公开(公告)号：US08478420B2

公开(公告)日：2013-07-02

申请号：US11457033

申请日：2006-07-12

Applicant: Randolph K. Armstrong ,  Scott A. Armstrong

Inventor： Randolph K. Armstrong ,  Scott A. Armstrong

IPC: A61N1/08

CPC classification number: A61N1/08 ,  A61N1/36142 ,  A61N1/36153 ,  A61N1/3704

Abstract: A method is provided including delivering at least one electrical signal to tissue of a patient through an electrode. The method further includes assessing whether a net charge remains on the electrode a predetermined period of time after the delivery of the electrical signal. Systems for delivering such a signal, and assessing whether a net charge remains on the electrode providing the signal, are also provided.

Abstract translation: 提供了一种方法，包括通过电极将至少一个电信号递送给患者的组织。 该方法还包括评估在电信号传递之后预定时间段内电极是否保留在电极上。 还提供了用于传送这种信号的系统，以及评估净电荷是否保留在提供信号的电极上。

公开(公告)号：US08437853B2

公开(公告)日：2013-05-07

申请号：US13359720

申请日：2012-01-27

Applicant: Dana Michael Inman ,  Randolph K. Armstrong ,  Scott A. Armstrong

Inventor： Dana Michael Inman ,  Randolph K. Armstrong ,  Scott A. Armstrong

IPC: A61N1/36

CPC classification number: A61N1/36082 ,  A61N1/36114 ,  A61N1/36142 ,  A61N1/36146 ,  A61N1/3718

Abstract: An implantable medical device (IMD) may include a lead circuit including a first node configured to be coupled to a first lead that may be coupled to a first target tissue and including a second node configured to be coupled to a second lead that may be coupled to a second target tissue. The IMD may include an impedance unit that may determine at least one characteristic of coupled energy associated with the lead circuit, where the coupled energy may be produced by a source external to the IMD. The impedance unit may provide an impedance between the first node and the second node, where the impedance is selected based at least in part on a characteristic of the coupled energy. The impedance is selected to reduce the coupled energy or a negative effect associated with functionality of the IMD induced by the coupled energy.

Abstract translation: 可植入医疗装置（IMD）可以包括引线电路，其包括被配置为耦合到第一引线的第一节点，第一引线可以耦合到第一目标组织，并且包括被配置为耦合到第二引线的第二节点， 到第二靶组织。 IMD可以包括阻抗单元，其可以确定与引线电路相关联的耦合能量的至少一个特性，其中耦合能量可以由IMD外部的源产生。 阻抗单元可以在第一节点和第二节点之间提供阻抗，其中至少部分地基于耦合能量的特性来选择阻抗。 选择阻抗以减少耦合能量或与由耦合能量引起的IMD的功能相关联的负面影响。

公开(公告)号：US08560070B2

公开(公告)日：2013-10-15

申请号：US12725962

申请日：2010-03-17

Applicant: Randolph K. Armstrong ,  Scott A. Armstrong ,  D. Michael Inman ,  Timothy L. Scott

Inventor： Randolph K. Armstrong ,  Scott A. Armstrong ,  D. Michael Inman ,  Timothy L. Scott

IPC: A61N1/00

CPC classification number: A61N1/08 ,  A61N1/3708 ,  A61N1/378

Abstract: A method and an apparatus for determining a time period remaining in a useful life of an energy storage device in an implantable medical device. The method may include measuring a voltage of the energy storage device to produce a measured voltage, and comparing the measured voltage to a transition voltage. While the measured voltage is greater than or equal to the transition voltage, the time period remaining in the energy storage device's useful life is approximated based upon a function of charge depleted. While the measured voltage is less than the transition voltage, the time period remaining in the energy storage device's useful life is approximated based upon a higher order polynomial function of the measured voltage. The transition voltage corresponds to a predetermined point on a energy storage device voltage depletion curve representing the voltage across the energy storage device over time.

Abstract translation: 一种用于确定可植入医疗装置中的能量存储装置的使用寿命中剩余的时间段的方法和装置。 该方法可以包括测量能量存储装置的电压以产生测量的电压，并将测量的电压与转换电压进行比较。 当测量的电压大于或等于转换电压时，能量存储器件的使用寿命中剩余的时间段基于电荷耗尽的函数近似。 当测量的电压小于转换电压时，能量存储器件的使用寿命中剩余的时间段基于所测量的电压的较高阶多项式函数近似。 转换电压对应于表示能量存储装置上的电压随时间的电压耗尽曲线上的预定点。

公开(公告)号：US07974688B2

公开(公告)日：2011-07-05

申请号：US12189743

申请日：2008-08-11

Applicant: Randolph K. Armstrong ,  Scott A. Armstrong

Inventor： Randolph K. Armstrong ,  Scott A. Armstrong

IPC: A61N1/08

CPC classification number: A61N1/36135 ,  A61N1/37211

Abstract: A method sensing at least two physiological parameters and, for each of the at least two physiological parameters, generating a first series of signals representative of the physiological parameter sensed over a first time period, storing each of said first series of signals as a time sequence data stream, and determining when a physiological event has occurred in a patient. The method further comprises analyzing each of said time sequence data streams for a predetermined time interval preceding the occurrence of a physiological event to determine at least one marker as a predictor of the event, and again sensing the physiological parameters. Furthermore, the method comprises generating a second series of signals representative of the physiological parameter sensed, analyzing each of the second series of signals to determine whether the marker is present, and stimulating a cranial nerve when the marker is present in the second series of signals.

