公开(公告)号：US3763190A

公开(公告)日：1973-10-02

申请号：US3763190D

申请日：1972-04-19

Applicant: STANFORD RESEARCH INST

Inventor： MC DONALD G ,  ROSS D ,  BARRETT H

IPC: C07D319/12 ,  C07D15/16

CPC classification number: C07D319/12

Abstract: GLYCOLIDE IS PREPARED IN HIGHLY PURE FORM FROM OHALOACETYLGLYCOLIC ACID SALTS BY ELIMINATION OF A MINERAL ACID SALT AND ATTENDANT CLOSURE OF THE RING. IN A TYPICAL PREPARATION, THE NOVEL COMPOUND O-CHLOROACETYLGLYCOLIC ACID IS CONVERTED TO A SALT AND GLYCOLIDE IS THEN FORMED AS THE SALT IS HEATED IN A VACUUM SUBLIMATION APPARATUS WHEREIN THE GLYCOLIDE CONDENSES ON A COOL SURFACE. THE GLYCOLIDE CAN BE POLYMERIZED TO FORM POLYGLYCOLIC ACID OF HIGH PURITY WHICH IS USEFUL IN THE FABRICATION OF SUTURES WHICH ARE ABSORBABLE IN BODY FLUIDS.