公开(公告)号：US20240207396A1

公开(公告)日：2024-06-27

申请号：US18557597

申请日：2021-07-13

申请人： SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES

发明人： Fei LIU ,  Dandan YUAN ,  lei CHEN ,  Linlin NIU ,  Mian CHEN ,  Huarong SHAO ,  Xiaogang ZHANG ,  Yingmei LIU ,  Jinhua ZHANG ,  Mengqi DIAO ,  Xinyan GUO

IPC分类号： A61K39/39 ,  A61K39/00 ,  A61P31/10 ,  A61P37/04

CPC分类号： A61K39/39 ,  A61P31/10 ,  A61P37/04 ,  A61K2039/57 ,  A61K2039/6087

摘要： An oligosaccharide vaccine for specific prevention of fungal infections and a method for preparing the same are provided. The vaccine is formed by conjugating a sulfhydrylated protein with oligosaccharide. The sulfhydrylated protein is formed by introducing a sulfhydryl group (—SH) to a carrier protein containing a primary amino group (—NH2), and then is conjugated with the oligosaccharide to form the oligosaccharide vaccine under the binding action of a bridging agent. The carrier protein is a non-humanized protein, and the oligosaccharide is a chitosan oligosaccharide mixture and/or chitin oligosaccharide mixture. The vaccine has strong immunogenicity, can activate Th17 cell immunity, and can recognize and protect infections caused by fungi.