Abstract translation: 一种感测至少两个生理参数的方法，并且对于所述至少两个生理参数中的每一个，产生表示在第一时间段内感测的生理参数的第一序列信号，将所述第一系列信号中的每一个存储为时间序列 数据流，以及确定患者何时发生生理事件。 该方法还包括在生理事件发生之前的预定时间间隔内分析每个所述时间序列数据流，以将至少一个标记确定为事件的预测因子，并再次感测生理参数。 此外，该方法包括产生代表感测的生理参数的第二系列信号，分析第二系列信号中的每一个以确定标记是否存在，以及当标记存在于第二系列信号中时刺激颅神经 。

公开(公告)号：US20070179548A1

公开(公告)日：2007-08-02

申请号：US11588798

申请日：2006-10-27

Applicant: Randolph K. Armstrong ,  Scott A. Armstrong ,  D. Michael Inman ,  Timothy L. Scott

Inventor： Randolph K. Armstrong ,  Scott A. Armstrong ,  D. Michael Inman ,  Timothy L. Scott

IPC: A61N1/00

CPC classification number: A61N1/08 ,  A61N1/3708 ,  A61N1/378

Abstract: A method and an apparatus for determining a time period remaining in a useful life of an energy storage device in an implantable medical device. The method may include measuring a voltage of the energy storage device to produce a measured voltage, and comparing the measured voltage to a transition voltage. While the measured voltage is greater than or equal to the transition voltage, the time period remaining in the energy storage device's useful life is approximated based upon a function of charge depleted. While the measured voltage is less than the transition voltage, the time period remaining in the energy storage device's useful life is approximated based upon a higher order polynomial function of the measured voltage. The transition voltage corresponds to a predetermined point on a energy storage device voltage depletion curve representing the voltage across the energy storage device over time.

Abstract translation: 一种用于确定可植入医疗装置中的能量存储装置的使用寿命中剩余的时间段的方法和装置。 该方法可以包括测量能量存储装置的电压以产生测量的电压，并将测量的电压与转换电压进行比较。 当测量的电压大于或等于转换电压时，能量存储器件的使用寿命中剩余的时间段基于电荷耗尽的函数近似。 当测量的电压小于转换电压时，能量存储器件的使用寿命中剩余的时间段基于所测量的电压的较高阶多项式函数近似。 转换电压对应于表示能量存储装置上的电压随时间的电压耗尽曲线上的预定点。

公开(公告)号：US08600521B2

公开(公告)日：2013-12-03

申请号：US11045602

申请日：2005-01-27

Applicant: Randolph K. Armstrong ,  Scott A. Armstrong

Inventor： Randolph K. Armstrong ,  Scott A. Armstrong

IPC: A61N1/36

CPC classification number: A61N1/36139 ,  A61B5/05 ,  A61B5/4094 ,  A61N1/36071 ,  A61N1/36082 ,  A61N1/36114

Abstract: In one embodiment, an implantable neurostimulator comprises a pulse generator that generates an electrical pulse signal to stimulate a neural structure in a patient, a stimulation lead assembly coupled to the pulse generator for delivering the electrical pulse signal to the neural structure, a plurality of sensors coupled to the pulse generator, and sensor select logic. Each sensor is individually selectable and the sensor select logic selects any two or more of the plurality of sensors for sensing a voltage difference between the selected sensors. In other embodiments, two or more physiologic parameters are sensed. In yet another embodiment, a method comprises sensing intrinsic electrical activity on a person's nerve and stimulating the nerve based on the sensed intrinsic electrical activity of the nerve.

Abstract translation: 在一个实施例中，可植入神经刺激器包括产生电脉冲信号以刺激患者中的神经结构的脉冲发生器，耦合到脉冲发生器的刺激引线组件，用于将电脉冲信号传递到神经结构，多个传感器 耦合到脉冲发生器和传感器选择逻辑。 每个传感器可单独选择，传感器选择逻辑选择多个传感器中的任何两个或多个传感器，用于感测所选传感器之间的电压差。 在其他实施例中，感测到两个或更多生理参数。 在另一个实施例中，一种方法包括基于感测到的神经内在电活动来感测人的神经上的固有电活动并刺激神经。

公开(公告)号：US08565881B2

公开(公告)日：2013-10-22

申请号：US12820841

申请日：2010-06-22

Applicant: Randolph K. Armstrong ,  Scott A. Armstrong ,  D. Michael Inman ,  Timothy L. Scott

