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公开(公告)号：US20230032607A1
公开(公告)日：2023-02-02
申请号：US17863349
申请日：2022-07-12
Applicant: Regeneron Pharmaceuticals, Inc.
Inventor： Yu Feng , Shunhai Wang
IPC: G01N33/68
Abstract: The present invention generally pertains to methods of determining the amino acid sequence of a protein. In particular, the present invention pertains to the use of position-selective dimethylation and liquid chromatography-mass spectrometry to enhance the signal of N-terminal peptides and shift the signal of N-terminal peptides and corresponding b ions, thus facilitating a determination of the sequence of N-terminal peptides.
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