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1.发明公开公开(公告)号：US20230201360A1
公开(公告)日：2023-06-29
申请号：US18077484
申请日：2022-12-08
发明人： Jae Hyung PARK , Wooram UM , Hyeyeon JOO
IPC分类号： A61K47/54 , A61K35/745 , A61K35/747 , A61P1/14
CPC分类号： A61K47/555 , A61K35/745 , A61K35/747 , A61P1/14
摘要： The present disclosure relates to a composition and a kit for colonization of external probiotics in the gut through bioorthogonal click chemistry. The composition or kit for colonization of external probiotics in the gut according to the present disclosure has the effects of overcoming colonization resistance, which is the limitation of existing external probiotics caused by physical discharge and indigenous bacteria, by linking surface-modified external probiotics to the intestinal mucosa into which a bioorthogonal functional group has been introduced, and beneficially changing the intestinal environment by long-term colonization of various external probiotics, such as lactic acid bacteria, bifidobacteria, and yeast. Accordingly, the present disclosure is expected to be effectively used for the development of various medicines and functional foods using probiotics.
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公开(公告)号：US20220370609A1
公开(公告)日：2022-11-24
申请号：US17748197
申请日：2022-05-19
发明人： Jae Hyung PARK , Jueun JEON , Been YOON
摘要： The present invention relates to a polymer composite for ultrasound-based cancer immunotherapy, which comprises an peroxalate derivatives, and a preparation method thereof. The polymer composite according to the present invention is a structure in which the peroxalate derivatives are encapsulated in an amphipathic polymer compound in which a biocompatible polymer and a sonosensitizer are combined. The peroxalate derivatives produce free electrons and carbon dioxide (CO2) by reaction with a high concentration of hydrogen peroxide (H2O2) in cancer tissue, the generated electrons raise the energy level of the sonosensitizer in the polymer composite to increase the amount of reactive oxygen species (ROS) production, thereby exhibiting an effect of increasing the death rate of cancer cells. In addition, by ultrasound treatment, immunogenic cell death (ICD) is induced due to the cavitation effect of the produced CO2, so molecules capable of activating immune cells in cancer cells are released without damage to induce an immune response to cancer. Therefore, the polymer composite according to the present invention is expected to be effectively used as an ultrasound-based cancer immunotherapeutic agent.
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公开(公告)号：US20230241119A1
公开(公告)日：2023-08-03
申请号：US18105355
申请日：2023-02-03
发明人： Jae Hyung PARK , Dong Gyu JO , Sol SHIN , Jae Hoon SUL
IPC分类号： A61K35/30 , A61K31/137 , A61P25/28
CPC分类号： A61K35/30 , A61K31/137 , A61P25/28
摘要： The present disclosure relates to a pharmaceutical composition for preventing or treating a brain disease, comprising a stem cell-derived exosome surface-modified with a compound capable of binding to dopamine receptors or L-amino acid transporters as an active ingredient. The stem cell-derived exosome according to the present disclosure selectively binds to dopamine receptors (D2) overexpressed as autoreceptors in dopaminergic neurons in the substantia nigra through surface modification. Thereby, local accumulation in dopaminergic neurons is possible. In addition, it was identified that the stem cell-derived exosome exhibited an excellent neuron protective effect and neuron death inhibitory effect. Accordingly, the surface-modified stem cell-derived exosome according to the present disclosure is expected to be usefully used as a composition for preventing or treating a brain disease including Parkinson's disease and Alzheimer's disease.
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公开(公告)号：US20220079998A1
公开(公告)日：2022-03-17
申请号：US17474118
申请日：2021-09-14
发明人： Jae Hyung PARK , Dong Gil YOU , Gyeong Taek LIM , Jae Min JUNG , Byeong Hoon OH
IPC分类号： A61K35/545 , A61K35/28 , A61K35/51 , A61K35/50 , A61K35/32 , A61K47/69 , A61K47/54 , A61K9/127 , A61P19/02
摘要： The present invention relates to a composition for preventing, improving and treating an inflammatory macrophage-mediated autoimmune disease, including a stem cell-derived exosome surface-modified with a sugar compound to target an activated macrophage, and the composition according to the present invention may specifically target an activated macrophage to increase the therapeutic efficiency for various types of autoimmune diseases including rheumatoid arthritis. In addition, the composition according to the present invention has a more excellent therapeutic effect and minimizes side effects compared with conventional antiinflammatory agents, stem cell therapeutic agents or exosomes because it contains a gene, protein or growth factor related to the proliferation, differentiation and regeneration of stem cells, and does not include an antibiotic or serum, or harmful factors of the cell culture.
