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    Oral dosage form
    1.
    发明授权
    Oral dosage form 有权

    公开(公告)号：US11033589B2

    公开(公告)日：2021-06-15

    申请号：US16574402

    申请日：2019-09-18

    Applicant: Symrise AG

    Inventor： Rolf Daniels ,  Anja Hoffmann ,  Marcus Götz ,  Jörg Fischer ,  Kerstin Holmgren

    IPC: A61K35/747 ,  A61K9/00 ,  A61K9/20 ,  A61K35/00 ,  G01N33/50 ,  A61K9/19

    Abstract: The present invention is in the field of delivering an active substance to the oral cavity and relates to mucoadhesive active composition and corresponding mucoadhesive dosage form, which can deliver an active substance within the oral cavity, especially an orodispersible tablet for delivering probiotic substance. The present invention also relates to a method of producing the said composition and a method of processing the composition into a mucoadhesive dosage form, especially an orodispersible tablet. The present invention moreover relates to a system and a method for testing the mucoadhesion of a dosage form.

    ORAL DOSAGE FORM
    2.
    发明申请
    ORAL DOSAGE FORM 审中-公开

    公开(公告)号：US20200078422A1

    公开(公告)日：2020-03-12

    申请号：US16574402

    申请日：2019-09-18

    Applicant: Symrise AG

    Inventor： Rolf DANIELS ,  Anja Hoffmann ,  Marcus Götz ,  Jörg Fischer ,  Kerstin Holmgren

    IPC: A61K35/747 ,  G01N33/50 ,  A61K9/20 ,  A61K9/00

    Abstract: The present invention is in the field of delivering an active substance to the oral cavity and relates to mucoadhesive active composition and corresponding mucoadhesive dosage form, which can deliver an active substance within the oral cavity, especially an orodispersible tablet for delivering probiotic substance. The present invention also relates to a method of producing the said composition and a method of processing the composition into a mucoadhesive dosage form, especially an orodispersible tablet. The present invention moreover relates to a system and a method for testing the mucoadhesion of a dosage form.

    Compounds and Mixtures Influencing Inflammatory States
    3.
    发明申请
    Compounds and Mixtures Influencing Inflammatory States 审中-公开
    影响炎症状态的化合物和混合物

    公开(公告)号：US20130251730A1

    公开(公告)日：2013-09-26

    申请号：US13782391

    申请日：2013-03-01

    Applicant: SYMRISE AG

    Inventor： Jakob Ley ,  Katharina Reichelt ,  Marcus Götz ,  Maria Blings ,  Veronika Somoza ,  Jessica Walker ,  Joel Michael Walker

    IPC: A61K31/192 ,  C07D311/58 ,  A23L1/30 ,  C07D311/32 ,  A61K45/06 ,  C07C65/40 ,  A61K31/353

    CPC classification number: A61K31/192 ,  A23L33/105 ,  A61K8/365 ,  A61K8/498 ,  A61K31/352 ,  A61K31/353 ,  A61K45/06 ,  A61K2800/10 ,  A61Q19/00 ,  C07C65/40 ,  C07D311/32 ,  C07D311/58 ,  A61K2300/00

    Abstract: Suggested is a compound of the formula (X) or any salt of a compound of the formula (X) or any mixture containing or consisting of two or more different compounds of the formula (X), two or more different salts of compounds of the formula (X) or one or more different compounds of the formula (X) and one or more different salts of compounds of the formula (X), wherein for R1, R2 and R3 independently of one another in every compound of the formula (X) the following applies: R1 means hydrogen or methyl, R2 means an organic residue with 5 carbon atoms and one oxygen atom or none and R3 means an organic residue with 10 carbon atoms and one or more oxygen atoms, or R1 and R2 together with the carbon atoms in positions 4 and 5 and the oxygen atom bound to the carbon atom in position 4 form a ring and comprise 5 carbon atoms and one oxygen atom or none, and R3 means an organic residue with 10 carbon atoms and one or more oxygen atoms, for use in a method for the prophylaxis and/or treatment of inflammation.

    Abstract translation: 建议式（X）的化合物或式（X）化合物的任何盐或含有两种或更多种不同式（X）化合物的任何混合物或两种或更多种不同的 式（X）或一种或多种不同的式（X）化合物和一种或多种式（X）化合物的不同盐，其中对于R 1，R 2和R 3在每个式（X ）适用：R 1表示氢或甲基，R 2表示具有5个碳原子和一个氧原子的有机残基或不表示R 3表示具有10个碳原子和一个或多个氧原子的有机残基，或R 1和R 2与 位置4和5中的碳原子和结合到位置4的碳原子的氧原子形成环，并且包含5个碳原子和一个氧原子或不存在，并且R 3表示具有10个碳原子和一个或多个氧原子的有机残基 ，用于预防和/或治疗的方法 炎症。

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