公开(公告)号：US12071453B2

公开(公告)日：2024-08-27

申请号：US17952694

申请日：2022-09-26

Applicant: Sage Therapeutics, Inc.

Inventor： Gabriel Martinez Botella ,  Boyd L. Harrison ,  Albert Jean Robichaud ,  Francesco G. Salituro ,  Robert Jason Herr ,  Robert Borbo Kargbo

IPC: C07J43/00 ,  A61K31/58 ,  A61K45/06 ,  C07J7/00 ,  C07J1/00 ,  C07J13/00 ,  C07J21/00

CPC classification number: C07J43/003 ,  A61K31/58 ,  A61K45/06 ,  C07J1/0059 ,  C07J7/002 ,  C07J7/007 ,  C07J7/0085 ,  C07J13/007 ,  C07J21/00 ,  C07J21/008 ,  A61K31/58 ,  A61K2300/00

Abstract: Described herein are neuroactive steroids of the Formula (I): or a pharmaceutically acceptable salt thereof; wherein -------, R1, R2, R3, A and L are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use and treatment, e.g., such for inducing sedation and/or anesthesia.

公开(公告)号：US20210061848A1

公开(公告)日：2021-03-04

申请号：US16843822

申请日：2020-04-08

Applicant: Sage Therapeutics, Inc.

Inventor： Gabriel Martinez Botella ,  Boyd L. Harrison ,  Albert Jean Robichaud ,  Francesco G. Salituro ,  Robert Jason Herr ,  Robert Borbo Kargbo

IPC: C07J43/00 ,  A61K45/06 ,  A61K31/58

Abstract: Described herein are neuroactive steroids of the Formula (I): or a pharmaceutically acceptable salt thereof; wherein -------, R1, R2, R5, A and L are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use and treatment, e.g., such for inducing sedation and/or anesthesia.

公开(公告)号：US20240239836A9

公开(公告)日：2024-07-18

申请号：US17952694

申请日：2022-09-26

Applicant: Sage Therapeutics, Inc.

Inventor： Gabriel Martinez Botella ,  Boyd L. Harrison ,  Albert Jean Robichaud ,  Francesco G. Salituro ,  Robert Jason Herr ,  Robert Borbo Kargbo

IPC: C07J43/00 ,  A61K31/58 ,  A61K45/06

CPC classification number: C07J43/003 ,  A61K31/58 ,  A61K45/06 ,  C07J21/00

Abstract: Described herein are neuroactive steroids of the Formula (I): or a pharmaceutically acceptable salt thereof; wherein -----, R1, R2, R5, A and L are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use and treatment, e.g., such for inducing sedation and/or anesthesia.

公开(公告)号：US20230279044A1

公开(公告)日：2023-09-07

申请号：US17952694

申请日：2022-09-26

Applicant: Sage Therapeutics, Inc.

Inventor： Gabriel Martinez Botella ,  Boyd L. Harrison ,  Albert Jean Robichaud ,  Francesco G. Salituro ,  Robert Jason Herr ,  Robert Borbo Kargbo

IPC: C07J43/00 ,  A61K45/06 ,  A61K31/58

CPC classification number: C07J43/003 ,  A61K45/06 ,  A61K31/58 ,  C07J21/00

Abstract: Described herein are neuroactive steroids of the Formula (I): or a pharmaceutically acceptable salt thereof; wherein -----, R1, R2, R5, A and L are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use and treatment, e.g., such for inducing sedation and/or anesthesia.

公开(公告)号：US11498940B2

公开(公告)日：2022-11-15

申请号：US16843822

申请日：2020-04-08

Applicant: Sage Therapeutics, Inc.

Inventor： Gabriel Martinez Botella ,  Boyd L. Harrison ,  Albert Jean Robichaud ,  Francesco G. Salituro ,  Robert Jason Herr ,  Robert Borbo Kargbo

IPC: C07J43/00 ,  A61K31/58 ,  C07J7/00 ,  A61K45/06 ,  C07J21/00 ,  C07J1/00 ,  C07J13/00

Abstract: Described herein are neuroactive steroids of the Formula (I): or a pharmaceutically acceptable salt thereof; wherein -------, R1, R2, R5, A and L are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use and treatment, e.g., such for inducing sedation and/or anesthesia.

公开(公告)号：US20160229887A1

公开(公告)日：2016-08-11

申请号：US14913920

申请日：2014-08-22

Applicant: SAGE THERAPEUTICS, INC.

Inventor： Gabriel Martinez Botella ,  Boyd L. Harrison ,  Albert Jean Robichaud ,  Francesco Gerald Salituro ,  Robert Jason Herr ,  Robert Borbo Kargbo

IPC: C07J43/00

CPC classification number: C07J43/003 ,  A61K31/58 ,  A61K45/06 ,  C07J1/0059 ,  C07J7/002 ,  C07J7/007 ,  C07J7/0085 ,  C07J13/007 ,  C07J21/00 ,  C07J21/008 ,  A61K2300/00

Abstract: Described herein are neuroactive steroids of the Formula (I): or a pharmaceutically acceptable salt thereof; wherein -------, R1, R2, R5, A and L are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use and treatment, e.g., such for inducing sedation and/or anesthesia.

Abstract translation: 本文描述了式（I）的神经活性类固醇或其药学上可接受的盐; 其中 - ， - ，R1，R2，R5，A和L如本文所定义。 在某些实施方案中，可以想到这样的化合物表现为GABA调节剂。 本发明还提供包含本发明化合物和使用和治疗方法的药物组合物，例如用于诱导镇静和/或麻醉。