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公开(公告)号：US20220228127A1
公开(公告)日：2022-07-21
申请号：US17608587
申请日：2020-05-27
发明人： Yuuhei ARAI , Ryoma ISHII , Hiroki IGUCHI , Satoshi HANEDA
IPC分类号： C12N5/074
摘要： Provided is a resin film having excellent cell extensibility in cell culture. The resin film formed of a scaffold material for cell culture containing a synthetic resin, the resin film having a compressive modulus of 5.5 GPa or more at a frequency of 1 Hz as measured using a nanoindenter device in ion-exchanged water in accordance with ISO14577-1 after being immersed in the ion-exchanged water at 37° C. for 24 hours.
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公开(公告)号：US20240052301A1
公开(公告)日：2024-02-15
申请号：US18268476
申请日：2022-02-02
发明人： Satoshi HANEDA , Hiroki IGUCHI
IPC分类号： C12N5/00
CPC分类号： C12N5/0075 , C12N2531/00 , C12N2533/30
摘要： Provided is a microcarrier for cell culture in which adhesion between microcarriers due to a cell mass can be suppressed. The microcarrier for cell culture according to the present invention includes a base particle and a coating layer covering an outer surface of the base particle, and the coating layer includes a resin having a polyvinyl alcohol derivative skeleton or a poly(meth)acrylic acid ester skeleton and having a peptide moiety, and the microcarrier has an average particle size of 300 μm or more and a CV value of particle size of 10% or less.
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公开(公告)号：US20220177825A1
公开(公告)日：2022-06-09
申请号：US17599349
申请日：2020-03-27
发明人： Hiroki IGUCHI , Yuuta NAKAMURA , Ryoma ISHII , Yuuhei ARAI , Satoshi HANEDA
IPC分类号： C12M1/12
摘要： A scaffold material for cell culture having excellent cell colonization is provided. A scaffold material for cell culture according to the present invention includes a synthetic resin having a main chain and a graft chain, wherein the graft chain has a polydentate hydrogen-bonding group represented by the following formula (1) in a side chain: *—R-(Ai)n (1) wherein R represents a group having 50 or less carbon atoms, Ai represents an amino group, a carboxyl group, a hydroxyl group, a sulfone group, an imino group, or a thiol group, i represents a natural number, n represents an integer of two or more and four or less, and * represents a bonding position with another atom constituting the graft chain; and Ai may be identical or different from each other.
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4.发明公开公开(公告)号：US20230311126A1
公开(公告)日：2023-10-05
申请号：US18033726
申请日：2021-10-27
发明人： Yoshiki TOMITA , Takamasa KOUNO , Hiroki IGUCHI
IPC分类号： B01L3/00
CPC分类号： B01L3/502761 , B01L3/50273 , B01L2200/0647 , B01L2300/12 , B01L2200/141
摘要： Provided is a microfluidic chip capable of suppressing contamination while downsizing a device. A microfluidic chip 1 includes a chip main body 2, and an optical gas generation tape 8 attached to the chip main body 2 and configured to generate a gas by light irradiation, in which the chip main body 2 includes a microchannel 4, a liquid medium reservoir 5 provided in the middle of the microchannel 4, and a cell binding unit 6 provided on a downstream side of the liquid medium reservoir 5 in the microchannel 4, and a liquid medium stored in the liquid medium reservoir 5 is supplied to the cell binding unit 6 by the gas generated from the optical gas generation tape 8.
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公开(公告)号：US20220235307A1
公开(公告)日：2022-07-28
申请号：US17612451
申请日：2020-07-31
发明人： Yuuhei ARAI , Nobuhiko INUI , Satoshi HANEDA , Hiroki IGUCHI
IPC分类号： C12M1/12
摘要： Provided is a cell culture scaffold capable of allowing cell masses to be formed easily and efficiently. A cell culture scaffold according to the present invention includes a substrate; and a protrusion formed by patterning in a pattern of a dot or a line on the substrate, wherein the protrusion contains a synthetic resin, the synthetic resin contains at least a polyvinyl alcohol derivative or a poly(meth)acrylic resin, the protrusion has cell adhesion, and a portion of the protrusion located at the protrusion center position in plan view has an average height of 10 nm or more and 10 μm or less.
