公开(公告)号：US3873510A

公开(公告)日：1975-03-25

申请号：US38854673

申请日：1973-08-15

Applicant: RICHTER GEDEON VEGYESZET

Inventor： KISFALUDY LAJOS ,  LOW MIKLOS ,  DANCSI LAJOS ,  SCHON ISTVAN ,  SZIRTES TAMAS ,  NYEKI OLGA ,  SZIRMAI MARIA ,  SZPORNY LASZLO ,  HAJOS GYORGY

IPC: C07K14/575 ,  A61K38/00 ,  A61K38/22 ,  C07K1/06 ,  C07K14/695 ,  C07C103/52 ,  A61K17/06

CPC classification number: C07K14/6955 ,  A61K38/00 ,  C07K14/695 ,  Y10S514/805

Abstract: Novel peptides of ACTH activity, having a complete ACTH sequence from the N-terminal amino acid at least to the sixteenth amino acid, but containing optionally other amino acids in the place of the individual amino acids of the ACTH sequence, and always containing an Alpha -aminooxy acid in the place of the first amino acid have been prepared by deblocking the appropriate protected peptide derivatives. The new compounds, as well as their acid addition salts, derivatives or complexes possess potent ACTH activities and are resistant to enzymatic decomposition. They can be used in therapy with great advantages.

Abstract translation: 具有ACTH活性的新肽，具有至少至第十六氨基酸的N-末端氨基酸的完整ACTH序列，但含有任选的其它氨基酸代替ACTH序列的各个氨基酸，并且总是含有α - 氨基氧酸代替第一个氨基酸已经通过解封合适当的保护肽衍生物来制备。

公开(公告)号：US3642805A

公开(公告)日：1972-02-15

申请号：US3642805D

申请日：1969-03-26

Applicant: RICHTER GEDEON VEGYESZET

Inventor： KISFALUDY LAJOS ,  DANCSI LAJOS ,  KARPATI EGON ,  SZPORNY LASZLO

IPC: A61K31/16 ,  A61K31/165 ,  A61P9/12 ,  A61P25/04 ,  A61P25/20 ,  C07C67/00 ,  C07C231/00 ,  C07C239/00 ,  C07C259/06 ,  C07D207/16 ,  C07D213/78 ,  C07K5/06 ,  C07D31/36

CPC classification number: C07D213/78 ,  C07D207/16 ,  C07K5/06026 ,  Y02P20/55

Abstract: NEW N-ACYLATED HYDROXYLAMINE DERIVATIVES OF THE FORMULA

AC-NH-O-X

WHEREIN AC IS AN ACYL GROUP OF A CARBOXYLIC ACID CONTAINING ONE OR MORE BASIC NITROGEN ATOMS WITH THE EXCEPTION OF THE ALIPHATIC AMINO ACIDS LEUCINE, VALINE AND ALANINE AND X IS AN ARALKYL GROUP UNSUBSTITUTED OR SUBSTITUTED BY HALOGEN, LOWER ALKYL, LOWER ALKOXY OR THE NITRO GROUP, AND THE PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF, HAVING HYPOTENSIVE AND SEDATIVE EFFECT. THE NEW COMPOUNDS ARE PREPARED BY N-ACYLATIG AN /-SUBSTITUTED HYDROXYLAMINE OF THE FORMULA H2N-OX WITH THE CORRESPONDING AMINO ACID OR A REACTIVE DERIVATIVE THEREOF OR BY O-ARALKYLATING N- ACYLATED HYDROXYLAMINES

AC-NH-OH

WITH AN ARALKYL HALIDE HAL-X.