公开(公告)号：US20230312555A1

公开(公告)日：2023-10-05

申请号：US18306515

申请日：2023-04-25

Applicant: Southwest Research Institute

Inventor： Shawn T. BLUMBERG ,  Paul W. MIGUEL ,  Daniel A. HINOJOSA

IPC: C07D451/10

CPC classification number: C07D451/10

Abstract: A synthetic route to scopolamine and/or atropine. In such context, the present invention identifies a method for preparing 6,7-dehydro atropine, which can be converted into either scopolamine and/or atropine, along with a method for converting a protected pyrrole into a tetrachlorobicylic compound, such as benzyl 3-oxo-8-azabicyclo[3.2.1]oct-6-ene-8-carboxylate.

公开(公告)号：US20230242487A1

公开(公告)日：2023-08-03

申请号：US17649581

申请日：2022-02-01

Applicant: Southwest Research Institute

Inventor： Shawn T. BLUMBERG ,  Antonio MENCHACA ,  Christopher DORSEY ,  Asa WATERMAN

IPC: C07D213/81

CPC classification number: C07D213/81

Abstract: Purification of bis-quaternary pyridinium oximes (BQPO) which may serve as organophosphorus nerve agent antidotes.

公开(公告)号：US20230121306A1

公开(公告)日：2023-04-20

申请号：US17450254

申请日：2021-10-07

Applicant: Southwest Research Institute

Inventor： Shawn T. BLUMBERG ,  Paul W. MIGUEL ,  Daniel A. HINOJOSA

IPC: C07D451/10

Abstract: A synthetic route to scopolamine and/or atropine. In such context, the present invention identifies a method for preparing 6,7-dehydro atropine, which can be converted into either scopolamine and/or atropine, along with a method for converting a protected pyrrole into a tetrachlorobicylic compound, such as benzyl 3-oxo-8-azabicyclo[3.2.1]oct-6-ene-8-carboxylate.

公开(公告)号：US20210138359A1

公开(公告)日：2021-05-13

申请号：US16949666

申请日：2020-11-10

Applicant: Southwest Research Institute

Inventor： Shawn T. BLUMBERG ,  Paul W. MIGUEL

IPC: B01D9/00 ,  C07D213/81 ,  C07C309/04

Abstract: The present invention is directed at the synthesis and characterization of recrystallized HI-6 dimethylsulfate (DMS). The method can comprise dissolving HI-6 DMS in an alkyl-based glycol and adding an antisolvent to recrystallize HI-6 DMS or dissolving HI-6 DMS in methanol and adding dimethoxy ethane or dimethyl formamide as the antisolvent to recrystallize HI-6 DMS. The recrystallized HI-6 DMS indicates a resistance to moisture absorption and/or a DSC melting point onset (MP Onset) at least at or above 160.0° C.