公开(公告)号：US20130129731A1

公开(公告)日：2013-05-23

申请号：US13679852

申请日：2012-11-16

Applicant: Samsung Electronics Co., Ltd.

Inventor： Bo-gyou KIM ,  Yun-ju JEONG ,  Kyung-ah KIM ,  Kwang-ho CHEONG ,  Seung-hyun LEE

IPC: C07K16/40

CPC classification number: C07K16/40 ,  C07K16/2863 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/74 ,  C07K2317/75 ,  C07K2317/92

Abstract: An anti c-Met antibody or antigen-binding fragment thereof comprising a heavy-chain variable region having heavy-chain complementarity determining region (CDR) amino acid sequences of SEQ ID NOs: 1, 2 and 3, and a light-chain variable region having light-chain CDR amino acid sequences of SEQ ID NOs: 4, 5, and 6; and a method of wound healing, tissue regeneration, or cell proliferation comprising administration of same; as well as related compositions and methods.

Abstract translation: 包含具有SEQ ID NO：1,2和3的重链互补决定区（CDR）氨基酸序列的重链可变区的抗c-Met抗体或其抗原结合片段和轻链可变区 具有SEQ ID NO：4,5和8的轻链CDR氨基酸序列; 以及伤口愈合，组织再生或细胞增殖的方法，包括施用它们; 以及相关的组合物和方法。

公开(公告)号：US20140200156A1

公开(公告)日：2014-07-17

申请号：US14156212

申请日：2014-01-15

Applicant: Samsung Electronics Co., Ltd.

Inventor： Bo-gyou KIM ,  Kyung-ah KIM ,  Dae-soon SON ,  Eun-jin LEE

IPC: G01N33/50

CPC classification number: G01N33/5023 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158

Abstract: Biomarkers for screening drugs reducing side effects of anti-c-Met antibodies and a method of screening using the biomarkers, and more particularly, biomarkers commonly enhancing or reducing gene expression and a method of screening anti-c-Met antibodies having reduced side effects using the biomarkers or a method of screening drugs that reduce side effects of anti-c-Met antibodies.

Abstract translation: 用于筛选药物以减少抗c-Met抗体的副作用的生物标志物和使用生物标志物进行筛选的方法，更具体地，通常增强或降低基因表达的生物标志物以及筛选具有降低的副作用的抗c-Met抗体的方法 生物标志物或筛选减少抗c-Met抗体副作用的药物的方法。