公开(公告)号：US20240343761A1

公开(公告)日：2024-10-17

申请号：US18744292

申请日：2024-06-14

Applicant: SOCPRA SCIENCES SANTÉ ET HUMAINES S.E.C.

Inventor： Philippe SARRET ,  Pierre-Luc BOUDREAULT ,  Alexandre MURZA ,  Kien TRAN ,  Éric MARSAULT ,  Jean-Michel LONGPRÉ ,  Jérôme CÔTÉ

IPC: C07K7/56 ,  A61K38/00 ,  A61P9/02

CPC classification number: C07K7/56 ,  A61P9/02 ,  A61K38/00

Abstract: Aperlinergic macrocyclic compounds are provided. In particular, a compound of formula (II):




or a stereoisomer or a mixture thereof, or a pharmaceutically acceptable salt, ester or solvate thereof is provided. Also provided is a method of using aperlinergic macrocyclic compounds of the disclosure for treating a cardiovascular disease in a subject in need thereof, comprising administering an effective amount of the compound to the subject.

公开(公告)号：US20210213118A1

公开(公告)日：2021-07-15

申请号：US17250734

申请日：2019-08-30

Applicant: IMMUNE BIOSOLUTIONS INC ,  SOCPRA SCIENCES SANTÉ ET HUMAINES S.E.C.

Inventor： Eric MARSAULT ,  Pierre-Luc BOUDREAULT ,  Hassan TRABOULSI ,  Philippe SARRET ,  Marie-Édith NEPVEU-TRAVERSY ,  Simon GAUDREAU ,  Frédéric LEDUC ,  Jeam-François LARRIVÉE ,  Mathieu ARCAND

IPC: A61K39/00 ,  A61P35/00 ,  C07K16/28 ,  A61K47/64

Abstract: Antibodies and antigen-binding fragments thereof that specifically recognize Neurotensin receptor type 1 (NTSR1) are described. These anti-NTSR1 antibodies and antigen-binding fragments thereof, such as single-chain Fv (scFv), are able to inhibit neurotensin-mediated activation of NTSR1 in normal and tumor cells. Methods and uses of antibodies and antigen-binding fragments thereof for treatment of diseases or conditions associated with NTSR1 activity, such as NTSR1-positive cancers or certain metabolic diseases, are also described. Cyclic peptides mimicking the conformation of the second extracellular loop of NTSR1 and capable of inducing the production of anti-NTSR1 antibodies in animals such as chickens are also described.