公开(公告)号：US20210210166A1

公开(公告)日：2021-07-08

申请号：US17143780

申请日：2021-01-07

Applicant: Samsung Electronics Co., Ltd.

Inventor： Rajasekhara Reddy DUVVURU MUNI ,  Tadi Venkata SIVA KUMAR ,  Taeyong KIM ,  Garima AGARWAL ,  Priyadarshini Panemangalore PAI

IPC: G16B30/10 ,  G16B40/00

Abstract: Embodiments herein disclose a method for identifying co-evolving sites and and at least one substituent amino acid residue. The method includes obtaining a current state of a protein and an ancestral state of the protein. Further, the method includes determining at least one amino acid substitution along with at least one co-evolving site associated with the protein based on the current state of the protein and the ancestral state of the protein. Further, the method includes assessing the at least one amino acid substitution as a function of a nucleotide substitution in the protein. Further, the method includes assessing at least one co-evolving site substitution based on the at least one assessed amino acid substitution. Further, the method includes identifying the co-evolving sites and at least one substituent amino acid residue.

公开(公告)号：US20170046478A1

公开(公告)日：2017-02-16

申请号：US15159546

申请日：2016-05-19

Applicant: Samsung Electronics Co., Ltd.

Inventor： Garima AGARWAL ,  Srikanth Rama MALLAVARAPU ,  Ajit Shyamsunder BOPARDIKAR ,  Taejin AHN

IPC: G06F19/22 ,  G06N5/02 ,  G06F19/00 ,  G06F17/30

Abstract: Provided are methods and devices for mutation prioritization, which are helpful in personalized therapy of a patient. Also, provided are methods and devices for generating a disease knowledgebase. Information present in various categories of knowledge sources with respect to a particular association of set may be identified. The identified information is ranked with respect to the disease knowledgebase to find out the most relevant ones for the treatment of a particular Disease/Gene/Mutation of a patient, thereby enabling medical experts to personalize a therapy to be administered to a patient.

Abstract translation: 提供了用于突变优先化的方法和装置，其有助于患者的个性化治疗。 此外，提供了用于产生疾病知识库的方法和装置。 可以确定在各种知识来源中存在关于<疾病，基因，突变>集合的特定关联的信息。 所识别的信息相对于疾病知识库进行排名，以找出用于治疗患者的特定疾病/基因/突变的最相关的信息，从而使医学专家能够个性化要施用于患者的治疗。

公开(公告)号：US20190325986A1

公开(公告)日：2019-10-24

申请号：US16391581

申请日：2019-04-23

Applicant: Samsung Electronics Co., Ltd.

Inventor： Garima AGARWAL ,  Tadi Venkata SIVA KUMAR ,  Rajasekhara Reddy DUVVURU MUNI ,  Taeyong KIM

IPC: G16B15/30 ,  G16B15/20 ,  G16B35/20 ,  G16B40/20 ,  G16B45/00 ,  G16C60/00 ,  G16C20/50 ,  G16C20/64 ,  G16C20/70

Abstract: A method of predicting an amino acid substitution includes: receiving input of information regarding a structure of an enzyme along with the site of the enzyme in proximity to a bound ligand; identifying a functional atom of a wild type (WT) amino acid at the site of interest and a functional atom of the ligand; confirming properties of the functional atom of the WT amino acid and the functional atom of the ligand; detecting whether an interaction exists between the functional atom of the WT amino acid and the functional atom of the ligand; selecting alternative amino acids according to a result of the detecting of the interaction; determining a score for each of the selected alternative amino acids, respectively; ranking the selected alternative amino acids, based on the scores; and predicting substitutions of alternative amino acids having high rankings from among the selected alternative amino acids.