公开(公告)号：US11939367B2

公开(公告)日：2024-03-26

申请号：US17188912

申请日：2021-03-01

申请人： Sanford Burnham Prebys Medical Discovery Institute ,  PFIZER INC.

发明人： Carl F. Ware ,  John Sedy ,  Tigran Aivazian ,  Brian Miller ,  Natasha K. Crellin

IPC分类号： C07K14/705 ,  A61K38/17 ,  A61K45/06 ,  A61K47/68 ,  C07K14/71 ,  C07K14/715 ,  C07K19/00 ,  A61K38/00

CPC分类号： C07K14/71 ,  A61K38/17 ,  A61K38/177 ,  A61K38/1793 ,  A61K45/06 ,  A61K47/68 ,  C07K14/70578 ,  C07K14/70596 ,  C07K14/715 ,  C07K19/00 ,  A61K38/00 ,  C07K2319/30

摘要： The present invention is based on the seminal discovery that BTLA agonist fusion proteins modulate an immune response. Specifically, the present invention provides fusion proteins that bind BTLA enhancing BTLA signaling. The present invention further provides methods of treating cancer and immune and inflammatory diseases and disorders with a BTLA agonist fusion protein as described herein.

公开(公告)号：US20240247047A1

公开(公告)日：2024-07-25

申请号：US18442988

申请日：2024-02-15

申请人： Sanford Burnham Prebys Medical Discovery Institute ,  PFIZER INC.

发明人： Carl F. Ware ,  John Sedy ,  Tigran Aivazian ,  Brian Miller ,  Natasha K. Crellin

IPC分类号： C07K14/71 ,  A61K38/00 ,  A61K38/17 ,  A61K45/06 ,  A61K47/68 ,  C07K14/705 ,  C07K14/715 ,  C07K19/00

CPC分类号： C07K14/71 ,  A61K38/17 ,  A61K38/177 ,  A61K38/1793 ,  A61K45/06 ,  A61K47/68 ,  C07K14/70578 ,  C07K14/70596 ,  C07K14/715 ,  C07K19/00 ,  A61K38/00 ,  C07K2319/30

摘要： The present invention is based on the seminal discovery that BTLA agonist fusion proteins modulate an immune response. Specifically, the present invention provides fusion proteins that bind BTLA enhancing BTLA signaling. The present invention further provides methods of treating cancer and immune and inflammatory diseases and disorders with a BTLA agonist fusion protein as described herein.

公开(公告)号：US10961297B2

公开(公告)日：2021-03-30

申请号：US15737259

申请日：2016-06-29

申请人： Sanford Burnham Prebys Medical Discovery Institute ,  Pfizer Inc.

发明人： Carl F. Ware ,  John Sedy ,  Tigran Aivazian ,  Brian Miller ,  Natasha K. Crellin

IPC分类号： A61K38/17 ,  C07K14/715 ,  C07K14/71 ,  A61K45/06 ,  C07K14/705 ,  A61K38/00

摘要： The present invention is based on the seminal discovery that BTLA agonist fusion proteins modulate an immune response. Specifically, the present invention provides fusion proteins that bind BTLA enhancing BTLA signaling. The present invention further provides methods of treating cancer and immune and inflammatory diseases and disorders with a BTLA agonist fusion protein as described herein.

公开(公告)号：US11352428B2

公开(公告)日：2022-06-07

申请号：US15570013

申请日：2016-04-29

申请人： Sanford Burnham Prebys Medical Discovery Institute

发明人： Carl F. Ware ,  John Sedy ,  Paula Norris

IPC分类号： C07K16/28 ,  A61P37/00 ,  A61P29/00 ,  C07K14/715 ,  A61K39/00

摘要： The present invention relates to the seminal discovery that BTLA agonist antibodies modulate the immune system. Specifically, the present invention provides antibodies which bind BTLA in the activated state enhancing BTLA signaling. The present invention further provides methods of treating immune and inflammatory diseases and disorders with a BTLA agonist antibody.

公开(公告)号：US10759863B2

公开(公告)日：2020-09-01

申请号：US14916986

申请日：2014-09-04

申请人： Sanford Burnham Prebys Medical Discovery Institute

发明人： Carl F. Ware ,  John R. Sedy

IPC分类号： A61K31/7088 ,  A61K31/7105 ,  A61K38/20 ,  C12N15/113 ,  C07K16/28 ,  G01N33/50 ,  A61K45/06 ,  A61K31/00 ,  C07K14/54 ,  A61K39/00

摘要： The present invention relate to the discovery that BTLA, IL-7 and RORγt modulate the activity and expression of γδT cells. Specifically, the present invention provides methods of modulating γδT cell homeostasis and function by regulating expression of BTLA. The present invention further provides agents which modulate the activity and expression of BTLA, RORyt and IL-7 and methods for screening of such agents. The present invention also provides methods for treating autoimmune or inflammatory diseases using modulators of BTLA, RORyt and IL-7.

公开(公告)号：US20180170999A1

公开(公告)日：2018-06-21

申请号：US15737259

申请日：2016-06-29

申请人： Sanford-Burnham Medical Research Institute ,  PFIZER INC.

发明人： Carl F. Ware ,  John Sedy ,  Tigran Aivazian ,  Brian Miller ,  Natasha K. Crellin

IPC分类号： C07K14/71 ,  A61K38/17 ,  A61K45/06 ,  C07K14/705

CPC分类号： C07K14/71 ,  A61K38/00 ,  A61K38/17 ,  A61K45/06 ,  C07K14/70578 ,  C07K2319/30

摘要： The present invention is based on the seminal discovery that BTLA agonist fusion proteins modulate an immune response. Specifically, the present invention provides fusion proteins that bind BTLA enhancing BTLA signaling The present invention further provides methods of treating cancer and immune and inflammatory diseases and disorders with a BTLA agonist fusion protein as described herein.