公开(公告)号：US11117862B2

公开(公告)日：2021-09-14

申请号：US16863020

申请日：2020-04-30

申请人： Supernus Pharmaceuticals, Inc.

发明人： Martin Hanbauer ,  Zarghun Nazir ,  Peter Hildebrand ,  Attilia Figini ,  Likan Liang ,  Tiziano Fumagalli

IPC分类号： C07D209/08 ,  C07D295/13

摘要： The present invention is directed towards novel methods of synthesis of molindone, synthesis of the intermediates of molindone, and high-purity compositions of molindone. In particular, the invention relates to the methods of synthesis of molindone through the Mannich reaction.

公开(公告)号：US09802893B2

公开(公告)日：2017-10-31

申请号：US15365566

申请日：2016-11-30

申请人： Supernus Pharmaceuticals, Inc.

发明人： Martin Hanbauer ,  Zarghun Nazir ,  Peter Hildebrand ,  Attilia Figini ,  Likan Liang ,  Tiziano Fumagalli

IPC分类号： C07D209/08 ,  C07D295/13

CPC分类号： C07D209/08 ,  C07D295/13

摘要： The present invention is directed towards novel methods of synthesis of molindone, synthesis of the intermediates of molindone, and high-purity compositions of molindone. In particular, the invention relates to the methods of synthesis of molindone through the Mannich reaction.

公开(公告)号：US10676432B2

公开(公告)日：2020-06-09

申请号：US16107836

申请日：2018-08-21

申请人： Supernus Pharmaceuticals, Inc.

发明人： Martin Hanbauer ,  Zarghun Nazir ,  Peter Hildebrand ,  Attilia Figini ,  Likan Liang ,  Tiziano Fumagalli

IPC分类号： C07D209/08 ,  C07D295/13

摘要： The present invention is directed towards novel methods of synthesis of molindone, synthesis of the intermediates of molindone, and high-purity compositions of molindone. In particular, the invention relates to the methods of synthesis of molindone through the Mannich reaction.

公开(公告)号：US10081595B2

公开(公告)日：2018-09-25

申请号：US15723515

申请日：2017-10-03

申请人： Supernus Pharmaceuticals, Inc.

发明人： Martin Hanbauer ,  Zarghun Nazir ,  Peter Hildebrand ,  Attilia Figini ,  Likan Liang ,  Tiziano Fumagalli

IPC分类号： C07D209/08 ,  C07D295/13

CPC分类号： C07D209/08 ,  C07D295/13

摘要： The present invention is directed towards novel methods of synthesis of molindone, synthesis of the intermediates of molindone, and high-purity compositions of molindone. In particular, the invention relates to the methods of synthesis of molindone through the Mannich reaction.

公开(公告)号：US08957206B2

公开(公告)日：2015-02-17

申请号：US13834097

申请日：2013-03-15

申请人： Supernus Pharmaceuticals Inc.

发明人： Martin Hanbauer ,  Zarghun Nazir ,  Peter Hildebrand ,  Attilia Figini ,  Likan Liang ,  Tiziano Fumagalli

IPC分类号： C07D413/12 ,  C07D209/08

CPC分类号： C07D209/08 ,  C07D295/13

摘要： The present invention is directed towards novel methods of synthesis of molindone, synthesis of the intermediates of molindone, and high-purity compositions of molindone. In particular, the invention relates to the methods of synthesis of molindone through the Mannich reaction.

摘要翻译： 本发明涉及新戊烯二酮的合成方法，莫丹多酮的中间体的合成，以及莫丹多酮的高纯度组合物。 特别地，本发明涉及通过曼尼希反应合成莫林多酮的方法。

公开(公告)号：US20200262789A1

公开(公告)日：2020-08-20

申请号：US16863020

申请日：2020-04-30

申请人： Supernus Pharmaceuticals, Inc.

发明人： Martin Hanbauer ,  Zarghun Nazir ,  Peter Hildebrand ,  Attilia Figini ,  Likan Liang ,  Tiziano Fumagalli

IPC分类号： C07D209/08 ,  C07D295/13

摘要： The present invention is directed towards novel methods of synthesis of molindone, synthesis of the intermediates of molindone, and high-purity compositions of molindone. In particular, the invention relates to the methods of synthesis of molindone through the Mannich reaction.

公开(公告)号：US09562011B2

公开(公告)日：2017-02-07

申请号：US14608262

申请日：2015-01-29

申请人： Supernus Pharmaceuticals Inc.

发明人： Martin Hanbauer ,  Zarghun Nazir ,  Peter Hildebrand ,  Attilia Figini ,  Likan Liang ,  Tiziano Fumagalli

IPC分类号： C07D209/08

CPC分类号： C07D209/08 ,  C07D295/13

摘要： The present invention is directed towards novel methods of synthesis of molindone, synthesis of the intermediates of molindone, and high-purity compositions of molindone. In particular, the invention relates to the methods of synthesis of molindone through the Mannich reaction.

摘要翻译： 本发明涉及新戊烯二酮的合成方法，莫丹多酮的中间体的合成，以及莫丹多酮的高纯度组合物。 特别地，本发明涉及通过曼尼希反应合成莫林多酮的方法。

公开(公告)号：US20140081020A1

公开(公告)日：2014-03-20

申请号：US13834097

申请日：2013-03-15

申请人： SUPERNUS PHARMACEUTICALS INC.

发明人： Martin Hanbauer ,  Zarghun Nazir ,  Peter Hildebrand ,  Attilia Figini ,  Likan Liang ,  Tiziano Fumagalli

IPC分类号： C07D209/08

CPC分类号： C07D209/08 ,  C07D295/13

摘要： The present invention is directed towards novel methods of synthesis of molindone, synthesis of the intermediates of molindone, and high-purity compositions of molindone. In particular, the invention relates to the methods of synthesis of molindone through the Mannich reaction.

摘要翻译： 本发明涉及新戊烯二酮的合成方法，莫丹多酮的中间体的合成，以及莫丹多酮的高纯度组合物。 特别地，本发明涉及通过曼尼希反应合成莫林多酮的方法。