公开(公告)号：US3686183A

公开(公告)日：1972-08-22

申请号：US3686183D

申请日：1969-03-24

Applicant: SYNTEX CORP

Inventor： DYSON NORMAN H

IPC: B01D9/02 ,  C07C51/00 ,  C07C57/40 ,  C07C59/56 ,  C07C59/64 ,  C07C62/34 ,  C07C63/34 ,  C07C67/00 ,  C07C5/04

CPC classification number: C07C59/64 ,  C07C57/40 ,  C07C59/56 ,  C07C63/34

Abstract: SOLUTION OF A-SUBSTITUTED D- OR 1-ARYLACETIC ACID SALTS OF ASYMMERTIC OPTICALLY ACTIVE NITROGENEOUS BASES ARE HEATED TO ELEVATED TEMPERATURES TO CAUSE RACEMIZATION. BY REPEATED CRYSTALLIZATION AND RACEMIZATION STEPS WITH FINAL CONVERSION TO THE ACID, A DL-ACID CAN BE CONVERTED TO AN OPTICALLY SPECIFIC D- OR 1-ACID. THE A-SUBSTITUTED ARYLACETIC ACIDS ARE USEFUL AS ANTI-INFLAMMATORY, ANALGESIS, ANTIPYRETIC AND ANTI-PRUTITIC AGENTS.