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公开(公告)号：US20220002425A1
公开(公告)日：2022-01-06
申请号：US16615124
申请日：2018-06-22
发明人： Yi ZHU , Ole OLSEN , Dong XIA , David JELLYMAN , Katrina BYKOVA , Anne-Marie K. ROUSSEAU , Bill BRADY , Blair RENSHAW , Brian KOVACEVICH , Yu LIANG , Camilla WANG , Zeren GAO
摘要： The application provides guidance and navigation control (GNC) proteins. In one embodiment, the GNC protein Comprises a T-cell binding moiety and a cancer-targeting moiety, wherein the T-cell binding moiety has a binding specificity to a T-cell receptor comprising CD3, CD28, PDL1, PD1, OX40, 4-1BB, GITR, TIGIT, TIM-3, LAG-3, CTLA4, CD40, VISTA, ICOS, BTLA, Light, NKp30, CD28H, CD27, CD226, CD96, CD112R, A2AR, CD160, CD244, CECAM1, CD200R, TNFRSF25 (DR3), or a combination thereof, and wherein the cancer targeting moiety has a binding specificity to a cancer cell receptor.
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公开(公告)号：US20220002406A1
公开(公告)日：2022-01-06
申请号：US16615122
申请日：2018-06-22
发明人： Yi ZHU , Ole OLSEN , Dong XIA , David JELLYMAN , Katrina BYKOVA , Anne-Marie K. ROUSSEAU , Bill BRADY , Blair RENSHAW , Brian KOVACEVICH , Yu LIANG , Zeren GAO
摘要： The disclosure provides a tetra-specific antibody monomer having a N-terminal and a C-terminal, comprising in tandem from the N-terminal to the C-terminal, a first scFv domain at the N-terminal, a Fab domain, a Fc domain, a second scFv domain, and a third scFv at the C-terminal, wherein the first scFv domain, the Fab domain, the second scFv domain, and the third scFv domain each has a binding specificity against a different antigen. In one embodiment, the antigen is a tumor antigen, an immune signaling antigen, or a combination thereof. Multi-specific antibodies comprising the disclosed tetra-specific antibodies are also provided.
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公开(公告)号：US20200157224A1
公开(公告)日：2020-05-21
申请号：US16615123
申请日：2018-06-22
发明人： Yi ZHU , Ole OLSEN , Dong XIA , David JELLYMAN , Katrina BYKOVA , Anne-Marie K. ROUSSEAU , Bill BRADY , Blair RENSHAW , Brian KOVACEVICH , Yu LIANG , Zeren GAO
摘要： The disclosure provides a tetra-specific antibody monomer having a N-terminal and a C-terminal, comprising in tandem from the N-terminal to the C-terminal, a first scFv domain at the N-terminal, a second scFv domain, a Fab domain, a Fc domain, and a third scFv at the C-terminal, wherein the first scFv domain, the second scFv domain, the Fab domain, and the third scFv domain each has a binding specificity against a different antigen. In one embodiment, the antigen is a tumor antigen, an immune signaling antigen, or a combination thereof. In one embodiment, the antigen includes CD19, CD3, CD137, 4-1BB, and PD-L1. Multi-specific antibodies comprising the disclosed tetra-specific antibodies are also provided.
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公开(公告)号：US20200157213A1
公开(公告)日：2020-05-21
申请号：US16615117
申请日：2018-06-22
发明人： Yi ZHU , Ole OLSEN , Dong XIA , David JELLYMAN , Katrina BYKOVA , Anne-Marie K. ROUSSEAU , Bill BRADY , Blair RENSHAW , Brian KOVACEVICH , Yu LIANG , Zeren GAO
IPC分类号： C07K16/28 , A61K47/68 , A61K39/395 , A61K45/06
摘要： The application provides tri-specific antibody monomers having a N-terminal and a C-terminal, comprising in tandem from the N-terminal to the C-terminal, a first scFv domain at the N-terminal, a Fab domain, a Fc domain, and a second scFv domain at the C-terminal. In one embodiment, the first scFv domain, the Fab domain, and the second scFv domain each has a binding specificity against a different antigen.
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公开(公告)号：US20240279333A1
公开(公告)日：2024-08-22
申请号：US18459019
申请日：2023-08-30
发明人： Yi ZHU , Ole OLSEN , Dong XIA , David JELLYMAN , Katrina BYKOVA , Anne-Marie K. ROUSSEAU , Bill BRADY , Blair RENSHAW , Brian KOVACEVICH , Yu LIANG , Zeren GAO
CPC分类号： C07K16/2809 , A61P35/02 , C07K16/2803 , C07K16/2827 , C07K16/2863 , C07K16/2878 , C07K2317/31 , C07K2317/52 , C07K2317/55 , C07K2317/622 , C07K2317/92
摘要： The disclosure provides a tetra-specific antibody monomer having a N-terminal and a C-terminal, comprising in tandem from the N-terminal to the C-terminal, a first scFv domain at the N-terminal, a Fab domain, a Fc domain, a second scFv domain, and a third scFv at the C-terminal, wherein the first scFv domain, the Fab domain, the second scFv domain, and the third scFv domain each has a binding specificity against a different antigen. In one embodiment, the antigen is a tumor antigen, an immune signaling antigen, or a combination thereof. Multi-specific antibodies comprising the disclosed tetra-specific antibodies are also provided.
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公开(公告)号：US20210024630A1
公开(公告)日：2021-01-28
申请号：US17040513
申请日：2019-03-26
发明人： Yi ZHU , Ole OLSEN , Dong XIA , David JELLYMAN , Katrina BYKOVA , Anne-Marie ROUSSEAU , Bill BRADY , Blair RENSHAW , Brian KOVACEVICH , Yu LIANG , Camilla WANG , Zeren GAO , Hui Huang
IPC分类号： C07K16/28 , A61P35/02 , C12N5/0783 , C12N5/09
摘要： The application provides guidance and navigation control (GNC) proteins. In one embodiment, the guidance and navigation control (GNC) protein, comprising a binding domain for a T cell activating receptor, a binding domain for a tumor associated antigen, a bind domain for an immune checkpoint receptor, and a binding domain for a T cell co-stimulating receptor. The binding domain for the tumor associated antigen is not adjacent to the binding domain for the T cell co-stimulating receptor. In one embodiment, the binding domain for the T cell activating receptor is adjacent to the binding domain for the tumor associated antigen (TAA).
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公开(公告)号：US20230322920A1
公开(公告)日：2023-10-12
申请号：US18296871
申请日：2023-04-06
发明人： Yi ZHU , Ole OLSEN , Dong XIA , David JELLYMAN , Katrina BYKOVA , Anne-Marie K. ROUSSEAU , Bill BRADY , Blair RENSHAW , Brian KOVACEVICH , Yu LIANG , Zeren GAO
IPC分类号： C07K16/28 , A61K47/68 , A61K39/395 , A61K45/06
CPC分类号： C07K16/2803 , A61K47/6803 , A61K39/3955 , A61K45/06 , C07K16/2809 , C07K16/2827 , C07K16/2863 , C07K2317/31 , C07K2317/55 , C07K2317/622 , C07K2317/73
摘要： The application provides tri-specific antibody monomers having a N-terminal and a C-terminal, comprising in tandem from the N-terminal to the C-terminal, a first scFv domain at the N-terminal, a Fab domain, a Fc domain, and a second scFv domain at the C-terminal. In one embodiment, the first scFv domain, the Fab domain, and the second scFv domain each has a binding specificity against a different antigen.
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