公开(公告)号：US20250027143A1

公开(公告)日：2025-01-23

申请号：US18889834

申请日：2024-09-19

Applicant: Singular Genomics Systems, Inc.

Inventor： Eli N. Glezer ,  Martin Maria Fabani ,  Ryan Shultzaberger ,  Bharat Sridhar ,  Gudrun Stengel ,  Christopher Jen-Yue Wei

IPC: C12Q1/6853 ,  C12Q1/6869

Abstract: Provided herein are methods of detecting polynucleotides with a set of barcoded oligonucleotide probes.

公开(公告)号：US11859244B2

公开(公告)日：2024-01-02

申请号：US18185786

申请日：2023-03-17

Applicant: Singular Genomics Systems, Inc

Inventor： Ryan Shultzaberger ,  Allen Lipson ,  Daan Witters

IPC: C12Q1/6874 ,  C12Q1/6876 ,  C12Q1/6855

CPC classification number: C12Q1/6855 ,  C12Q1/6874 ,  C12Q1/6876

Abstract: Disclosed herein, inter alia, are polynucleotides, supports, kits, and methods of use thereof for amplifying, immobilizing, and sequencing polynucleotides.

公开(公告)号：US20210277461A1

公开(公告)日：2021-09-09

申请号：US17194023

申请日：2021-03-05

Applicant: SINGULAR GENOMICS SYSTEMS, INC.

Inventor： Eli N. Glezer ,  Martin Maria Fabani ,  Timothy Looney ,  Sabrina Shore ,  Ryan Shultzaberger ,  Daan Witters

IPC: C12Q1/6869 ,  C12Q1/6855

Abstract: Provided herein are methods for sequencing both strands of a double stranded nucleic acid fragment that improves fidelity and accuracy of a sequence determination compared to traditional next generation sequencing methods. Compositions and kits for use in the methods are also provided.

公开(公告)号：US20240392369A1

公开(公告)日：2024-11-28

申请号：US18776983

申请日：2024-07-18

Applicant: Singular Genomics Systems, Inc.

Inventor： Daan Witters ,  Eli N. Glezer ,  Andrew King ,  Sabrina Shore ,  Ryan Shultzaberger

IPC: C12Q1/6874

Abstract: Disclosed herein, inter alia, are compositions and methods for amplification and sequencing of nucleic acids.

公开(公告)号：US11802307B2

公开(公告)日：2023-10-31

申请号：US18185783

申请日：2023-03-17

Applicant: Singular Genomics Systems, Inc

Inventor： Ryan Shultzaberger ,  Allen Lipson ,  Daan Witters

IPC: C12Q1/6855

CPC classification number: C12Q1/6855

Abstract: Disclosed herein, inter alia, are polynucleotides, supports, kits, and methods of use thereof for amplifying, immobilizing, and sequencing polynucleotides.

公开(公告)号：US12139754B2

公开(公告)日：2024-11-12

申请号：US17486656

申请日：2021-09-27

Applicant: Singular Genomics Systems, Inc.

Inventor： Eli N. Glezer ,  Martin Maria Fabani ,  Ryan Shultzaberger ,  Bharat Sridhar ,  Gudrun Stengel ,  Christopher Jen-Yue Wei

IPC: C12Q1/6853 ,  C12Q1/6869

Abstract: Provided herein are methods of making, amplifying, and sequencing tagged nucleic acid complements, compositions including interposing oligonucleotide barcodes, and kits useful in obtaining long-range sequence data.

公开(公告)号：US20220119878A1

公开(公告)日：2022-04-21

申请号：US17500759

申请日：2021-10-13

Applicant: SINGULAR GENOMICS SYSTEMS, INC.

Inventor： Eli N. Glezer ,  Martin Maria Fabani ,  Timothy Looney ,  Sabrina Shore ,  Ryan Shultzaberger ,  Daan Witters

IPC: C12Q1/6869 ,  C12Q1/6855

Abstract: Provided herein are methods for sequencing both strands of a double stranded nucleic acid fragment that improves fidelity and accuracy of a sequence determination compared to traditional next generation sequencing methods. Compositions and kits for use in the methods are also provided.

公开(公告)号：US11155858B2

公开(公告)日：2021-10-26

申请号：US17127514

申请日：2020-12-18

Applicant: Singular Genomics Systems, Inc.

Inventor： Eli N. Glezer ,  Martin Maria Fabani ,  Ryan Shultzaberger ,  Bharat Sridhar ,  Gudrun Stengel ,  Christopher Jen-Yue Wei

IPC: C12Q1/6853 ,  C12Q1/6869

Abstract: Provided herein are methods of making, amplifying, and sequencing tagged nucleic acid complements, compositions including interposing oligonucleotide barcodes, and kits useful in obtaining long-range sequence data.

公开(公告)号：US12123055B2

公开(公告)日：2024-10-22

申请号：US17727673

申请日：2022-04-22

Applicant: Singular Genomics Systems, Inc.

Inventor： Eli N. Glezer ,  Martin Maria Fabani ,  Timothy Looney ,  Sabrina Shore ,  Ryan Shultzaberger ,  Daan Witters

IPC: C12Q1/68 ,  C12Q1/6855 ,  C12Q1/6869

CPC classification number: C12Q1/6869 ,  C12Q1/6855

Abstract: Provided herein are methods for sequencing both strands of a double stranded nucleic acid fragment that improves fidelity and accuracy of a sequence determination compared to traditional next generation sequencing methods. Compositions and kits for use in the methods are also provided.

公开(公告)号：US12071665B2

公开(公告)日：2024-08-27

申请号：US18176616

申请日：2023-03-01

Applicant: Singular Genomics Systems, Inc.

Inventor： Daan Witters ,  Eli N. Glezer ,  Andrew King ,  Sabrina Shore ,  Ryan Shultzaberger

IPC: C12Q1/68 ,  C12Q1/6874

CPC classification number: C12Q1/6874

Abstract: Disclosed herein, inter alia, are compositions and methods for amplification of nucleic acid templates, including hybridizing a linear polynucleotide to an immobilized primer on a surface, circularizing the linear polynucleotide to form a circular polynucleotide, and extending the primer with a polymerase.