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公开(公告)号：US12105079B2
公开(公告)日：2024-10-01
申请号：US17269771
申请日：2019-09-11
发明人： Gang Huang , Giovanni Maglia
IPC分类号： G01N33/487 , C07K14/435 , G01N27/447
CPC分类号： G01N33/48721 , C07K14/43595 , G01N27/44791 , C07K2319/03 , C07K2319/21 , C07K2319/22
摘要： The invention relates to the field of nanopores, in particular to engineered Fragaceatoxin C (FraC) nanopores and their application in analyzing biopolymers and other (biological) compounds, such as single-molecule (protein) sequencing. Provided is a system comprising oligomeric FraC nanopores comprised in a lipid bilayer, wherein the sum of the nanopore fraction in the heptameric (Type II) state and the nanopore fraction in the hexameric (Type III) state represents at least 60% of the total number of FraC nanopores.
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公开(公告)号：US20230176034A1
公开(公告)日：2023-06-08
申请号：US17905911
申请日：2021-03-11
发明人： Giovanni Maglia , Gang Huang , Mikhael Soskine
IPC分类号： G01N33/487
CPC分类号： G01N33/48721 , B82Y40/00
摘要： The invention relates generally to the field of nanopores and the use thereof in analyzing biopolymers. In particular, it relates to engineered biological nanopores and their application in single molecule analysis, such as single molecule protein identification.
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公开(公告)号：US20190292235A1
公开(公告)日：2019-09-26
申请号：US16317119
申请日：2017-05-24
IPC分类号： C07K14/435 , G01N33/487 , C12Q1/6869 , G01N27/447
摘要： The invention relates generally to the field of nanopores and the use thereof in various applications, such as analysis of biopolymers and macromolecules, typically by making electrical measurements during translocation through a nanopores. Provided is a system comprising a funnel-shaped proteinaceous nanopore comprising an a-helical pore-forming toxin that is a member from the actinoporin protein family, more in particular Fragaceatoxin C (FraC), a mutant FraC, a FraC paralog, or a FraC homolog.
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公开(公告)号：US20220242922A1
公开(公告)日：2022-08-04
申请号：US17696949
申请日：2022-03-17
IPC分类号： C07K14/435 , C12Q1/6869 , G01N27/447 , G01N33/487
摘要： The invention relates generally to the field of nanopores and the use thereof in various applications, such as analysis of biopolymers and macromolecules, typically by making electrical measurements during translocation through a nanopores. Provided is a system comprising a funnel-shaped proteinaceous nanopore comprising an α-helical pore-forming toxin that is a member from the actinoporin protein family, more in particular Fragaceatoxin C (FraC), a mutant FraC, a FraC paralog, or a FraC homolog.
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公开(公告)号：US11312755B2
公开(公告)日：2022-04-26
申请号：US16317119
申请日：2017-05-24
IPC分类号： G01N27/26 , C07K14/435 , C12Q1/6869 , G01N27/447 , G01N33/487 , G01N33/48 , C12Q1/68 , B82Y5/00
摘要： The invention relates generally to the field of nanopores and the use thereof in various applications, such as analysis of biopolymers and macromolecules, typically by making electrical measurements during translocation through a nanopores. Provided is a system comprising a funnel-shaped proteinaceous nanopore comprising an a-helical pore-forming toxin that is a member from the actinoporin protein family, more in particular Fragaceatoxin C (FraC), a mutant FraC, a FraC paralog, or a FraC homolog.
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