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    PHOTOIMMUNOTHERAPY AND PHARMACEUTICAL AGENT USED THEREFOR
    2.
    发明申请
    PHOTOIMMUNOTHERAPY AND PHARMACEUTICAL AGENT USED THEREFOR 有权

    公开(公告)号：US20220152204A1

    公开(公告)日：2022-05-19

    申请号：US17440461

    申请日：2020-03-19

    Applicant: SHIMADZU CORPORATION

    Inventor： Taka-Aki SATO ,  Akihiro ISHIKAWA ,  Masayuki NISHIMURA

    IPC: A61K41/00 ,  A61K47/64 ,  A61P35/02

    Abstract: Provided is a method and pharmaceutical agent which make it possible to efficiently implement PIT, and a method characterized by a step of administering a pharmaceutical agent, in which a substance that binds to tumor blood vessel specific marker molecules present in new blood vessels has been conjugated with at least a labeling substance, to an object associated with a disease or pathology, and changing a physical property of the labeling substance after the administration step.

    BRAIN FUNCTION MEASUREMENT DEVICE
    3.
    发明申请
    BRAIN FUNCTION MEASUREMENT DEVICE 有权

    公开(公告)号：US20220095921A1

    公开(公告)日：2022-03-31

    申请号：US17427163

    申请日：2019-12-23

    Applicant: SHIMADZU CORPORATION

    Inventor： Shumpei YAMAGUCHI ,  Akihiro ISHIKAWA

    IPC: A61B5/00 ,  A61B5/055 ,  A61B5/026

    Abstract: This brain function measurement device (100) includes a brain blood flow information acquisition unit (1) that acquires brain blood flow information (d1) of a subject (P), a brain function information acquisition unit (30) that acquires brain function correlation information (d3) indicating a relative change in a correlation between respective portions of the brain acquired on the basis of the brain blood flow information measured in a plurality of portions of a brain before and after a task is presented, and a brain function image generation unit (7) that generates a first brain function image (20) in which a relative position of each measurement position (23) for the brain blood flow information and the measurement position at which the correlation acquired on the basis of the brain function correlation information has changed are visually recognizable.

    TREATMENT SUPPORT SYSTEM AND TREATMENT SUPPORT DEVICE
    4.
    发明申请
    TREATMENT SUPPORT SYSTEM AND TREATMENT SUPPORT DEVICE 有权

    公开(公告)号：US20220054855A1

    公开(公告)日：2022-02-24

    申请号：US17370780

    申请日：2021-07-08

    Applicant: Shimadzu Corporation

    Inventor： Akihiro ISHIKAWA

    IPC: A61N5/06

    Abstract: A treatment support system is provided with an irradiation unit for irradiating a medical agent containing a fluorescent material with treatment light, a light detection unit for detecting, out of the treatment light and fluorescence, at least the fluorescence, a storage uni, and a control unit. The control unit performs control of at least a start of storing the fluorescence signal by the storage unit based on that the fluorescence signal detected by the light detection unit has changed beyond at least a predetermined degree of change; or that the light detection unit has detected the signal of the treatment light.

    IMAGING DEVICE
    5.
    发明申请
    IMAGING DEVICE 审中-公开

    公开(公告)号：US20200022580A1

    公开(公告)日：2020-01-23

    申请号：US16039538

    申请日：2018-07-19

    Applicant: Shimadzu Corporation

    Inventor： Akihiro ISHIKAWA

    IPC: A61B5/00 ,  A61M5/00

    Abstract: An imaging device which can easily recognize the timing of administration of a fluorescent dye through reproduction of recorded images. When indocyanine green is administered, an operator manipulates an input unit so that the input unit sends to a controller a signal indicating that indocyanine green has been administered to a subject. When the controller receives the signal indicating that indocyanine green has been administered to the subject, a light source controller turns a fluorescent light source on, and then off after a lapse of a predetermined time.

    OPTICAL BIOMETRIC DEVICE AND POSITION MEASURING DEVICE USED THEREIN
    6.
    发明申请
    OPTICAL BIOMETRIC DEVICE AND POSITION MEASURING DEVICE USED THEREIN 审中-公开
    光学生物量装置及其使用的位置测量装置

    公开(公告)号：US20150342461A1

    公开(公告)日：2015-12-03

    申请号：US14442690

    申请日：2012-11-14

    Applicant: SHIMADZU CORPORATION

    Inventor： Akihiro ISHIKAWA ,  Shumpei YAMAGUCHI

    IPC: A61B5/00 ,  A61B5/05

    CPC classification number: A61B5/0042 ,  A61B5/0035 ,  A61B5/0059 ,  A61B5/0073 ,  A61B5/05 ,  A61B5/055 ,  A61B5/145 ,  A61B5/7425 ,  A61B5/7445 ,  A61B2560/0475 ,  A61B2562/0223 ,  A61B2562/0233 ,  A61B2562/0238

