公告)日：2018-02-01
申请号：US15782804
申请日：2017-10-12
IPC分类号： G01N33/574 , C07K16/28
CPC分类号： G01N33/57492 , C07K16/28 , C07K16/30 , C07K2317/565 , C07K2317/567 , G01N1/30
摘要： Antibodies, compositions, systems, and methods for detecting C4.4a, for example immunohistochemistry methods for detecting C4.4a using a C4.4a antibody. The antibody may be obtained by immunizing a host with a C4.4a protein such as a peptide downstream of the signal peptide. The antibodies may be adapted to detect the uPAR-like domain 1 and uPAR-like domain 2. Also featured are methods for diagnosing C4.4a-associated tumors using C4.4a antibodies disclosed herein.
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公开(公告)号：US11002738B2
公开(公告)日：2021-05-11
申请号：US15920367
申请日：2018-03-13
IPC分类号： G01N33/574 , C07K16/30 , C07K16/28 , G01N33/68
摘要： The present application discloses anti-GPNMB antibodies and methods of using the same. The antibodies are selected to bind to an epitope located in a C-terminal fragment of the protein and are selected for specificity in immunohistochemical assays. The antibodies are useful in, for example, immunohistochemical methods of detecting GPNMB-positive cells in tumors.
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