公开(公告)号：US09670199B2

公开(公告)日：2017-06-06

申请号：US14443576

申请日：2013-11-19

申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA

发明人： Peter Dosa ,  Suck Won Kim ,  Michael Walters

IPC分类号： A61K31/48 ,  C07D457/06 ,  C07D457/02 ,  C07D457/04

CPC分类号： C07D457/06 ,  C07D457/02 ,  C07D457/04

摘要： The invention provides compounds of formula I: wherein R1-R4 have any of the values defined in the specification, and salts thereof. The compounds are useful as dopamine receptor modulators for the treatment of diseases where modulation of dopamine receptors is implicated (e.g. sexual dysfunction, prolactinoma, Parkinson's disease, and Cushings disease).

公开(公告)号：US20150307486A1

公开(公告)日：2015-10-29

申请号：US14443576

申请日：2013-11-19

申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA

发明人： Peter Dosa ,  Suck Won Kim ,  Michael Walters

IPC分类号： C07D457/06 ,  C07D457/02 ,  C07D457/04

CPC分类号： C07D457/06 ,  C07D457/02 ,  C07D457/04

摘要： The invention provides compounds of formula (I) wherein R1-R4 have any of the values defined in the specification, and salts thereof. The compounds are useful as dopamine receptor modulators for the treatment of diseases where modulation of dopamine receptors is implicated (e.g. sexual dysfunction, prolactinoma, Parkinson's disease, and Cushings disease).

摘要翻译： 本发明提供式（I）化合物，其中R 1 -R 4具有说明书中定义的任何值及其盐。 该化合物可用作多巴胺受体调节剂，用于治疗涉及多巴胺受体调节的疾病（例如性功能障碍，催乳素瘤，帕金森病和缓冲疾病）。