公开(公告)号：US20240173421A1

公开(公告)日：2024-05-30

申请号：US18486027

申请日：2023-10-12

申请人： Seagen Inc.

发明人： Philip MOQUIST ,  Matthew R. LEVENGOOD ,  Christopher I. LEISKE ,  Noah A. BINDMAN

IPC分类号： A61K47/60 ,  A61K47/68 ,  A61P35/00 ,  C07K16/28

CPC分类号： A61K47/60 ,  A61K47/6849 ,  A61K47/6889 ,  A61P35/00 ,  C07K16/2878 ,  C07K2317/24 ,  C07K2317/72 ,  C07K2317/732

摘要： The present disclosure provides, inter alia, antibodies with covalently attached biocompatible polymeric moieties, that are useful in treating various diseases such as cancer and autoimmune disorders.

公开(公告)号：US20240033372A1

公开(公告)日：2024-02-01

申请号：US18054497

申请日：2022-11-10

申请人： Seagen Inc.

发明人： Matthew R. LEVENGOOD

IPC分类号： A61K47/68 ,  A61K47/61 ,  A61K47/60 ,  A61K31/4745 ,  A61K31/704 ,  A61K31/496

CPC分类号： A61K47/6889 ,  A61K47/61 ,  A61K47/6883 ,  A61K47/60 ,  A61K47/6803 ,  A61K31/496 ,  A61K47/6809 ,  A61K47/6849 ,  A61K31/4745 ,  A61K31/704 ,  A61K47/6817

摘要： The present disclosure provides, inter alia, multi-drug Antibody Drug Conjugates (MD-ADCs) and Linking Assembly (LA) Units that are constructed in a site-specific matter via “orthogonal” deprotection and drug loading. Also provided are, Protected Linking Assembly Units, which allow for ‘orthogonal’ deprotection and construction of MD-ADCs and LA Units of the present disclosure.