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公开(公告)号：US20220325221A1
公开(公告)日：2022-10-13
申请号：US17608008
申请日：2020-05-15
发明人： Kenta TAKAKURA , Mayumi YUKAWA , Daigo KOBAYASHI , Ryoma ISHII , Hiroki IGUCHI , Yuuhei ARAI , Satoshi HANEDA , Nobuhiko INUI
摘要： Provided is a cell culture scaffold material having excellent extensibility of pseudopodia and excellent cell proliferation. The cell culture scaffold material according to the present invention contains a peptide-conjugated polyvinyl alcohol derivative having a polyvinyl alcohol derivative portion and a peptide portion, and has a hydroxyl value of 1,100 mgKOH/g or less.
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公开(公告)号：US20220227898A1
公开(公告)日：2022-07-21
申请号：US17608044
申请日：2020-05-15
发明人： Hiroki IGUCHI , Yuuhei ARAI , Nobuhiko INUI , Mayumi YUKAWA , Daigo KOBAYASHI , Yuuta NAKAMURA , Kenta TAKAKURA , Satoshi HANEDA , Ryoma ISHII
摘要： Provided is a resin film formed of a cell culture scaffold material, which has excellent fixation of cells after seeding and is capable of enhancing proliferation rate of cells. A resin film formed of a cell culture scaffold material, in which the cell culture scaffold material contains a synthetic resin, and the resin film has phase-separated structure including least a first phase and a second phase, and a ratio of the surface area of one of the first phase and the second phase to the entire surface is 0.01 or more and 0.95 or less.
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公开(公告)号：US20210071147A1
公开(公告)日：2021-03-11
申请号：US16958218
申请日：2018-12-27
发明人： Satoshi HANEDA , Yuriko MANABE , Ryoma ISHII , Hiroki IGUCHI , Yuhei ARAI
IPC分类号： C12N5/074 , C12N5/0735 , C12M1/12 , C08F124/00
摘要： A scaffolding material for culturing a stem cell, which contains a synthetic resin, and has a storage elasticity at 100° C. of 1.0×104 Pa or more and 1.0×108 Pa or less, and a ratio between the storage elasticity at 25° C. and the storage elasticity at 100° C. ((storage elasticity at 25° C.)/(storage elasticity at 100° C.)) of 1.0×101 or more and 1.0×105 or less. The scaffolding material for stem cell culture has suitable hydrophilicity and strength, high fixation of stem cells after seeding, highly efficient cell proliferation, and excellent scratch resistance.
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公开(公告)号：US20220348858A1
公开(公告)日：2022-11-03
申请号：US17608062
申请日：2020-05-15
发明人： Daigo KOBAYASHI , Mayumi YUKAWA , Kenta TAKAKURA , Ryoma ISHII , Hiroki IGUCHI , Yuuhei ARAI , Satoshi HANEDA , Nobuhiko INUI
IPC分类号： C12M1/12 , C12N5/00 , C07K7/64 , C08F261/12 , C08J7/12 , C09D151/00
摘要： Provided is a cell culture scaffold material having excellent cell adhesion. The cell culture scaffold material according to the present invention contains a peptide-conjugated polyvinyl alcohol derivative having a polyvinyl alcohol derivative portion and a peptide portion, and the peptide portion has a cyclic peptide skeleton.
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公开(公告)号：US20200370009A1
公开(公告)日：2020-11-26
申请号：US16958182
申请日：2018-12-27
发明人： Satoshi HANEDA , Yuriko MANABE , Ryoma ISHII , Hiroki IGUCHI , Hiroshi YAMAUCHI , Takahiro OMURA
IPC分类号： C12N5/0735 , C12M3/00 , C08L79/02 , C12N5/00
摘要： A scaffolding material for culturing a stem cell, which contains a synthetic resin, and has a nitrogen content of the synthetic resin of 0.1% by mass or more and 10% by mass or less. According to the scaffolding material for stem cell culture, the scaffolding material can have suitable hydrophilicity and strength, high fixation of stem cells after seeding, and highly efficient cell proliferation.
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