公开(公告)号：US11254705B2

公开(公告)日：2022-02-22

申请号：US16330049

申请日：2017-08-31

Applicant: Sirenas LLC

Inventor： Ippei Usui ,  Bryan Junn Lee ,  Steven Bruce Cohen ,  Venkat Rami Reddy Macherla ,  Jacob Neal Beverage ,  Chung-Mao Pan ,  Farhana Barmare ,  Eduardo Esquenazi

IPC: C07K11/02 ,  C07K7/06 ,  C07K16/32 ,  A61K47/68 ,  A61P35/00 ,  A61K38/08 ,  A61K38/00 ,  C07K16/00

Abstract: Provided are cyclic peptide analogs, conjugates comprising such compounds, and pharmaceutical compositions comprising such compounds and conjugates, and methods of treating cancer with such compounds and conjugates.

公开(公告)号：US12077606B2

公开(公告)日：2024-09-03

申请号：US17560105

申请日：2021-12-22

Applicant: Sirenas LLC

Inventor： Ippei Usui ,  Bryan Junn Lee ,  Steven Bruce Cohen ,  Venkat Rami Reddy Macherla ,  Jacob Neal Beverage ,  Chung-Mao Pan ,  Farhana Barmare ,  Eduardo Esquenazi

IPC: C07K11/02 ,  A61K38/08 ,  A61K47/68 ,  A61P35/00 ,  C07K7/06 ,  C07K16/32 ,  A61K38/00 ,  C07K16/00

CPC classification number: C07K7/06 ,  A61K38/08 ,  A61K47/6811 ,  A61K47/6855 ,  A61K47/6889 ,  A61P35/00 ,  C07K16/32 ,  A61K38/00 ,  C07K16/00 ,  C07K2319/00

Abstract: Provided are cyclic peptide analogs, conjugates comprising such compounds, and pharmaceutical compositions comprising such compounds and conjugates, and methods of treating cancer with such compounds and conjugates.

公开(公告)号：US10472395B2

公开(公告)日：2019-11-12

申请号：US15060479

申请日：2016-03-03

Applicant: Sirenas LLC

Inventor： Venkat Rami Reddy Macherla ,  Alexander Wayne Schammel ,  Ippei Usui ,  Elizabeth Paige Stout ,  Jacob Neal Beverage ,  Bryan Junn Lee ,  Steven Bruce Cohen

IPC: C07K11/02 ,  A61K38/15 ,  C07K16/32

Abstract: Provided are cyclic peptide analogs, conjugates comprising such compounds, and pharmaceutical compositions comprising such compounds and conjugates, and methods of treating cancer with such compounds and conjugates.