公开(公告)号：US20180059117A1

公开(公告)日：2018-03-01

申请号：US15799969

申请日：2017-10-31

Applicant: Sirigen Inc.

Inventor： Brent S. Gaylord ,  Janice W. Hong ,  Tsu-Ju Fu ,  ChengJun Sun ,  Russell A. Baldocchi

IPC: G01N33/58 ,  C08G61/12 ,  G01N33/542

CPC classification number: G01N33/582 ,  C08G61/02 ,  C08G61/12 ,  C08G2261/3142 ,  C08G2261/3221 ,  C08G2261/3241 ,  C08G2261/3246 ,  C08G2261/522 ,  C08G2261/78 ,  C08G2261/94 ,  G01N33/542 ,  H01L51/0039 ,  Y10T436/13

Abstract: Methods and compositions are provided that include a multichromophore and/or multichromophore complex for identifying a target biomolecule. A sensor biomolecule, for example, an antibody can be covalently linked to the multichromophore. Additionally, a signaling chromophore can be covalently linked to the multichromophore. The arrangement is such that the signaling chromophore is capable of receiving energy from the multichromophore upon excitation of the multichromophore. Since the sensor biomolecule is capable of interacting with the target biomolecule, the multichromophore and/or multichromophore complex can provide enhanced detection signals for a target biomolecule.

公开(公告)号：US09383353B2

公开(公告)日：2016-07-05

申请号：US14307258

申请日：2014-06-17

Applicant: Sirigen Inc.

Inventor： Brent S. Gaylord ,  Janice W. Hong ,  Tsu-Ju Fu ,  ChengJun Sun ,  Russell Baldocchi

IPC: G01N33/533 ,  G01N21/76 ,  G01N33/53 ,  G01N33/542 ,  G01N33/58 ,  C08G61/02 ,  H01L51/00

CPC classification number: G01N33/582 ,  C08G61/02 ,  C08G61/12 ,  C08G61/128 ,  C08G2261/3142 ,  C08G2261/3221 ,  C08G2261/3241 ,  C08G2261/3246 ,  C08G2261/522 ,  C08G2261/78 ,  C08G2261/94 ,  G01N33/542 ,  H01L51/0039 ,  Y10T436/13

Abstract: Methods and compositions are provided that include a multichromophore and/or multichromophore complex for identifying a target biomolecule. A sensor biomolecule, for example, an antibody can be covalently linked to the multichromophore. Additionally, a signaling chromophore can be covalently linked to the multichromophore. The arrangement is such that the signaling chromophore is capable of receiving energy from the multichromophore upon excitation of the multichromophore. Since the sensor biomolecule is capable of interacting with the target biomolecule, the multichromophore and/or multichromophore complex can provide enhanced detection signals for a target biomolecule.

公开(公告)号：US10859578B2

公开(公告)日：2020-12-08

申请号：US16154541

申请日：2018-10-08

Applicant: Sirigen Inc.

Inventor： Brent S. Gaylord ,  Janice W. Hong ,  Tsu-Ju Fu ,  ChengJun Sun ,  Russell A. Baldocchi

IPC: C08G61/12 ,  G01N33/58 ,  G01N33/542 ,  C08G61/02 ,  H01L51/00

Abstract: Methods and compositions are provided that include a multichromophore and/or multichromophore complex for identifying a target biomolecule. A sensor biomolecule, for example, an antibody can be covalently linked to the multichromophore. Additionally, a signaling chromophore can be covalently linked to the multichromophore. The arrangement is such that the signaling chromophore is capable of receiving energy from the multichromophore upon excitation of the multichromophore. Since the sensor biomolecule is capable of interacting with the target biomolecule, the multichromophore and/or multichromophore complex can provide enhanced detection signals for a target biomolecule.

公开(公告)号：US10107818B2

公开(公告)日：2018-10-23

申请号：US15364138

申请日：2016-11-29

Applicant: Sirigen Inc.

Inventor： Brent S. Gaylord ,  Janice W. Hong ,  Tsu-Ju Fu ,  ChengJun Sun ,  Russell A. Baldocchi

IPC: G01N33/58 ,  G01N33/542 ,  C08G61/12 ,  C08G61/02 ,  H01L51/00

Abstract: Methods and compositions are provided that include a multichromophore and/or multichromophore complex for identifying a target biomolecule. A sensor biomolecule, for example, an antibody can be covalently linked to the multichromophore. Additionally, a signaling chromophore can be covalently linked to the multichromophore. The arrangement is such that the signaling chromophore is capable of receiving energy from the multichromophore upon excitation of the multichromophore. Since the sensor biomolecule is capable of interacting with the target biomolecule, the multichromophore and/or multichromophore complex can provide enhanced detection signals for a target biomolecule.

公开(公告)号：US20190033317A1

公开(公告)日：2019-01-31

申请号：US16154541

申请日：2018-10-08

Applicant: Sirigen Inc.

