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公开(公告)号：US20190085051A1
公开(公告)日：2019-03-21
申请号：US16128633
申请日：2018-09-12
申请人： Senomyx , Inc.
IPC分类号： C07K14/72 , C07K14/705
CPC分类号： C07K14/723 , C07K14/705 , C07K2319/00
摘要： Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are provided. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are provided, along with methods for isolating such genes and for isolating and expressing such receptors.
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公开(公告)号：US20170313761A1
公开(公告)日：2017-11-02
申请号：US15483353
申请日：2017-04-10
申请人： Senomyx, Inc.
IPC分类号： C07K14/72 , C07K14/705
CPC分类号： C07K14/723 , C07K14/705 , C07K2319/00
摘要： Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are provided. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are provided, along with methods for isolating such genes and for isolating and expressing such receptors.
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公开(公告)号：US20180086815A1
公开(公告)日：2018-03-29
申请号：US15784352
申请日：2017-10-16
申请人： SENOMYX, INC.
CPC分类号： C07K14/723 , C07K14/705 , C07K2319/00 , C12Q1/6883 , G01N33/5041 , G01N33/6872 , G01N33/74 , G01N2333/726 , G16B5/00
摘要： Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular taste stimulus in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal are also disclosed.
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4.发明申请公开(公告)号：US20180003702A1
公开(公告)日：2018-01-04
申请号：US15244135
申请日：2016-08-23
申请人： SENOMYX, INC.
发明人： Xiaodong LI , Lena LUUKKONEN , Hong XU
IPC分类号： G01N33/543 , A23L27/00 , A23L27/20 , G01N33/566 , G01N33/50 , C07F9/655 , C07D405/12 , C07D317/68 , C07D307/84 , C07C275/34 , C07C275/30 , C07C235/54 , C07C233/65 , A61K47/24 , A61K47/22 , A61K8/55 , A61K8/49 , A23L2/56 , G01N33/74
CPC分类号： G01N33/543 , A23L2/56 , A23L27/202 , A23L27/203 , A23L27/2054 , A23L27/88 , A23V2002/00 , A61K8/4973 , A61K8/55 , A61K47/22 , A61K47/24 , C07C233/65 , C07C235/54 , C07C275/30 , C07C275/34 , C07D209/08 , C07D209/42 , C07D213/40 , C07D213/81 , C07D213/85 , C07D215/48 , C07D217/06 , C07D231/14 , C07D261/18 , C07D263/56 , C07D271/12 , C07D275/03 , C07D277/64 , C07D285/135 , C07D307/52 , C07D307/68 , C07D307/79 , C07D307/82 , C07D307/84 , C07D317/68 , C07D333/24 , C07D333/38 , C07D401/04 , C07D405/12 , C07D409/12 , C07D417/12 , C07F9/65517 , G01N33/5041 , G01N33/566 , G01N33/74 , G01N2333/726
摘要： The invention relates to compounds that specifically bind a T1R1/T1R3 or T1R2/T1R3 receptor or fragments or sub-units thereof. The present invention also relates to the use of hetero-oligomeric and chimeric taste receptors comprising T1R1/T1R3 and T1R2/T1R3 in assays to identify compounds that respectively respond to umami taste stimuli and sweet taste stimuli. Further, the invention relates to the constitutive of cell lines that stably or transiently co-express a combination of T1R1 and T1R3; or T1R2 and T1R3; under constitutive or inducible conditions. The use of these cells lines in cell-based assays to identify umami and sweet taste modulatory compounds is also provided, particularly high throughput screening assays that detect receptor activity by use of fluorometric imaging.
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