    Abstract: The optical biometric device according to the invention is provided with: a measurement data display control unit for displaying a number of pieces of measurement data on the three-dimensional head surface image or three-dimensional brain surface image displayed on the display unit, and is formed of: a storage unit for storing channel information that indicates combinations of light sending probes and light receiving probes for acquiring information about the amounts of the received light in measurement portions; and a channel information display control unit for displaying a number of light sending probe points at which light sending probes have been placed and a number of light receiving probe points at which a number of light receiving probes have been placed according to the three-dimensional coordinates displayed on the display unit, and at the same time, for displaying line segments that indicate combinations of light sending probes and light receiving probes for connecting light sending probe points and light receiving probe points based on said channel information.

    Abstract translation: 根据本发明的光学生物测定装置设置有：测量数据显示控制单元，用于在显示单元上显示的三维头表面图像或三维脑表面图像上显示多条测量数据，并且是 形成为：存储单元，用于存储指示发光探针和光接收探针的组合的通道信息，用于获取关于测量部分中的接收光量的信息; 以及频道信息显示控制单元，用于根据三维坐标显示已经放置发光探针的多个发光探针点和已经放置了多个光接收探针的多个光接收探针点 显示在显示单元上，同时，用于显示基于所述通道信息显示用于连接发光探针点和光接收探针点的发光探针和光接收探针的组合的线段。

    TREATMENT SUPPORT APPARATUS AND IMAGE GENERATION METHOD
    7.
    发明申请
    TREATMENT SUPPORT APPARATUS AND IMAGE GENERATION METHOD 有权

    公开(公告)号：US20220287549A1

    公开(公告)日：2022-09-15

    申请号：US17635207

    申请日：2020-02-10

    Applicant: SHIMADZU CORPORATION

    Inventor： Akihiro ISHIKAWA

    IPC: A61B1/04 ,  A61B1/00 ,  A61B5/00 ,  A61N5/06

    Abstract: A treatment support apparatus (100) includes an excitation light source (21) configured to irradiate a fluorescent substance (301) of a drug (300) administered into a cancer patient's (200) body with excitation light in a specific waveband having energy that excites the fluorescent substance (301) but does not kill a cancer cell (301) before or after treatment to kill the cancer cell (201) based on irradiating the drug (300) containing the fluorescent substance (301) with light in a specific waveband, a fluorescence detector (26) configured to detect fluorescence emitted by the fluorescent substance (301) of the drug (300) due to excitation by the excitation light, and an image generator (16) configured to generate a fluorescence distribution image (41), which is an image showing a distribution state of the fluorescence emitted by the fluorescent substance (301), based on the fluorescence from the fluorescent substance (301) detected by the fluorescence detector (26).

    IMAGING DEVICE AND METHOD
    8.
    发明申请
    IMAGING DEVICE AND METHOD 审中-公开

    公开(公告)号：US20200022655A1

    公开(公告)日：2020-01-23

    申请号：US16039536

    申请日：2018-07-19

    Applicant: Shimadzu Corporation

    Inventor： Akihiro ISHIKAWA

    IPC: A61B5/00 ,  G06T5/00

    Abstract: An imaging device and method which can easily obtain a curve of time-varying changes in pixel value of a region of interest, even if the region of interest moves with a subject's body motion. A controller includes an image processor executing various types of image processing on fluorescence images and visible light images. The image processor includes a pixel value measurement unit which sequentially measures values of pixels at positions corresponding to a region of interest (ROI) in the fluorescence image, a change curve creation unit which creates a curve of time-varying changes in pixel value of the ROI by sampling, among the pixel values measured by the pixel value measurement unit, a minimum pixel value within a period equal to or longer than a cycle of the subject's body motion, and a smoothing unit which smooths the curve created by the change curve creation unit.

    NEAR-NFRARED IMAGING APPARATUS AND MARKER MEMBER FOR NEAR-INFRARED IMAGING APPARATUS
    9.
    发明申请
    NEAR-NFRARED IMAGING APPARATUS AND MARKER MEMBER FOR NEAR-INFRARED IMAGING APPARATUS 审中-公开

    公开(公告)号：US20190175301A1

    公开(公告)日：2019-06-13

    申请号：US16302770

    申请日：2016-06-09

    Applicant: SHIMADZU CORPORATION

    Inventor： Akihiro ISHIKAWA

    IPC: A61B90/00 ,  A61B5/00

    Abstract: A near-infrared imaging apparatus according to the present invention comprises: an excitation light source unit that irradiates a fluorescent agent within a patient P with near-infrared excitation light; a marker member including a marker light source unit that generates near-infrared light; a near-infrared sensor that detects near-infrared light and near-infrared fluorescent light generated by the fluorescent agent; and an image forming unit that captures an image of the detected near-infrared light and near-infrared fluorescent light.

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