公开(公告)号：US20210353596A1

公开(公告)日：2021-11-18

申请号：US17388208

申请日：2021-07-29

Applicant: Scandion Oncology A/S

Inventor： Nils Aage Brünner ,  Palle Christophersen ,  Jan Stenvang ,  Jens Lichtenberg ,  Annemette Thougaard

IPC: A61K31/41 ,  A61P35/00 ,  A61K33/243 ,  A61K31/138 ,  A61K31/337 ,  A61K31/495 ,  A61K31/513 ,  A61K31/566 ,  A61K31/4745 ,  C07D257/04

Abstract: The present invention relates to treatment of cancer, in particular to methods of sensitising cancer cells to an anti-cancer therapy by administering an effective amount of a modulator of Volume Regulated Anion Channels, i.e. a VRAC modulator.

公开(公告)号：US11903927B2

公开(公告)日：2024-02-20

申请号：US17388208

申请日：2021-07-29

Applicant: Scandion Oncology A/S

Inventor： Nils Aage Brünner ,  Palle Christophersen ,  Jan Stenvang ,  Jens Lichtenberg ,  Annemette Thougaard

IPC: A61K31/41 ,  A61P35/00 ,  A61K33/243 ,  A61K31/138 ,  A61K31/337 ,  A61K31/495 ,  A61K31/513 ,  A61K31/566 ,  A61K31/4745 ,  C07D257/04

CPC classification number: A61K31/41 ,  A61K31/138 ,  A61K31/337 ,  A61K31/4745 ,  A61K31/495 ,  A61K31/513 ,  A61K31/566 ,  A61K33/243 ,  A61P35/00 ,  C07D257/04 ,  A61K31/41 ,  A61K2300/00 ,  A61K31/4745 ,  A61K2300/00

Abstract: The present invention relates to treatment of cancer, in particular to methods of sensitising cancer cells to an anti-cancer therapy by administering an effective amount of a modulator of Volume Regulated Anion Channels, i.e. a VRAC modulator.

公开(公告)号：US20210251963A1

公开(公告)日：2021-08-19

申请号：US17272808

申请日：2019-09-06

Applicant: Scandion Oncology A/S

Inventor： Nils Aage Brünner ,  Jan Stenvang

IPC: A61K31/41 ,  A61K31/573 ,  A61K31/565 ,  A61K31/138 ,  A61K45/06 ,  A61K31/4745 ,  A61K31/704 ,  A61K31/337 ,  A61P35/00

Abstract: The present invention relates to treatment of diseases characterized by elevated expression and/or activity of SRPK1 with specific SRPK1 inhibitors and to methods for identifying subjects who may benefit from such treatment.

公开(公告)号：US11103481B2

公开(公告)日：2021-08-31

申请号：US16302195

申请日：2017-05-17

Applicant: Scandion Oncology A/S

Inventor： Nils Aage Brünner ,  Palle Christophersen ,  Jan Stenvang ,  Jens Lichtenberg ,  Annemette Thougaard

IPC: A61K31/41 ,  A61P35/00 ,  A61K33/243 ,  A61K31/138 ,  A61K31/337 ,  A61K31/495 ,  A61K31/513 ,  A61K31/566 ,  A61K31/4745 ,  C07D257/04

Abstract: The present invention relates to treatment of cancer, in particular to methods of sensitising cancer cells to an anti-cancer therapy by administering an effective amount of a modulator of Volume Regulated Anion Channels, i.e. a VRAC modulator.