公开(公告)号：US20160145686A1

公开(公告)日：2016-05-26

申请号：US14821104

申请日：2015-08-07

Applicant: Samsung Electronics Co., Ltd.

Inventor： Myoungsoon Kim ,  Youngsam Lee ,  Yongsub Kim ,  Hyuntae Kang

IPC: C12Q1/68

CPC classification number: C12Q1/6883 ,  C12N2310/20 ,  C12Q2600/158

Abstract: A biomarker for diagnosing senescence, a composition and a kit for diagnosing a senescence level to detect the same, a method of diagnosing a senescence level in a cell or subject, and a method of screening a senescence inhibitor.

Abstract translation: 用于诊断衰老的生物标志物，用于诊断衰老水平以检测其衰老的组合物和试剂盒，诊断细胞或受试者的衰老水平的方法以及筛选衰老抑制剂的方法。

公开(公告)号：US09988632B2

公开(公告)日：2018-06-05

申请号：US15378368

申请日：2016-12-14

Applicant: Samsung Electronics Co., Ltd.

Inventor： Hyojei Choi ,  Myoungsoon Kim ,  Youngsam Lee

IPC: C07H21/02 ,  C07H21/04 ,  C12N15/113 ,  A61K8/60 ,  A61Q19/00 ,  C12Q1/68

CPC classification number: C12N15/113 ,  A61K8/606 ,  A61Q19/08 ,  C12N2310/113 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2310/531 ,  C12Q1/6881 ,  C12Q2600/178

Abstract: Provided are a composition for stimulating DNA damage in cells, the composition including a p53 induced non-coding transcript (PINT) gene expression inhibitor or a PINT activity inhibitor, a method of killing senescent cells in a subject, and a method of monitoring DNA damage in cells.

公开(公告)号：US20160107141A1

公开(公告)日：2016-04-21

申请号：US14884548

申请日：2015-10-15

Applicant: Samsung Electronics Co., Ltd.

Inventor： Myoungsoon Kim ,  Gahee Kim ,  Youngwan Ha

IPC: B01J20/286 ,  G01N33/545 ,  B01J20/26

CPC classification number: B01J20/286 ,  B01J20/265 ,  G01N33/545

Abstract: A solid support with a polymer, and a method of using the solid support are provided.

Abstract translation: 提供了具有聚合物的固体支持物和使用固体支持物的方法。

公开(公告)号：US20180002703A1

公开(公告)日：2018-01-04

申请号：US15681262

申请日：2017-08-18

Applicant: Samsung Electronics Co., Ltd.

Inventor： Myoungsoon Kim ,  Yongsub Kim ,  Young-Sam Lee

IPC: C12N15/113

CPC classification number: C12N15/1138 ,  C12N15/113 ,  C12N2310/113 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2310/20 ,  C12N2310/531 ,  C12N2320/30

Abstract: Provided is a composition and method for reducing a cellular senescence level by inhibiting the activity or expression of one or more of DCUN1D3 protein or gene encoding same and a polynucleotide having a nucleotide sequence of SEQ ID NO: 5, as well as a method of treating a disease or a disease symptom associated with an increased cellular senescence level in a mammal.

公开(公告)号：US20170183656A1

公开(公告)日：2017-06-29

申请号：US15378368

申请日：2016-12-14

Applicant: Samsung Electronics Co., Ltd.

Inventor： Hyojei Choi ,  Myoungsoon Kim ,  Youngsam Lee

IPC: C12N15/113 ,  A61K8/60 ,  A61Q19/00 ,  C12Q1/68

CPC classification number: C12N15/113 ,  A61K8/606 ,  A61Q19/08 ,  C12N2310/113 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2310/531 ,  C12Q1/6881 ,  C12Q2600/178

Abstract: Provided are a composition for stimulating DNA damage in cells, the composition including a p53 induced non-coding transcript (PINT) gene expression inhibitor or a PINT activity inhibitor, a method of killing senescent cells in a subject, and a method of monitoring DNA damage in cells.

公开(公告)号：US10329569B2

公开(公告)日：2019-06-25

申请号：US15681262

申请日：2017-08-18

Applicant: Samsung Electronics Co., Ltd.

Inventor： Myoungsoon Kim ,  Yongsub Kim ,  Young-Sam Lee

IPC: C12N15/11 ,  C07H21/02 ,  C07H21/04 ,  C12N15/113

Abstract: Provided is a composition and method for reducing a cellular senescence level by inhibiting the activity or expression of one or more of DCUN1D3 protein or gene encoding same and a polynucleotide having a nucleotide sequence of SEQ ID NO: 5, as well as a method of treating a disease or a disease symptom associated with an increased cellular senescence level in a mammal.

公开(公告)号：US20170002362A1

公开(公告)日：2017-01-05

申请号：US15200937

申请日：2016-07-01

Applicant: Samsung Electronics Co., Ltd.

Inventor： Myoungsoon Kim ,  Yongsub Kim ,  Young-Sam Lee

IPC: C12N15/113

CPC classification number: C12N15/1138 ,  C12N15/113 ,  C12N2310/113 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2310/20 ,  C12N2310/531 ,  C12N2320/30

Abstract: Provided is a composition and method for reducing a cellular senescence level by inhibiting the activity or expression of one or more of DCUN1D3 protein or gene encoding same and a polynucleotide having a nucleotide sequence of SEQ ID NO: 5, as well as a method of treating a disease or a disease symptom associated with an increased cellular senescence level in a mammal.

Abstract translation: 提供了通过抑制DCUN1D3蛋白或编码其的基因的一种或多种的活性或表达以及具有SEQ ID NO：5的核苷酸序列的多核苷酸来降低细胞衰老水平的组合物和方法，以及治疗 与哺乳动物中增加的细胞衰老水平相关的疾病或疾病症状。