-
公开(公告)号:US20200215052A1
公开(公告)日:2020-07-09
申请号:US16625011
申请日:2018-06-29
申请人: PURDUE PHARMA L.P.
发明人: Alessandra CIPRIANO , Salvatore COLUCCI , Stephen HARRIS , Michelle HUMMEL , Donald KYLE , Garth WHITESIDE
IPC分类号: A61K31/485 , A61K31/4468 , A61K9/00
摘要: The invention provides an oral dosage form comprising (i) an amount of oxycodone and (ii) an amount of buprenorphine, wherein the weight ratio of the amount of buprenorphine to the amount of oxycodone is greater than 1:40 calculated with the amount of buprenorphine in the dosage form expressed as the equimolar amount of buprenorphine base (Mw=467.64 g/mol) in mg, and the amount of oxycodone in the dosage form expressed as the equimolar amount of oxycodone hydrochloride (Mw=351.82 g/mol) in mg. The invention also provides combinations of an opioid agonist and buprenorphine for use to treat pain, wherein the combination achieves a reduction of adverse pharmacodynamic responses (such as, respiratory depression), compared with a corresponding stand-alone opioid therapy. The invention also includes methods of treatment and dosage forms thereof comprising such combinations.
-
公开(公告)号:US20240269133A1
公开(公告)日:2024-08-15
申请号:US18561405
申请日:2022-05-20
申请人: Purdue Pharma L.P.
发明人: Garth WHITESIDE , Stephen HARRIS
IPC分类号: A61K31/498 , A61K31/137 , A61K31/216 , A61K31/4025 , A61K31/46 , A61K31/4725 , A61P13/10
CPC分类号: A61K31/498 , A61K31/137 , A61K31/216 , A61K31/4025 , A61K31/46 , A61K31/4725 , A61P13/10
摘要: The disclosure provides a method of treating interstitial cystitis/bladder pain syndrome in a human subject in need of such treatment, comprising administering to the human subject a therapeutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof. In certain embodiments, the method comprises administering the compound of formula (IA).
-