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1.发明授权公开(公告)号：US11612658B2
公开(公告)日：2023-03-28
申请号：US16949237
申请日：2020-10-21
申请人： SANTEN SAS
IPC分类号： A61K9/107 , A61K47/18 , A61K9/00 , A61K31/765 , A61K38/13 , A61K31/14 , A61L12/14 , C07C211/63
摘要： Compositions containing quaternary compounds in which the nitrogen atom is substituted by at least one alkyl group having at least 12 carbon atoms, and the composition includes at least 20% in weight by weight of the total composition, of ammonium halides in which the nitrogen atom is substituted by at least one alkyl group having at least 14 carbon atoms and more than 5%, preferably more than 7% in weight by weight of the total composition, of ammonium halides in which the nitrogen atom is substituted by at least one alkyl group having at least 16 carbon atoms. Also, ophthalmic oil-in-water emulsions containing such compositions, the ophthalmic emulsions being useful for eye care or for the treatment of eye conditions.
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公开(公告)号：US09682147B2
公开(公告)日：2017-06-20
申请号：US14380655
申请日：2013-02-22
申请人： SANTEN SAS
IPC分类号： A61K47/02 , A61K9/107 , A61K31/5575 , A61K47/10 , A61K31/436 , A61K47/18 , A61K47/26 , A61K47/44 , A61K38/13 , A61K31/573 , A61K9/00 , A61K47/34 , A61K33/22
CPC分类号： A61K47/02 , A61K9/0048 , A61K9/107 , A61K9/1075 , A61K31/436 , A61K31/5575 , A61K31/573 , A61K33/22 , A61K38/13 , A61K47/10 , A61K47/186 , A61K47/26 , A61K47/34 , A61K47/44
摘要： The present invention relates to a self-preserved oil dispersion. Especially, the present invention relates to a self-preserved oil dispersion including a dispersed oil phase, an aqueous phase and at least one surfactant, wherein said oil dispersion comprises boric acid in an amount ranging from 0.005% to 0.075% in weight of the total weight of the oil dispersion, said amount of boric acid being a preservative effective amount so that the oil dispersion has a preservative activity.
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公开(公告)号：US09956289B2
公开(公告)日：2018-05-01
申请号：US14943649
申请日：2015-11-17
申请人： SANTEN SAS
IPC分类号： A61K9/107 , A61K9/00 , A61K38/13 , A01N33/12 , A01N25/04 , A01N25/30 , A61K47/18 , A61K31/14 , A61K31/765 , A61L12/14 , C07C211/63
CPC分类号： A61K47/186 , A61K9/0014 , A61K9/0048 , A61K9/107 , A61K31/14 , A61K31/765 , A61K38/13 , A61L12/143 , C07C211/63
摘要： Compositions containing quaternary compounds in which the nitrogen atom is substituted by at least one alkyl group having at least 12 carbon atoms, and the composition includes at least 20% in weight by weight of the total composition, of ammonium halides in which the nitrogen atom is substituted by at least one alkyl group having at least 14 carbon atoms and more than 5%, preferably more than 7% in weight by weight of the total composition, of ammonium halides in which the nitrogen atom is substituted by at least one alkyl group having at least 16 carbon atoms. Also, ophthalmic oil-in-water emulsions containing such compositions, the ophthalmic emulsions being useful for eye care or for the treatment of eye conditions.
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公开(公告)号：US20150025020A1
公开(公告)日：2015-01-22
申请号：US14380655
申请日：2013-02-22
申请人： SANTEN SAS
IPC分类号： A61K47/02 , A61K9/107 , A61K31/5575 , A61K47/10 , A61K31/436 , A61K31/573 , A61K47/18 , A61K47/26 , A61K47/44 , A61K38/13
CPC分类号： A61K47/02 , A61K9/0048 , A61K9/107 , A61K9/1075 , A61K31/436 , A61K31/5575 , A61K31/573 , A61K33/22 , A61K38/13 , A61K47/10 , A61K47/186 , A61K47/26 , A61K47/34 , A61K47/44
摘要： The present invention relates to a self-preserved oil dispersion. Especially, the present invention relates to a self-preserved oil dispersion including a dispersed oil phase, an aqueous phase and at least one surfactant, wherein said oil dispersion comprises boric acid in an amount ranging from 0.005% to 0.075% in weight of the total weight of the oil dispersion, said amount of boric acid being a preservative effective amount so that the oil dispersion has a preservative activity.
摘要翻译： 本发明涉及一种自保油油分散体。 特别地，本发明涉及包含分散油相，水相和至少一种表面活性剂的自保油分散体，其中所述油分散体包含的硼酸的含量占总重量的0.005-0.075％ 油分散体的重量，所述量的硼酸是防腐剂有效量，使得油分散体具有防腐活性。
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