公开(公告)号：US3873510A

公开(公告)日：1975-03-25

申请号：US38854673

申请日：1973-08-15

Applicant: RICHTER GEDEON VEGYESZET

Inventor： KISFALUDY LAJOS ,  LOW MIKLOS ,  DANCSI LAJOS ,  SCHON ISTVAN ,  SZIRTES TAMAS ,  NYEKI OLGA ,  SZIRMAI MARIA ,  SZPORNY LASZLO ,  HAJOS GYORGY

IPC: C07K14/575 ,  A61K38/00 ,  A61K38/22 ,  C07K1/06 ,  C07K14/695 ,  C07C103/52 ,  A61K17/06

CPC classification number: C07K14/6955 ,  A61K38/00 ,  C07K14/695 ,  Y10S514/805

Abstract: Novel peptides of ACTH activity, having a complete ACTH sequence from the N-terminal amino acid at least to the sixteenth amino acid, but containing optionally other amino acids in the place of the individual amino acids of the ACTH sequence, and always containing an Alpha -aminooxy acid in the place of the first amino acid have been prepared by deblocking the appropriate protected peptide derivatives. The new compounds, as well as their acid addition salts, derivatives or complexes possess potent ACTH activities and are resistant to enzymatic decomposition. They can be used in therapy with great advantages.

Abstract translation: 具有ACTH活性的新肽，具有至少至第十六氨基酸的N-末端氨基酸的完整ACTH序列，但含有任选的其它氨基酸代替ACTH序列的各个氨基酸，并且总是含有α - 氨基氧酸代替第一个氨基酸已经通过解封合适当的保护肽衍生物来制备。

公开(公告)号：US3862111A

公开(公告)日：1975-01-21

申请号：US38854773

申请日：1973-08-15

Applicant: RICHTER GEDEON VEGYESZET

Inventor： LOW MIKLOS ,  KISFALUDY LAJOS ,  PATTHY AGNES ,  SZIRMAI MARIA ,  NYEKI OLGA ,  SZPORNY LASZLO ,  HAJOS GYORGY

IPC: C07K14/575 ,  A61K38/00 ,  A61K38/10 ,  A61K38/22 ,  A61P5/00 ,  C07K7/08 ,  C07K14/695 ,  C07C103/52 ,  A61K17/06

CPC classification number: C07K14/695 ,  A61K38/00 ,  Y10S514/805

Abstract: Novel peptides of ACTH activities having a complete ACTH sequence from the N-terminal amino acid at least to the 17th but at most to the 19th amino acid, but containing optionally other amino acids in the place of the individual amino acids of the ACTH sequence, and always containing an Alpha -aminooxy acid in the place of the first and the last amino acids have been prepared by deblocking the appropriate protected peptide derivatives. The new compounds, as well as their acid addition salts, derivatives or complexes possess potent ACTH activities and can be used in the therapy with great advantages.

Abstract translation: 具有AC末端氨基酸至少至第17个至第19个氨基酸但含有任意其它氨基酸代替ACTH序列的各个氨基酸的完整ACTH序列的新型ACTH活性肽， 并且总是含有代替第一和最后一个氨基酸的α-氨基氧酸已经通过解封合适的保护的肽衍生物来制备。