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5.发明申请SONOSENSITIZER COMPOSITION CONTAINING TITANIUM OXIDE NANOPARTICLE AS ACTIVE INGREDIENT, COMPOSITION FOR PREVENTING OR TREATING CANCER COMPRISING THE SAME, AND THE PREPARATION THEREOF 审中-公开作为活性成分的含有氧化钛纳米粒子的SONOSENSITIZER组合物，用于预防或治疗包含其的癌症的组合物及其制备方法公开(公告)号：US20170007699A1
公开(公告)日：2017-01-12
申请号：US14797435
申请日：2015-07-13
CPC分类号： A61K41/0033 , A61K9/5161 , A61K9/5192 , A61K33/24 , A61K47/6939 , A61N7/00 , A61N2007/0004
摘要： The present invention relates to a sonosensitizer composition containing titanium dioxide nanoparticles as an active ingredient, a composition for preventing or treating cancer containing the same, and a method of preparing the same. The sonosensitizer of the present invention can solve the problem of the conventional photosensitizer, which can be used only when light can reach the target area, and increase the accumulation level of the sonosensitizer of the present invention to a maximum level within a short time, thereby enabling reduction of the time required for treatment and, due to its human-friendly stability, effective use in cancer treatment.
摘要翻译： 本发明涉及包含二氧化钛纳米颗粒作为活性成分的预敏化剂组合物，含有该二氧化钛纳米颗粒的活性成分的预防或治疗癌症的组合物及其制备方法。 本发明的超声增敏剂可以解决传统的光敏剂的问题，只有当光可以到达目标区域时才能使用，并且可以在短时间内将本发明的超声波增敏剂的积聚水平提高到最高水平， 能够减少治疗所需的时间，并且由于其人性化的稳定性，有效地用于癌症治疗。
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公开(公告)号：US20240117052A1
公开(公告)日：2024-04-11
申请号：US18376920
申请日：2023-10-05
发明人： Jae Hyung PARK , Seok Ho SONG , Torsha GHOSH
CPC分类号： C07K16/2818 , A61K47/10 , A61P35/00
摘要： Disclosed is an antibody for cancer treatment conjugated with a tumor environment-sensitive cleavable polyethylene glycol, wherein the use of the antibody for cancer treatment can suppress side effects of the antibody while maintaining therapeutic effects thereof.
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公开(公告)号：US20230113262A1
公开(公告)日：2023-04-13
申请号：US17818874
申请日：2022-08-10
发明人： Jae Hyung PARK , Joshua Alexander JACKMAN , Hyewon KO , Sol SHIN , Bo Kyeong YOON , Chanho KIM , Soyoung SON
IPC分类号： A61K39/00 , C07K14/705
摘要： The present invention relates to a peptide for cancer immunotherapy that disrupts tumor-derived vesicles and a use thereof. The peptide according to the present invention has an α-helical structure, inhibits T-cell functional impairment caused by tumor-derived vesicles and controls the formation of a tumor microenvironment as an immunosuppressive environment by disrupting the tumor-derived vesicles, and has effects of not only enhancing cancer immunotherapy activity but also inhibiting the metastasis of cancer cells through co-administration with an immune checkpoint inhibitor. Additionally, when the peptide is modified with PEG through a pH-sensitive linker, it has effects of increasing the stability of the peptide in vivo, and disrupting tumor-derived vesicles under the pH condition of the tumor microenvironment. Accordingly, the peptide of the present invention is expected to be effectively used in a composition for cancer immunotherapy, a composition for enhancing the sensitivity of cancer immunotherapy, or the composition for inhibiting cancer metastasis.
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