公开(公告)号：US20230212180A1

公开(公告)日：2023-07-06

申请号：US17926763

申请日：2021-06-11

Applicant: Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd.

Inventor： Lei Yi ,  Qiang Tian ,  Shoujun Chen ,  Liqiang Song ,  Taijin Wang ,  Qian Liu ,  Yong Ge ,  Yu Yang ,  Huiping Chen ,  Hongmei Song ,  Jingyi Wang

IPC: C07D491/107 ,  C07D401/14 ,  C07D471/10 ,  C07D491/20 ,  A61P35/00

CPC classification number: C07D491/107 ,  C07D401/14 ,  C07D471/10 ,  C07D491/20 ,  A61P35/00

Abstract: The present invention belongs to the field of pharmaceutical chemistry, and relates to a substituted pyrazine compound, a pharmaceutical composition comprising same, and the use thereof. In particular, the present invention relates to a compound with the structure of formula (I), which exhibits a good SHP2 inhibiting activity, and can act as an efficient SHP2 inhibitor for preventing and/or treating SHP2-related diseases.