Inventor： Randolph K. Armstrong ,  Scott A. Armstrong ,  D. Michael Inman ,  Timothy L. Scott

IPC: A61N1/00

CPC classification number: A61N1/08 ,  A61N1/3708 ,  A61N1/378

Abstract: A method and an apparatus for projecting an end of service (EOS) and/or an elective replacement indication (ERI) of a component in an implantable device is provided. The method comprises measuring the measured voltage of the energy storage device, and determining whether the measured voltage is less than a transition voltage. When the measured voltage is less than the transition voltage, determining a time period remaining until an end of service of the energy storage device is based upon a function of the measured voltage. When the measured voltage is greater than or equal to the transition voltage, determining a time period remaining until an end of service of the energy storage device is based upon a function of the total charge depleted. The transition voltage is a voltage associated with the transition point of non-linearity in the battery voltage depletion curve.

Abstract translation: 提供了一种用于在可植入装置中投射组件的服务结束（EOS）和/或选择性替换指示（ERI）的方法和装置。 该方法包括测量能量存储装置的测量电压，以及确定测得的电压是否小于转换电压。 当测量的电压小于转换电压时，确定剩余的能量储存装置的使用时间是基于所测量的电压的函数。 当测量的电压大于或等于转换电压时，确定能量存储装置的使用结束之前剩余的时间是基于耗尽的总电荷的函数。 转换电压是与电池电压耗尽曲线中的非线性转变点相关的电压。

公开(公告)号：US07489561B2

公开(公告)日：2009-02-10

申请号：US11257267

申请日：2005-10-24

Applicant: Randolph K. Armstrong ,  Scott A. Armstrong

Inventor： Randolph K. Armstrong ,  Scott A. Armstrong

IPC: G11C11/34

CPC classification number: A61N1/37264

Abstract: A device comprises a stimulus generator comprising an instruction processor. The stimulus generator is configured to deliver stimuli to a biological tissue. The device also comprises a non-volatile memory for storing instructions directly executable by the instruction processor, the instructions controlling, at least in part, the operation of the device. The instruction processor generates an erase control signal to erase at least a segment of the non-volatile memory and a write control signal to write one or more new instructions to at least a segment of the non-volatile memory, thereby modifying the operation of the device.

Abstract translation: 一种装置包括一个包括指令处理器的刺激发生器。 刺激发生器被配置为将刺激递送到生物组织。 该设备还包括用于存储可由指令处理器直接执行的指令的非易失性存储器，该指令至少部分地控制该设备的操作。 指令处理器产生擦除控制信号以擦除非易失性存储器的至少一个段和写入控制信号，以将一个或多个新指令写入非易失性存储器的至少一个段，由此修改 设备。

公开(公告)号：US20080103532A1

公开(公告)日：2008-05-01

申请号：US11588512

申请日：2006-10-27

Applicant: Scott A. Armstrong ,  Randolph K. Armstrong

Inventor： Scott A. Armstrong ,  Randolph K. Armstrong

IPC: A61N1/36

CPC classification number: A61N1/3605 ,  A61N1/36064 ,  A61N1/36082

Abstract: In some embodiments, a method comprises providing an electrical signal to a nerve to evoke an action potential. The nerve thereby enters a refractory period in which the nerve is in a refractory state. The method further comprises, during the refractory period, providing an electrical signal to the nerve thereby altering the refractory period of the nerve or non-target tissues.

Abstract translation: 在一些实施例中，一种方法包括向神经提供电信号以引起动作电位。 因此神经进入神经处于难治状态的难治期。 该方法还包括在不应期内，向神经提供电信号，从而改变神经或非靶组织的不应期。

公开(公告)号：US20070016263A1

公开(公告)日：2007-01-18

申请号：US11180745

申请日：2005-07-13

Applicant: Randolph K. Armstrong ,  Scott A. Armstrong

Inventor： Randolph K. Armstrong ,  Scott A. Armstrong

IPC: A61N1/00

CPC classification number: A61N1/0551 ,  A61N1/36082 ,  A61N1/36114 ,  A61N1/375

Abstract: A method, system, and an apparatus for providing a therapy neurostimulation signal. The apparatus of the present invention includes a sealed housing being of a total volume of less than about 14.5 cc and a power supply contained within the sealed housing. The power supply includes a charge capacity of at least about 100 milliAmpHours. The apparatus also includes a controller to control an operation of the power supply and to provide an electrical neurostimulation signal for stimulating a portion of a neural tissue. The present invention also provides for implementing an interrupt-driven architecture into an implantable medical device.

Abstract translation: 一种用于提供治疗神经刺激信号的方法，系统和装置。 本发明的装置包括总体积小于约14.5cc的密封壳体和包含在密封壳体内的电源。 电源包括至少约100毫安小时的充电容量。 该装置还包括控制器，用于控制电源的操作并提供用于刺激神经组织的一部分的电神经刺激信号。 本发明还提供了将中断驱动架构实现到可植入医疗装置中。