Inventor： Brent S. Gaylord ,  Janice W. Hong ,  Tsu-Ju Fu ,  ChengJun Sun ,  Russell A. Baldocchi

IPC: G01N33/58 ,  C08G61/12

Abstract: Methods and compositions are provided that include a multichromophore and/or multichromophore complex for identifying a target biomolecule. A sensor biomolecule, for example, an antibody can be covalently linked to the multichromophore. Additionally, a signaling chromophore can be covalently linked to the multichromophore. The arrangement is such that the signaling chromophore is capable of receiving energy from the multichromophore upon excitation of the multichromophore. Since the sensor biomolecule is capable of interacting with the target biomolecule, the multichromophore and/or multichromophore complex can provide enhanced detection signals for a target biomolecule.

公开(公告)号：US10126302B2

公开(公告)日：2018-11-13

申请号：US15162436

申请日：2016-05-23

Applicant: Sirigen Inc.

Inventor： Brent S. Gaylord ,  Janice W. Hong ,  Tsu-Ju Fu ,  ChengJun Sun ,  Russell A. Baldocchi

IPC: C08G61/12 ,  G01N33/58 ,  G01N33/542 ,  C08G61/02 ,  H01L51/00

Abstract: Methods and compositions are provided that include a multichromophore and/or multichromophore complex for identifying a target biomolecule. A sensor biomolecule, for example, an antibody can be covalently linked to the multichromophore. Additionally, a signaling chromophore can be covalently linked to the multichromophore. The arrangement is such that the signaling chromophore is capable of receiving energy from the multichromophore upon excitation of the multichromophore. Since the sensor biomolecule is capable of interacting with the target biomolecule, the multichromophore and/or multichromophore complex can provide enhanced detection signals for a target biomolecule.

公开(公告)号：US20170115298A1

公开(公告)日：2017-04-27

申请号：US15364138

申请日：2016-11-29

Applicant: Sirigen Inc.

Inventor： Brent S. Gaylord ,  Janice W. Hong ,  Tsu-Ju Fu ,  ChengJun Sun ,  Russell A. Baldocchi

IPC: G01N33/58 ,  C08G61/12 ,  G01N33/542

CPC classification number: G01N33/582 ,  C08G61/02 ,  C08G61/12 ,  C08G61/128 ,  C08G2261/3142 ,  C08G2261/3221 ,  C08G2261/3241 ,  C08G2261/3246 ,  C08G2261/522 ,  C08G2261/78 ,  C08G2261/94 ,  G01N33/542 ,  H01L51/0039 ,  Y10T436/13

Abstract: Methods and compositions are provided that include a multichromophore and/or multichromophore complex for identifying a target biomolecule. A sensor biomolecule, for example, an antibody can be covalently linked to the multichromophore. Additionally, a signaling chromophore can be covalently linked to the multichromophore. The arrangement is such that the signaling chromophore is capable of receiving energy from the multichromophore upon excitation of the multichromophore. Since the sensor biomolecule is capable of interacting with the target biomolecule, the multichromophore and/or multichromophore complex can provide enhanced detection signals for a target biomolecule.

公开(公告)号：US20160266132A1

公开(公告)日：2016-09-15

申请号：US15162436

申请日：2016-05-23

Applicant: Sirigen Inc.

Inventor： Brent S. Gaylord ,  Janice W. Hong ,  Tsu-Ju Fu ,  ChengJun Sun ,  Russell A. Baldocchi

IPC: G01N33/58 ,  C08G61/12 ,  G01N33/542

CPC classification number: G01N33/582 ,  C08G61/02 ,  C08G61/12 ,  C08G61/128 ,  C08G2261/3142 ,  C08G2261/3221 ,  C08G2261/3241 ,  C08G2261/3246 ,  C08G2261/522 ,  C08G2261/78 ,  C08G2261/94 ,  G01N33/542 ,  H01L51/0039 ,  Y10T436/13

Abstract: Methods and compositions are provided that include a multichromophore and/or multichromophore complex for identifying a target biomolecule. A sensor biomolecule, for example, an antibody can be covalently linked to the multichromophore. Additionally, a signaling chromophore can be covalently linked to the multichromophore. The arrangement is such that the signaling chromophore is capable of receiving energy from the multichromophore upon excitation of the multichromophore. Since the sensor biomolecule is capable of interacting with the target biomolecule, the multichromophore and/or multichromophore complex can provide enhanced detection signals for a target biomolecule.

Abstract translation: 提供了包括用于鉴定靶生物分子的多色素和/或多重色团合成物的方法和组合物。 传感器生物分子，例如抗体可以共价连接到多色素。 另外，信号发色团可以共价连接到多重色素。 这种布置使得信号发色团能够在多重色谱激发时能够从多重色淀中接收能量。 由于传感器生物分子能够与目标生物分子相互作用，多重色谱和/或多重色谱复合物可为目标生物分子提供增强的检测信号。